Navigation Links
Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
Date:1/15/2012

NEW BRUNSWICK, N.J. Rutgers University and Massachusetts General Hospital (MGH) investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety.

In a report receiving advance online publication in the journal Nature Biotechnology, the team reports that inhibiting a type of cell-to-cell communication can protect against damage caused by liver-toxic drugs such as acetaminophen.

"Our findings suggest that this therapy could be a clinically viable strategy for treating patients with drug-induced liver injury," said Suraj Patel a postdoctoral researcher in the Center for Engineering in Medicine at MGH and the paper's lead author. "This work also has the potential to change the way drugs are developed and formulated, which could improve drug safety by providing medications with reduced risk of liver toxicity."

Drug-induced liver injury is the most common cause of acute liver failure in the U.S. and is also the most frequent reason for abandoning drugs early in development or withdrawing them from the market. Liver toxicity limits the development of many therapeutic compounds and presents major challenges to both clinical medicine and to the pharmaceutical industry.

Since no pharmaceutical strategies currently exist for preventing drug-induced liver injury, treatment options are limited to discontinuing the offending drug, supportive care and transplantation for end-stage liver failure.

The researchers investigated an approach that targets a liver's gap junctions hollow multimolecular channels that connect neighboring cells and allow direct communication between coupled cells. In the heart, gap junctions propagate the electrical activity required for synchronized contraction, but their role in the liver has not been well understood

Recent work has shown that gap junctions spread immune signals from injured liver cells to surrounding undama
'/>"/>

Contact: Carl Blesch
cblesch@ur.rutgers.edu
732-932-7084 x616
Rutgers University
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Even privately insured have hard time getting psychiatric care in Massachusetts: Harvard study
2. Massachusetts health-care reform increased access to care, particularly among disadvantaged
3. Massachusetts General Hospital, Iacocca Foundation announce promising results of Phase I diabetes trial
4. Study examines impact of Massachusetts health law on emergency department visits
5. Support for Massachusetts landmark health reform law rises in 2011
6. Massachusetts Study Shows Sharp Rise in Early Autism Diagnoses
7. Season of birth and celiac disease in Massachusetts children
8. Massachusetts reform hasnt stopped medical bankruptcies: Harvard study
9. Massachusetts General Hospital leading nationwide, comparative study of common bipolar medications
10. Massachusetts physician groups improving patient experience, study finds
11. Massachusetts Institute of Technology IDs new cancer drug target
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rutgers, Massachusetts General investigators find novel way to prevent drug-induced liver injury
(Date:6/19/2013)... Santiago, Chile (PRWEB) June 20, 2013 ... Chile Montaña has put together their winter season ... of outdoor adventure day trips in and around Santiago ... lead trips into Chile's Central Andes for backcountry skiing, ... , For those who have always dreamed of ...
(Date:6/19/2013)... (PRWEB) June 20, 2013 Everyone is looking for ... and inexpensive way to do so. It is called Skin ... - only 5 minutes per day - to improve health and ... improves general health. How? , Skin Brushing improves general health ... it aids the lymphatic system to drain toxins , ...
(Date:6/19/2013)... CA (PRWEB) June 19, 2013 Paleo Burn ... thousands of people finally sculpt the body they desire with ... other fat loss programs and health food products, Ken Smith ... and finally give consumers an easy, automatic, and permanent solution ... all the details . , After a quick review of ...
(Date:6/19/2013)... Brand new Hypertrophy Max bonus just released by Vince Del Monte ... Max program. Vince and Ben are only making this bonus ... must act quickly. , What is the all new Hypertrophy Max ... 12 month all access pass to the Live Large TV program ... TV is a Monday night show where over 4,000 members from ...
(Date:6/19/2013)... Shreya Rangarajan of Roland Park Country ... on the future of medicine. , Today, Brandeis ... Summit on the Future of Medicine and has selected ... the state of Maryland at the Summit. , "The ... an environment hard to imagine just a few years ...
Breaking Medicine News(10 mins):Health News:Chile Montaña Announces Winter Season Santiago Day Trips 2Health News:Chile Montaña Announces Winter Season Santiago Day Trips 3Health News:A Fast and Fun Way to Better Skin Quality and Overall Health, says Sublime Beauty® 2Health News:Paleo Burn Review Released by TotalWellnessCleanse.net 2Health News:New Hypertrophy Max Bonus Just Released and Only Available for 24 Hours 2Health News:Global Youth Summit on The Future of Medicine-Shreya Rangarajan selected to represent Roland Park Country School and The State of Maryland 2Health News:Global Youth Summit on The Future of Medicine-Shreya Rangarajan selected to represent Roland Park Country School and The State of Maryland 3
... wonder fish medicine for asthma patients began here Thursday amid ... of people were seen standing in queues for their turn ... offering by Bathini Goud family to avoid any controversy. ... cure for asthma, began at 3.42 p.m., the time fixed ...
... Intel has decided to extend its innovation beyond manufacturing ... to team up with other medical and healthcare companies’ ... and seven others have joined hands to enable high-end ... Health Alliance, led by Intel will seek to effectively ...
... longest working hours in Europe - a reason that is ... study //. ,Stress expert Cary Cooper, of Lancaster University, ... their negative effect on men's health, particularly those working in ... of the Daily Mail. ,Researchers studied 2,200 men ...
... be now treated by a new approach involving release ... with mice by scientists // at John Hopkins Institute ... Medicine. ,The discovery by researchers in Hopkins' ... Genetic Medicine reveals that a protein called GCN5 is ...
... common BP medication during first trimester of pregnancy have ... The Food and Drug Administration reports from data collected ... ,The study, led by William Cooper, M.D., M.P.H., associate ... Hospital at Vanderbilt, found infants born to mothers who ...
... Rajasthan man who has pledged not to marry till he passes ... a wife. He has failed in the examination yet again! // ... Behror town, over 140 km from here, has been taking the ... years of his life, he vowed to marry only after getting ...
Cached Medicine News:Health News:Administration of Fish Drug for Asthma Patients Begins in Andhra 2Health News:Diabetes - New Treatment Approach At John Hopkins 2Health News:Birth Defects Link With ACE Inhibitor Use, FDA Reports 2
(Date:6/19/2013)... Pharmacyclics, Inc. (the "Company") (Nasdaq: ... Journal of Medicine ( NEJM ) published results ... Bruton,s tyrosine kinase (BTK) inhibitor ibrutinib in patients with ... ibrutinib may be effective and generally well-tolerated in patients ... separate study examining the safety and efficacy of ibrutinib ...
(Date:6/19/2013)... BRAINTREE, Mass. , June 19, 2013 /PRNewswire/ ... announced several important developments in the pursuit of ... (Logo: http://photos.prnewswire.com/prnh/20120206/NE47232LOGO ) , ... SANM ) for the future production of medical ... , Massachusetts. Sanmina is a leading global provider of ...
(Date:6/19/2013)... 2013 /PRNewswire-iReach/ -- Robert M. Bernstein, M.D., ... procedures and founder of Bernstein Medical – Center ... Doctors, issue of New York Magazine for the ... ) Dr. Bernstein earned his ... reputation as world-renowned hair restoration physician, through a ...
Breaking Medicine Technology:Ibrutinib Phase 2 Study Results in Patients with Mantle Cell Lymphoma Published in The New England Journal of Medicine 2Ibrutinib Phase 2 Study Results in Patients with Mantle Cell Lymphoma Published in The New England Journal of Medicine 3Ibrutinib Phase 2 Study Results in Patients with Mantle Cell Lymphoma Published in The New England Journal of Medicine 4Ibrutinib Phase 2 Study Results in Patients with Mantle Cell Lymphoma Published in The New England Journal of Medicine 5Ibrutinib Phase 2 Study Results in Patients with Mantle Cell Lymphoma Published in The New England Journal of Medicine 6Haemonetics Announces Next Steps in Manufacturing Transformation 2Haemonetics Announces Next Steps in Manufacturing Transformation 3Haemonetics Announces Next Steps in Manufacturing Transformation 4Dr. Robert Bernstein in NY Magazine's 'Best Doctors' Issue for 14th Consecutive Year 2Dr. Robert Bernstein in NY Magazine's 'Best Doctors' Issue for 14th Consecutive Year 3
... 27 Kinex Pharmaceuticals will present results from a Phase ... Meeting in Orlando, on May 29, 2009. The study ... (RPCI) and Fox Chase Cancer Center. Dr. Alex Adjei, ... "Results of a phase I trial of KX2-391, a novel ...
... Administered in Dual Cord Blood Transplant for Hematologic MalignancyLA JOLLA, ... announced today that the first patient has been treated ... molecule Stem Cell Modulator (SCM) designed to increase hematopoietic stem ... pathways that guide cell fate. The study, which is ...
Cached Medicine Technology:Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support 2Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support 3Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support 4
Intended for the quantitative determination of magnesium in serum or plasma. Reaction: Endpoint. Wavelength: 520 nm. Linearity: 6.0 mg/dL (2.5 mmol/L)....
For the quantitative determination of Magnesium in serum. Linearity: 4.0 mEq/L. Working Reagent prepared by simple 1:10 dilution....
For the quantitative determination of total glucose in serum....
Glucose reagent is used for the quantitative determination of glucose in human serum....
Medicine Products: