Navigation Links
Roundworm Infections Threaten Organ Recipients
Date:4/11/2013

THURSDAY, April 11 (HealthDay News) -- Three people who received transplant organs in 2012 from the same 24-year-old donor got more than they bargained for: Each developed a severe roundworm infection, U.S. health officials reported Thursday.

The transplant recipients acquired Strongyloides, an infection caused by an intestinal parasite common in the tropics and subtropics known as S. stercoralis. The infection apparently was transmitted from the donated organ to the recipients, according to a report from the U.S. Centers for Disease Control and Prevention.

The discovery could lead to new guidelines for organ transplantations, the report suggested. Doctors currently recommend screening recipients for Strongyloides if they come from areas where the parasitic worms are widespread, but this report suggests a need to screen donors as well.

"Donor-derived Strongyloides infection might be more common than previously believed," the CDC report said. "In these investigations, a single donor was the source of infection for three of four organ recipients."

If screening identifies donor infection, preventive treatment of vulnerable recipients can begin, the CDC said in its April 12 Morbidity and Mortality Weekly Report. Organ recipients are at high risk of serious infection because of the immune-system-suppressing drugs they take to fight rejection of their new organ.

Among healthy people, the roundworm infection can present no symptoms, but experts believe the immunosuppressive therapy might reactivate chronic infection in the transplanted organs.

The donor in this case died of gunshot wounds. The next day, his heart, kidneys, pancreas and liver were transplanted into four recipients. The donor was born in Puerto Rico and often visited there, but at the time of donation Strongyloides was not suspected. That's probably because most cases in North America are seen in people who have visited or lived in South America or Africa, the CDC report said.

One of the recipients, a 64-year-old man, developed severe nausea, loss of appetite and abdominal swelling nine weeks after receiving a pancreas and kidney. Stool samples, urine samples and biopsies uncovered S. stercoralis -- both adult worms and larvae.

Doctors then followed up with a 14-year-old kidney recipient 10 weeks after his transplant and found he had a fever, rash, loss of appetite, nausea, vomiting and diarrhea. Testing revealed that he, too, had the roundworm infection.

Both recovered after treatment with antiparasitic medications.

But a heart recipient who was found to have S. stercoralis larvae in his respiratory system died 11 weeks after his transplant. The CDC report didn't state, however, that the infection caused the 59-year-old's death. The liver recipient, 66, also died, but an autopsy showed no signs of the parasitic infection.

Besides donor screening for Strongyloides, the CDC recommended improved communication to protect transplant patients.

"Rapid communication among transplant centers and organ-procurement organizations is also vital to protect organ recipients when there is a concern for disease transmission," the report stated.

More information

The U.S. National Library of Medicine has more about Strongyloides.

SOURCE: U.S. Centers for Disease Control and Prevention, Morbidity and Mortality Weekly Report, April 12, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. RI Hospital: Co-infections not associated with worse outcomes during H1N1 pandemic
2. Copper surfaces reduce the rate of health care-acquired infections in the ICU
3. Study: Hospital infections in cancer patients climbed, deaths declined
4. Michigan hospitals national leaders in preventing common and costly urinary tract infections
5. Steady Rise in Heart Valve Infections Noted in U.S.
6. Craze for Hairless Genitals Accompanies Rise in Infections
7. Flu Infections Continue to Decline
8. Community-based HIV-prevention efforts can boost testing, help reduce new infections
9. Very low risk of infections in advanced brain procedures
10. Merck scientist Daria Hazuda presents Bernard Fields Lecture at 20th Conference on Retroviruses and Opportunistic Infections (CROI)
11. Kids, Seniors Prone to MRSA Infections Depending on Season: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the ... as Vice President of North American Capital Sales at HTG Molecular . ... team in the commercialization of the HTG EdgeSeq system and associated reagents in North ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: