PHILADELPHIA Rothman Institute at Jefferson joint researchers continue to seek better ways to diagnose and subsequently treat periprosthetic joint infection (PJI) in patients following total joint arthroplasty. Their latest research shows leukocyte esterase reagent (LE) strips, common in diagnosing urinary tract infections, can also have a role in rapid diagnosis of PJI.
The prospective study built on previous work conducted by Javad Parvizi, MD, FRCS, director of Research at the Rothman Institute and Professor of Orthopedics at Jefferson Medical College, and fellow researchers to develop a better, faster way to diagnose PJI.
Our continued research will help us get to the root cause of PJI and therefore enable us to diagnose this terrible condition expeditiously, inexpensively, and with minimal risk to patients, said Parvizi.
Their latest findings on the use of LE strips will be presented at the American Academy of Orthopedic Surgeons annual meeting in San Francisco on Tuesday, February 7th at 8:54 am Pacific Time.
PJI continues to be a concern for the industry as antibiotic-resistance organisms have increased the prevalence of post-surgical periprosthetic infections. Deep periprosthetic joint infection is currently the most common indication for revision of total knee arthroplasty and the third most frequent indication for revision of total hip arthroplasty.
The team hypothesized that more than the neutrophils themselves; it is the enzymes they secrete that may be better markers for infection. They tested the sensitivity and specificity of a method for detecting one of those enzymes, leukocyte esterase. Esterase is an enzyme released by white blood cells and is associated with other types of bacterial infections, including urinary tract infections.
They performed intraoperative aspirations on 117 patients between 2007 and 2009 and tested for the presence of leukocyte esterase using a simple colorimetric strip test. Col
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Thomas Jefferson University