Navigation Links
Rush University Medical Center scientists home in on cause of osteoarthritis pain
Date:12/27/2012

sessed development of pain-related behaviors and concomitant changes in dorsal root ganglia (DRG), nerves that carry signals from sensory organs toward the brain. They found that a chemokine known as monocyte chemoattractant protein (MCP)-1 (CCL2) and its receptor, chemokine receptor 2 (CCR2), are central to the development of pain associated with knee OA.

Monocyte chemoattractant protein-1 regulates migration and infiltration of monocytes into tissues where they replenish infection-fighting macrophages. Previous research has shown that MCP-1/CCR2 are central in pain development following nerve injury.

In the study, following surgery the laboratory mice developed mechanical allodynia that lasted 16 weeks. Levels of MCP-1, CCR2 mRNA and protein were temporarily elevated, and neuronal signaling activity increased in the DRG at eight weeks after surgery. This result correlated with the presentation of movement-provoked pain behaviors (for instance, mice with OA travelled less distance, when monitored overnight, and climbed less often on the lid of their cage suggesting that they avoid movement that triggers pain) which were maintained up to 16 weeks.

Mice that lack Ccr2 (knockout mice) also developed mechanical allodynia, but this began to resolve from eight weeks onward. Despite having severe allodynia and structural knee joint damage equal to that in normal mice, Ccr2-knockout mice did not develop movement-provoked pain behaviors at eight weeks.

To confirm the key role of CCR2 signaling in development of the observed movement-provoked pain behavior after surgery, the researchers administered a CCR2 receptor-blocker to normal mice at nine weeks after surgery and found that this reversed the decrease in distance traveled, that is, movement-provoked pain behavior.

Interestingly, levels of MCP-1 and CCR2 returned to baseline or lower by 16 weeks in mice exhibiting movement-provoked pain behaviors. This finding may suggest
'/>"/>

Contact: Nancy DiFiore
nancy_difiore@rush.edu
312-942-5159
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Case Western Reserve University receives patient-centered research award
2. The Hong Kong Polytechnic University promotes knowledge enterprises through MAKE Award
3. A Serious Problem: Medical Malpractice Lawyers at Console & Hollawell React to Alarming Doctor Error Statistics from Johns Hopkins University Researchers
4. AED.com Donates LifePak CR Plus AED to Tennessee State University Athletic Department
5. University Hospitals Neurological Institute to present 6th International 2013 Epilepsy Colloquium
6. Rice University opens new window on Parkinsons disease
7. Women’s Excellence in Bladder Control Partners with University Compounding Pharmacy in Troy, MI to Help Women with Chronic Pelvic Pain Conditions
8. Center For Sight Expands Services in University Park; David Hunt, O.D., Becomes Part of Center For Sight’s Comprehensive Eye Care Team
9. Naturecast Pets revisits New Study from University of Adelaide that may Help Dogs with Arthritis
10. University at Buffalo, The State University of New York (SUNY) Goes Live with Osprey’s Conflict of Interest COI RiskManager™
11. University of Southern Mississippi Professor Collaborates with Houston Police for Eyewitness Research Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... Sunday 31 August 2014: Mortality and morbidity ... year despite good use of oral anticoagulants, according to ... General Pilot Registry. The findings were presented for the ... chairperson Professor Gregory Lip (Birmingham, UK). , Professor Lip ... focused on management practices of European cardiologists conducted since ...
(Date:8/30/2014)... Sunday 31 August 2014: A new batteryless cardiac ... by heart motion was presented at ESC Congress ... prototype device does not require battery replacement. , ... Engineering Group at ARTORG, University of Bern, Switzerland, ... medical implants. Once they reach a critically low ...
(Date:8/30/2014)... In a world where a typical response to conflict ... launches a game app to teach another way. Launched ... app is a colorful way to encourage moral values playfully. ... pulls double-duty by teaching players new ways to find happiness ... gamers for consistently taking the high road, the Ultimate Karma ...
(Date:8/30/2014)... August 31, 2014 Atlanta based automotive ... to help raise money and awareness for ALS by ... General Managers, staff, and even Vice President Jimmy Ellis ... film and can be viewed on their Youtube page; ... the challenge, general managers and staff also took the ...
(Date:8/30/2014)... Denver, Colorado (PRWEB) August 30, 2014 The ... modeling the body that will reveal to users some shocking ... lead to great results in modeling looks, as well as ... the new method says that there is one unique trick ... new method indicates that despite what many people might think, ...
Breaking Medicine News(10 mins):Health News:AF mortality and morbidity high at 1 year despite good anticoagulant use 2Health News:Batteryless cardiac pacemaker is based on automatic wristwatch 2Health News:Newly Launched Ultimate Karma App Elicits Happiness in Players and Encourages Moral Values 2Health News:Jim Ellis Automotive Group Take the ALS Ice Bucket Challenge 2Health News:Truth about Six Pack Abs Review Reveals Unique Method to Eliminate Stubborn Stomach Fat 2
... 30 Physicians Healthcare,Management Group, Inc. (Phyhealth) (Pink Sheets: ... with physicians,today announced that its board of directors has ... of the Company,s outstanding Common Stock., The shares ... market price.,The purchases will be made at the Company,s ...
... (Logo: http://www.newscom.com/cgi-bin/prnh/20050825/CLTH069LOGO ), What: HCA ... 2008 @ 9:00 am CT, Where: http://www.videonewswire.com/event.asp?id=52343 , ... log on to the web at the ... HCA Healthcare, 615-344-2688, ...
... /Xinhua-PRNewswire-FirstCall/ -- China Sky One,Medical, Inc. ("China Sky ... ), a,leading fully integrated pharmaceutical company producing over-the-counter,drugs ... today that it,recently obtained production approval from the ... two of its newly developed drugs., Sodium ...
... ANGELES, Oct. 30 Cardo Medical, a company ... the FDA 510k,clearance of its Align 360 Total ... planned for commercial release during the second quarter ... the flagship product within,its Align 360 platform which ...
... at 1:30 p.m. (Pacific); ... http://www.adventrx.com , SAN DIEGO, Oct. 30 ADVENTRX Pharmaceuticals,Inc. ... conference call with,simultaneous webcast to discuss third quarter 2008 results on ... Mark N. K.,Bagnall, Executive Vice President and Chief Financial Officer, is ...
... and David,Simon, M.D. in Southern California helps people find relief from stress ... ... investments., SAN DIEGO, Oct. 30 As ... life savings,The Chopra Center for Wellbeing is teaching those impacted how to ...
Cached Medicine News:Health News:Phyhealth Announces Stock Buyback Program 2Health News:Phyhealth Announces Stock Buyback Program 3Health News:China Sky One Medical, Inc. Obtains Production Approval for Two New Drugs 2Health News:Cardo Medical Announces FDA Clearance of the Align 360 Total Knee System 2Health News:Cardo Medical Announces FDA Clearance of the Align 360 Total Knee System 3Health News:Turbulent Times Turn The Chopra Center Into Mecca for Calm 2
(Date:8/29/2014)... 29, 2014  A Boston Scientific Corporation (NYSE: ... stent removability and preliminary long term stricture resolution ... the August issue of the peer-reviewed journal, Gastroenterology. ... is being conducted in 11 countries and five ... metal stents (FCSEMS) after extended indwell (i.e., up ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "China Orthopedic Instrument Industry Report, 2014-2017" report to ... population and rising proportion of reimbursement for medical expenses, ... released, with its scale presenting a CAGR of 19.2% ... are three product segments of orthopedic instruments in ...
(Date:8/29/2014)... 2014 Research and Markets has ... Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018" ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... China,s pharmaceutical equipment industry in the ... landscape, and business performance of domestic major enterprises, as ...
Breaking Medicine Technology:Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4China Orthopedic Instrument Industry Report, 2014-2017 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
... CB1,antagonist rimonabant to show benefits beyond weight reduction ... | March 08, 2007 | The Business Intelligence,firm ... antagonist Acomplia (rimonabant) has at least,five competitors in ... more,in earlier phases of R&D. While Acomplia received ...
... March, 9, 2007-Active Biotech (ACTI.ST), today,announced new positive clinical ... treatment of prostate cancer. , By step-wise dose escalation, ... which corresponds to a doubling of the previously,reported maximum ... a step-wise intra-patient dose-escalation enables a dose,of 1 mg/day ...
Cached Medicine Technology:Weight Management is Not Enough for Cannabinoid Type 1 (CB1),Receptor Antagonists to Become a Commercial Success 2Weight Management is Not Enough for Cannabinoid Type 1 (CB1),Receptor Antagonists to Become a Commercial Success 3Positive Clinical Data for TASQ - Active Biotech's Novel Treatment,of Prostate Cancer 2
... The Leica M520 OH3 ... the best optical performance available ... innovative and unique stand. The ... lightest, has the greatest range ...
Advanced operating microscope with high-resolution apochromatic optics. Senso-servo drive to keep the microscope in perfect balance even if parts are moved or mounted elsewhere....
PS Medical lumboperitoneal catheter systems are designed to divert CSF from the lumbar subarachnoid space to the peritoneal cavity, using simplified surgical techniques....
Curved left, Hardy Curettes, bayonet, working distance 120 mm, total length 241 mm....
Medicine Products: