Navigation Links
Roundworm quells obesity and related metabolic disorders
Date:4/25/2013

Researchers at the University of Maryland School of Medicine, Baltimore, have shown in a mouse model that infection with nematodes (also known as roundworms) can not only combat obesity but ameliorate related metabolic disorders. Their research is published ahead of print online in the journal Infection and Immunity.

Gastrointestinal nematodes infect approximately 2 billion people worldwide, and some researchers believe up until the 20th century almost everyone had worms. In developed countries there is a decreasing incidence of nematode infection but a rising prevalence of certain types of autoimmunity, suggesting a relationship between the two. Nematode infection has been purported to have therapeutic effects and currently clinical trials are underway to examine worms as a treatment for diseases associated with the relevant cytokines, including inflammatory bowel disease, multiple sclerosis, and allergies.

In the study researchers tested the effect of nematode infection on mice fed a high-fat diet. Infected mice of normal girth gained 15 percent less weight than those that were not infected. Mice that were already obese when infected lost roughly 13 percent of their body weight within 10 days. Infection also drastically lowered fasting blood glucose, a risk factor for diabetes, and reduced fatty liver disease, decreasing liver fat by ~25 percent, and the weight of the liver by 30 percent.

The levels of insulin and leptin also dropped, "indicating that the mice restored their sensitivities to both hormones," says corresponding author Aiping Zhao of the University of Maryland School of Medicine, Baltimore. Leptin moderates appetite. As with too much insulin, too high a level of leptin results in insensitivity, thus contributing to obesity and metabolic syndrome, Zhao explains.

The mechanism of the moderation of these hormones "was associated with a parasite-induced reduction in glucose absorption in the intestine, reduced liver triglycerides, and an increase in the population of cells called "alternatively activated macrophages," which regulate glucose metabolism and inflammation," says coauthor Joe Urban of the United States Department of Agriculture. Some of these changes involved "a protein called interleukin-13 and related intracellular signaling mechanisms," he says. "This suggests that there are immune related shifts in metabolism that can alter expression of obesity and related metabolic syndrome."

The incidence of obesity has been climbing dramatically, worldwide. It is a key risk factor for many metabolic diseases, including diabetes, hypertension, and heart disease. Recent studies indicate that it is accompanied by chronic low-grade inflammation in adipose tissues, causing the release of proinflammatory cytokines and chemokines that contribute to the development of cardiovascular disease and metabolic syndrome.

Parasitic nematode infection induces a marked elevation in host immune Th2-cells and related type 2 cytokines which, besides combating the infection, also have potent anti-inflammatory activity, according to the report.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Roundworm Infections Threaten Organ Recipients
2. Lean On Life Encourages a New “Fat Tax” to Help Defeat Obesity
3. Obesity Linked to Prostate Cancer, Study Finds
4. Teen Births May Increase Risk of Obesity Later in Life
5. American Society of Nutrition to host symposium on the impact of sweetened beverages on obesity
6. ACP unveils tools to improve care for patients with prediabetes, gout, obesity, and Alzheimers
7. Penn study finds increased sleep could reduce rate of adolescent obesity
8. When Teens Focus on TV, Obesity Risk Rises
9. Recent Research Findings Suggest that Weight Loss Supplements Like Clear Cleanse Pro May Remove “Obesity Microorganisms” from Your Body
10. Study Locates More Obesity Genes
11. Obesity Does Slow People Down, Study Confirms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... KY (PRWEB) , ... April 25, 2017 , ... ... announce they have signed an agreement to be the preferred physical therapy provider ... injuries and returning them to Derby City CrossFit as quickly and effectively as ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... compare student test score performance for the 2015-16 school year across Wisconsin’s public ... programs. Though it highlights important patterns in student test score performance, the report’s ...
(Date:4/25/2017)... ... 25, 2017 , ... As pharmaceutical companies are held to ... process innovation in drug formulation and manufacturing. CoreRx offers its clients more ... in support of their development and manufacturing goals. , The company was ...
(Date:4/25/2017)... ... April 25, 2017 , ... Saad B. Chaudhary, MD is committed to providing the ... or chronic problems, I focus on preventative care with all my patients to alleviate possible ... questions, always feel free to contact my office and my trained staff will assist you ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol USA® , a ... UCII, part of the EQUISTRO line, at this week’s Rolex Kentucky Three-Day Event ... the immunologic level. , The scientifically-developed Flexadin UCII supports the body’s normal repair ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced that it will be participating ... Conference at the InterContinental Hotel in Boston, ... Biomet will present at 11:20 a.m. Eastern Time. ... accessed via Zimmer Biomet,s Investor Relations website at ...
(Date:4/20/2017)... -- Research and Markets has announced the addition of ... Expanding Injectables Market and Increasing Usage of Complex Biologics during the ... ... from USD 20 Billion in 2015 to around USD 26 Billion ... Innovation Driven by Rapidly Expanding Injectables Market and Increasing Usage of ...
(Date:4/20/2017)...  AbbVie (NYSE: ABBV), a global biopharmaceutical company, ... hepatitis C virus (HCV) infected patients with genotype ... cirrhosis (Child-Pugh A) achieved sustained virologic response at ... investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). These high ... weeks of G/P treatment without ribavirin. Patients with ...
Breaking Medicine Technology: