Navigation Links
Rush University Medical Center scientists home in on cause of osteoarthritis pain
Date:12/27/2012

(CHICAGO)--Researchers at Rush University Medical Center, in collaboration with researchers at Northwestern University, have identified a molecular mechanism central to the development of osteoarthritis (OA) pain, a finding that could have major implications for future treatment of this often-debilitating condition.

"Clinically, scientists have focused on trying to understand how cartilage and joints degenerate in osteoarthritis. But no one knows why it hurts," said Dr. Anne-Marie Malfait, associate professor of biochemistry and of internal medicine at Rush, who led the study. An article describing the research was published in the December 11 print version of the Proceedings of the National Academy of Sciences.

Joint pain associated with OA has unique clinical features that provide insight into the mechanisms that cause it. First, joint pain has a strong mechanical component: It is typically triggered by specific activities (for example, climbing stairs elicits knee pain) and is relieved by rest. As structural joint disease advances, pain may also occur in rest. Heightened sensitivity to pain, including mechanical allodynia (pain caused by a stimulus that does not normally evoke pain, such as lightly brushing the skin with a cotton swab), and reduced pain-pressure thresholds are features of OA.

Malfait and her colleagues took a novel approach to unraveling molecular pathways of OA pain in a surgical mouse model exhibiting the slow, chronically progressive development of the disease. The study was conducted longitudinally, that is, the researchers were able to monitor development of both pain behaviors and molecular events in the sensory neurons of the knee and correlate the data from repeated observations over an extended period.

"This method essentially provides us with a longitudinal 'read-out' of the development of OA pain and pain-related behaviors, in a mouse model" Malfait said.

The researchers as
'/>"/>

Contact: Nancy DiFiore
nancy_difiore@rush.edu
312-942-5159
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Case Western Reserve University receives patient-centered research award
2. The Hong Kong Polytechnic University promotes knowledge enterprises through MAKE Award
3. A Serious Problem: Medical Malpractice Lawyers at Console & Hollawell React to Alarming Doctor Error Statistics from Johns Hopkins University Researchers
4. AED.com Donates LifePak CR Plus AED to Tennessee State University Athletic Department
5. University Hospitals Neurological Institute to present 6th International 2013 Epilepsy Colloquium
6. Rice University opens new window on Parkinsons disease
7. Women’s Excellence in Bladder Control Partners with University Compounding Pharmacy in Troy, MI to Help Women with Chronic Pelvic Pain Conditions
8. Center For Sight Expands Services in University Park; David Hunt, O.D., Becomes Part of Center For Sight’s Comprehensive Eye Care Team
9. Naturecast Pets revisits New Study from University of Adelaide that may Help Dogs with Arthritis
10. University at Buffalo, The State University of New York (SUNY) Goes Live with Osprey’s Conflict of Interest COI RiskManager™
11. University of Southern Mississippi Professor Collaborates with Houston Police for Eyewitness Research Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 2014 LiveStreamingFitness.com, a company dedicated to providing ... lifestyle resources, is proud to announce it has been recognized ... home fitness solutions by ABC’s Good Morning America. ... ABC’s Good Morning America, “Live Streaming Fitness is the hottest ... day by streamlining your workout…to boot camp at Life Streaming ...
(Date:8/30/2014)... 30, 2014 McLeod's Sunset Park Auto ... repair shop with strong ties to the community celebrates sixty ... to announce they have been chosen by The Tampa ... auto repair. , Tim McLeod’s father, Norris (most know ... years ago. Although his son, Tim runs the day to ...
(Date:8/30/2014)... FL (PRWEB) August 30, 2014 Zensah®, the ... Camo Compression Leg Sleeve . The camo sleeves are ... Leg Sleeve collection. The camo line includes classic colors ... and magenta. , Known as tibial stress syndrome, shin ... of the lower leg. Swollen and irritated muscles, stress fractures, ...
(Date:8/30/2014)... 30, 2014 The KSF (Kung Fu ... K.Warrior Search on November 8th, 2014 at the Mobile ... events have introduced many notorious and notable fighters for ... and the UFC. , Among these KSF along ... its doors armed with the virtues of true indomitable ...
(Date:8/30/2014)... Barcelona, Spain Saturday 30 August 2014: The ... today. The novel document compiles current evidence on ... was agreed by international experts from three continents. ... is published today on-line in EP Europace ... European Heart Rhythm Association (EHRA) of the European ...
Breaking Medicine News(10 mins):Health News:LiveStreamingFitness.com is New Trend In Fitness 2Health News:McLeod's Sunset Park Auto Service Celebrates 60 Years Honored with Best of South Tampa 2Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 3Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 4Health News:First expert consensus on ventricular arrhythmias published 2Health News:First expert consensus on ventricular arrhythmias published 3
... say that drinking cherry juice may be the antidote to ... anti-inflammatory compounds that can deal with a number of inflammatory ... Sports Medicine, researchers said that men and women who ate ... in their blood. The study examined 14 male college students ...
... British Food Standards Agency (FSA) has said that one ... is bad news for over 1.3 million Britons// who ... concern since many fast-food restaurants were found to have ... the food. Also infestations of mice, rats, and cockroaches ...
... today joined other nations in a campaign to fight ... millions of patients worldwide. // , ,A ... of Health and Family Welfare in the presence of ... by the Global Patient Safety Challenge, a core programme ...
... have the highest cancer incidences rate compared to that of ... National Cancer Registry Programme (NCRP) has shown.// ,Mizoram ... the figure of Bhopal which had witnessed a horrible gas ... in-charge told a medical conference here today., ,Nagaland and ...
... in this week's BMJ have their say on whether patients ... records.// ,The medical profession is concerned that, in ... no further input from the patient, and this is not ... Cundy and Alan Hassey in a letter to this week's ...
... A sexually transmitted virus that leads to blisters on or ... taking a long period to heal.// As time passes outbreaks ... ,According to U.S. Centers for Disease Control and Prevention, genital ... and even cause serious infection in babies born to mothers ...
Cached Medicine News:Health News:Electronic Patient Record "Serious Threat" to Patient Confidentiality 2
(Date:8/29/2014)... Md. , Aug. 29, 2014  United Therapeutics ... the U.S. District Court for the District of ... favor in the company,s case against Sandoz, Inc. regarding ... Peter Sheridan ruled that U.S. Patent No. ... and enjoined Sandoz from marketing its generic product until ...
(Date:8/29/2014)... Diseases largely eradicated in the United States ... declared eliminated in 2000, yet the CDC reports 593 ... incidence in 20 years. In July, California,s ... problem of "epidemic proportions." Across ... preventable diseases—in part because some parents (more than 10 ...
(Date:8/29/2014)... 2014 Research and Markets has ... Drugs Market 2014-2018" report to their offering. ... condition that results in demyelination, axonal transection, and neurodegeneration. ... response by the immune system, which targets neurons within ... debilitating disease in which the damage of the myelin ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
... , SAN DIEGO, Nov. 18 BeamOne ... beam medical device sterilization service center in the Pittsburgh, ... new facility in Q4 2009, and it is anticipated ... the company,s successful locations in California, Colorado, Ohio, and ...
... , SALT LAKE CITY, Nov. 18 ... VAR ), a premier supplier of X-ray tubes and flat ... and its line of X-ray tubes for fluoroscopy, angiography, cardiology and ... Dusseldorf, Germany from November 18-21, 2009. , The Varian ...
Cached Medicine Technology:BeamOne LLC to Add New Ebeam Sterilization Service Center 2Varian Medical Systems to Showcase the Latest X-Ray Image Detectors and X-Ray Tubes at the MEDICA 2009 International Trade Fair 2
InSIGHT™ Adapter Cable for LATITUDE® Air-Charged Catheter...
Solid State Manometry Catheter Accessory., ,Manometric calibrators are required for calibration of solid state catheters., ,Each type of catheter requires a unique calibrator....
Sphincter of Oddi Solid State Catheter Adapter Cable for Polygraf ID...
... The programmer for the ITREL 3 system ... programmer and the Model 7457 MemoryMod Software ... for the treatment of chronic nausea and ... therapies are not providing adequate relief of ...
Medicine Products: