Navigation Links
Roundworm Infections Threaten Organ Recipients
Date:4/11/2013

THURSDAY, April 11 (HealthDay News) -- Three people who received transplant organs in 2012 from the same 24-year-old donor got more than they bargained for: Each developed a severe roundworm infection, U.S. health officials reported Thursday.

The transplant recipients acquired Strongyloides, an infection caused by an intestinal parasite common in the tropics and subtropics known as S. stercoralis. The infection apparently was transmitted from the donated organ to the recipients, according to a report from the U.S. Centers for Disease Control and Prevention.

The discovery could lead to new guidelines for organ transplantations, the report suggested. Doctors currently recommend screening recipients for Strongyloides if they come from areas where the parasitic worms are widespread, but this report suggests a need to screen donors as well.

"Donor-derived Strongyloides infection might be more common than previously believed," the CDC report said. "In these investigations, a single donor was the source of infection for three of four organ recipients."

If screening identifies donor infection, preventive treatment of vulnerable recipients can begin, the CDC said in its April 12 Morbidity and Mortality Weekly Report. Organ recipients are at high risk of serious infection because of the immune-system-suppressing drugs they take to fight rejection of their new organ.

Among healthy people, the roundworm infection can present no symptoms, but experts believe the immunosuppressive therapy might reactivate chronic infection in the transplanted organs.

The donor in this case died of gunshot wounds. The next day, his heart, kidneys, pancreas and liver were transplanted into four recipients. The donor was born in Puerto Rico and often visited there, but at the time of donation Strongyloides was not suspected. That's probably because most cases in North America are seen in people who have visited or lived in South America or Africa, the CDC report said.

One of the recipients, a 64-year-old man, developed severe nausea, loss of appetite and abdominal swelling nine weeks after receiving a pancreas and kidney. Stool samples, urine samples and biopsies uncovered S. stercoralis -- both adult worms and larvae.

Doctors then followed up with a 14-year-old kidney recipient 10 weeks after his transplant and found he had a fever, rash, loss of appetite, nausea, vomiting and diarrhea. Testing revealed that he, too, had the roundworm infection.

Both recovered after treatment with antiparasitic medications.

But a heart recipient who was found to have S. stercoralis larvae in his respiratory system died 11 weeks after his transplant. The CDC report didn't state, however, that the infection caused the 59-year-old's death. The liver recipient, 66, also died, but an autopsy showed no signs of the parasitic infection.

Besides donor screening for Strongyloides, the CDC recommended improved communication to protect transplant patients.

"Rapid communication among transplant centers and organ-procurement organizations is also vital to protect organ recipients when there is a concern for disease transmission," the report stated.

More information

The U.S. National Library of Medicine has more about Strongyloides.

SOURCE: U.S. Centers for Disease Control and Prevention, Morbidity and Mortality Weekly Report, April 12, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. RI Hospital: Co-infections not associated with worse outcomes during H1N1 pandemic
2. Copper surfaces reduce the rate of health care-acquired infections in the ICU
3. Study: Hospital infections in cancer patients climbed, deaths declined
4. Michigan hospitals national leaders in preventing common and costly urinary tract infections
5. Steady Rise in Heart Valve Infections Noted in U.S.
6. Craze for Hairless Genitals Accompanies Rise in Infections
7. Flu Infections Continue to Decline
8. Community-based HIV-prevention efforts can boost testing, help reduce new infections
9. Very low risk of infections in advanced brain procedures
10. Merck scientist Daria Hazuda presents Bernard Fields Lecture at 20th Conference on Retroviruses and Opportunistic Infections (CROI)
11. Kids, Seniors Prone to MRSA Infections Depending on Season: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... MEDI+SIGN®, ... announced today that a new solution for Emergency Departments (ED) has been added ... space in Emergency Department examination rooms, and with a simplified pallet of information ...
(Date:12/8/2016)... ... 08, 2016 , ... After enjoying record-breaking attendance at its ... its 33rd Annual Issues & Research Conference, March 2-3, 2017, at the ... conference is “Persistent Challenges and New Opportunities: Using Research to Accelerate the Dialogue." ...
(Date:12/8/2016)... Plainsboro, NJ (PRWEB) , ... December 08, 2016 , ... ... patients, cancer centers and advocacy groups, has aligned with Upstage Lung Cancer in efforts ... In making the announcement, Michael J. Hennessy, Jr said, “CURE Media Group is honored ...
(Date:12/8/2016)... ... December 08, 2016 , ... Launching of ... Unified Instance Manager architecture, meeting the needs of multichannel growth and doubling ... unattended auto-dialing system without agents, Presence Robodialer, provides greater operational capacity, administrative ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s patients are encouraged ... in mind, SIGVARIS has created a new line of anti-embolism stockings to help ... provide the benefits of graduated compression when transitioning from recovery to early rehabilitation. ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Dec 9, 2016 Research and Markets ... 2016-2020" report to their offering. ... The report forecasts the global optical transceiver ... 2016-2020. The report covers the present scenario and ... To calculate the market size, the report considers the revenue generated ...
(Date:12/9/2016)... Dec. 9, 2016  Harmar Mobility, LLC announced today that Steven ... of the Board of Directors. Photo - http://photos.prnewswire.com/prnh/20161209/447552 ... ... Mr. Dawson,s executive career includes ... across a variety of industries. He brings to the company deep ...
(Date:12/9/2016)... Dec. 9, 2016 aTyr Pharma, Inc. (Nasdaq: ... of Physiocrine-based therapeutics to address severe, rare diseases, today announced that ... BMO Prescriptions for Success Healthcare Conference at the InterContinental Barclay Hotel ... 14, 2016, at 4:20 p.m. ET. About aTyr ... aTyr ...
Breaking Medicine Technology: