Navigation Links
Rotigotine Skin Patch May Ease Restless Legs Symptoms
Date:5/30/2008

But one expert notes problems with manufacturing, unreliable delivery of the drug

FRIDAY, May 30 (HealthDay News) -- Skin patches that contain the drug rotigotine help relieve restless legs syndrome (RLS), according to a German study.

Dopaminergic drugs -- which stimulate the body's dopamine system -- are currently used as a first-line treatment for RLS, and rotigotine is already used to treat Parkinson's disease. This study of 458 people with moderate to severe RLS examined the efficacy of rotigotine skin patches.

The patients were randomly assigned to apply skin patches with 1 milligrams of rotigotine (115 patients), 2 milligrams (112), or 3 milligrams (114) once a day for six months. A fourth group of 117 patients received a placebo.

The patients were assessed using the International Restless Leg Syndrome study group severity rating scale (IRLS) and the clinical global impressions (CGI) item 1 score, which measures severity of symptoms. At the start of the study, the patients' average IRLS score was 28.1, and their average CGI item 1 score was four or more.

At the end of the study, mean changes in IRLS score were: -13.7 in the 1 mg group; -16.2 in the 2 mg group; -16.8 in the 3 mg group; and -8.6 in the placebo group. Changes in the CGI item 1 score were: -2.09 in the 1 mg group; -2.41 in the 2 mg group; -2.55 in the 3 mg group; and -1.34 in the placebo group.

Of the 341 patients who used the rotigotine skin patches, 145 (43 percent) experienced skin reactions (mostly mild or moderate), compared to two of 117 (2 percent) of those who received the placebo.

Ten patients suffered serious side effects related to rotigotine: elevation of liver enzymes (1 patient); worsening of tinnitus (1); non-response to anticoagulation (1); electrocardiogram changes (1); and skin patch application site reactions (6). All the skin reactions resolved within a short time after the patch was removed.'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Patch Form of HRT Poses Less Clotting Risks Than Pill Does
2. The First QPatch HT in China Placed in WuXi PharmaTech (NYSE: WX)
3. Iomai Wins Department of Defense Grant to Develop a Stable, Patch-Based Anthrax Vaccine
4. Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels
5. Mylan Confirms Its Matrix Design Fentanyl Patch Is Not Included In the Widespread Recall Announced February 12th
6. PriCara(TM) Recalls 25 mcg/hr DURAGESIC(R) (fentanyl transdermal system) CII Pain Patches
7. Iomai Study Shows Self-Applied Travelers Diarrhea Vaccine Patch Comparable to Clinician-Applied Vaccine Patch
8. Ringing endorsement: Women prefer contraceptive ring over patch
9. FDA Warns Clot Risk Higher in Birth Control Patch Than Pill
10. FDA Renews Warnings on Pain-Relief Patch
11. Studies of 20,000 smokers show quit rates double with counseling and free nicotine patches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... a well-known casket manufacturer from China, has announced its newest ... executive officer has announced a new promotion for its funeral ... prices, from 15 to 26 percent off. , “As far ... in the current market. We are excited to release the ... high quality products for sale. Many of our clients are ...
(Date:7/13/2014)... Micro irrigation systems are mainly utilized for ... wells as to maintain soil quality. The application of ... a dominant revenue generator for manufacturers in future. The ... costs has led to the adoption of micro irrigation ... caused massive demand for micro irrigation systems, as they ...
(Date:7/13/2014)... 2014 Fuel additives are chemicals, which ... jet fuel, kerosene, and so on, in order to ... reducing the corrosion effects caused by fuels and improving ... any fuel, provide economies of scale in the long ... overall cost of the fuel products. , The various ...
(Date:7/13/2014)... New York, New York (PRWEB) July 13, 2014 ... much to bring attention to the cancer risks associated ... a chance to tell their story to federal regulators, ... of a U.S. Food & Drug Administration (FDA) ... Liebhard LLP reports. According to the Rochester Democrat ...
(Date:7/13/2014)... 13, 2014 Athletes with a certain ... from concussions, according to research presented today at the ... Annual Meeting. The research marks the first of its ... the known physical events that occur after a head ... long allele in the (GT)n genotype were four times ...
Breaking Medicine News(10 mins):Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2
... ST. LOUIS: Following Advanced Medical Optics' voluntary recall ... lens solution, doctors of optometry from the ... Section concur with the company's decision to remove ... has not been officially determined, health officials from ...
... Biochemical Zoology, a fascinating new selection of papers ... selection, providing insight into how organisms adapt ... ,Dr. James Hicks, Editor in Chief of PBZ, ... "This exciting approach experimental evolution allows ...
... against the myriad strains of the human immunodeficiency virus ... study conducted at the Uniformed Services University of the ... extremely variable, its prevention requires a vaccine effective enough ... can neutralise multiple viral strains. ,The ...
... new study has found that being exposed to pesticides, as ... of developing Parkinsons. ,The study, which is published ... Medicine, one of the BMJ Specialty Journals, states that the ... ,959 people suffering with Parkinsons, as well as 1,989 controls ...
... new research has found that HIV and malaria combine ... ,University of Toronto researchers have exposed the ... and have also discovered how the HIV virus works ... superior vaccines for pregnant women in malaria-ravished regions. ...
... Early data for an investigational device that specifically targets ... , called Tumor-Treating Fields (TTFields), has found that it ... patients with the most common and aggressive type of ... Novo-TTF, uses electrical fields to disrupt tumor growth by ...
Cached Medicine News:Health News:Optometrists Support AMO's Voluntary Contact Lens Solution Recall 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2Health News:Risk of Parkinsons Increased by Exposure to Pesticide and Head Trauma 2Health News:Malaria and HIV Jointly Affects Pregnant Women and Their Infants 2Health News:Device That Targets Brain Cancer Shows Promising Results 2
(Date:7/10/2014)... July 10, 2014   Ventana Medical Systems, Inc. ... it has entered into an agreement with Merck KGaA, ... EMD Serono in the United States ... with Merck KGaA,s biopharmaceutical division on the development and ... target using Ventana,s proprietary diagnostic assays. In alignment with ...
(Date:7/10/2014)... Decision Resources Group finds that over half ... and Drug Administration,s (FDA) approval of Vifor Fresenius Medical ... approved by the FDA in November 2013 for the ... on dialysis. Other key findings from the ... : , Bundling: ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... Feb. 8, 2011 The District of Columbia Patients Cooperative ... to provide high quality and affordable medical "marijuana" to qualifying ... implementation of DC,s new medical marijuana program.  The public meeting ... place on Thursday, February 10th at 7:00 pm in Pierce ...
... TUCSON, Ariz., Feb. 8, 2011 MRI Medical Inc. ... as part of its corporate development plan. ... provide our customers with the same superior design, development, ... years," stated Joseph Lee, Xeridiem Medical Devices, Inc.,s President. "Our ...
Cached Medicine Technology:February 10 Town Hall Meeting to Explain DC's New Medical Marijuana Program 2MRI Medical Inc. Changing Name to Xeridiem Medical Devices, Inc. 2
... is designed to augment areas ... midface, including the inferior orbital ... in the hollow under the ... implant aids in restoring the ...
Flattened points in vertical plane, straight shafts, cross action, round handle....
Karate chopper, spear shaped for ease of insertion into the nucleus....
Round serrated handle, dull finish....
Medicine Products: