Navigation Links
Rothman Institute at Jefferson research suggests use of LE strips to diagnose PJI
Date:2/7/2012

PHILADELPHIA Rothman Institute at Jefferson joint researchers continue to seek better ways to diagnose and subsequently treat periprosthetic joint infection (PJI) in patients following total joint arthroplasty. Their latest research shows leukocyte esterase reagent (LE) strips, common in diagnosing urinary tract infections, can also have a role in rapid diagnosis of PJI.

The prospective study built on previous work conducted by Javad Parvizi, MD, FRCS, director of Research at the Rothman Institute and Professor of Orthopedics at Jefferson Medical College, and fellow researchers to develop a better, faster way to diagnose PJI.

Our continued research will help us get to the root cause of PJI and therefore enable us to diagnose this terrible condition expeditiously, inexpensively, and with minimal risk to patients, said Parvizi.

Their latest findings on the use of LE strips will be presented at the American Academy of Orthopedic Surgeons annual meeting in San Francisco on Tuesday, February 7th at 8:54 am Pacific Time.

PJI continues to be a concern for the industry as antibiotic-resistance organisms have increased the prevalence of post-surgical periprosthetic infections. Deep periprosthetic joint infection is currently the most common indication for revision of total knee arthroplasty and the third most frequent indication for revision of total hip arthroplasty.

The team hypothesized that more than the neutrophils themselves; it is the enzymes they secrete that may be better markers for infection. They tested the sensitivity and specificity of a method for detecting one of those enzymes, leukocyte esterase. Esterase is an enzyme released by white blood cells and is associated with other types of bacterial infections, including urinary tract infections.

They performed intraoperative aspirations on 117 patients between 2007 and 2009 and tested for the presence of leukocyte esterase using a simple colorimetric strip test. Color change, denoting the presence and level of enzyme, was recorded.

Of those tested, 23 were determined to be infected and 94 were determined to be uninfected. When using the highest level of infection as the threshold for a positive test, the test was 86.4 percent sensitive for infection and 95.8 percent specific for esterase, and when using smallest level of detected infection as threshold, the test was found to be 59.9 percent sensitive and 98.8 percent specific, showing that testing for leukocyte esterase in the synovial fluid is a valuable addition to the diagnostic armamentarium for PJI. LE strips also aid in rapid testing. While this is our first test of LE strips for use in diagnosing PJI, our findings show the test to be accurate for detecting infection in the synovial fluid. This is encouraging as we continue in our research to better understand, detect and treat PJI in our patients, said Parvizi.


'/>"/>

Contact: Lee-Ann Landis
leeann.landis@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Fogarty Institute for Innovation launches advanced endovascular training fellowship
2. Hormel Institute study makes key finding in stem cell self-renewal
3. Childhood cancer research grant awarded to the Research Institute at Nationwide Childrens Hospital
4. Van Andel Research Institute findings provide more complete picture of kidney cancer
5. Wyss Institute founding director, Donald Ingber, M.D., Ph.D., receives 2011 Holst Medal
6. Trudeau Institute announces latest discovery in vaccine development
7. Huntsman Cancer Institute awarded top honors as cancer imaging facility
8. Van Andel Institute study may lead to better, safer drug for diabetes
9. Jeopardy! winnings spur IBM and Scripps Research Institute collaboration to fight against malaria
10. Mass. General Cancer Center and Vall dHebron Institute of Oncology biomarker alliance
11. US institute wraps up data collection in Russian Mars 520-day mission simulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
Breaking Medicine Technology: