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Routine breast cancer biopsy might predict lymph node cancer spread
Date:4/18/2010

se malignant cells are seen, additional nodes in the axilla are removed, Cavalli says. "This procedure is performed during the surgery, and the methods currently used to look for tumor cells in these nodes are not ultra sensitive, and may therefore miss these malignant cells especially in the case of micrometastasis."

Cavalli and her team first screened the genomes of cells from both tumors and nodes from the same patient using comparative genome hybridization (CGH), and found that most of the genomic regions affected were similar in both of the samples. . They then used microarray technology (array-CGH) to identify the genes altered in these regions and found several that were altered in patient lymph nodes and tumors. Some of these genes are well known, such as the growth promoting gene her2neu, and the tumor suppressor BRCA1.

"It differed between patients in some, BRCA1 was missing in both samples, in others, Her2neu or other genes were amplified," Cavalli said.

The researchers are now validating their results in other patient samples. "If we can use these genomic markers to identify tumor cells in the sentinel lymph node to reduce the false negative rates that now exist in sentinel node biopsy, we can advance one step forward in patient care," Cavalli says.


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Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

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