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Routine Evaluation of Prostate Size Not as Effective in Cancer Screening, Mayo Study Finds
Date:11/10/2009

ility to look at long-term relationships between prostate growth, change in PSA and development of prostate cancer."

Of the 616 men, 58 (9.4 percent) developed prostate cancer. Men who were diagnosed with prostate cancer had a faster rise in PSA levels (6 percent/year) compared to men who were not diagnosed with cancer (3.3 percent/year). However, the increase in prostate size was similar between these two groups (median change of 2.2 percent/year).

PSA is a substance produced in the prostate gland. Normally, a small amount of PSA enters the bloodstream. A higher amount of PSA or an abrupt rise in PSA levels can indicate a problem, possibly cancer.

"The question we're trying to answer is, if we see a man with a rising PSA level, could this change in PSA be explained by a proportional increase in prostate size?" says Dr. Breau. "Our data indicate that men with or without prostate cancer have similar rates of prostate growth. If a man's PSA is quickly rising, he likely deserves a prostate biopsy to determine if he has prostate cancer. Assessment of change in prostate size should not influence the decision to biopsy."

Other Mayo Clinic researchers involved in this study include: R. Jeffrey Karnes, M.D. (http://www.mayoclinic.org/bio/12463493.html); Debra Jacobson; Michaela McGree; Steven Jacobsen, M.D., Ph.D.; Ajay Nehra, M.D. (http://www.mayoclinic.org/bio/12370606.html); Michael Lieber, M.D.(http://www.mayoclinic.org/bio/10203567.html); and Jennifer St. Sauver, Ph.D.

To request an appointment at Mayo Clinic, please call 480-422-1490 for the Arizona campus, 904-494-6484 for the Florida campus, or 507-216-4573 for the Minnesota campus.

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