New study finds that family history data supports heredity's role in shoulder tendon tears
ROSEMONT, Ill., May 1 /PRNewswire-USNewswire/ -- People with relatives who have experienced rotator cuff tears are at increased risk of similar tendon tears themselves, according to a study published in the May 2009 issue of The Journal of Bone and Joint Surgery (JBJS). "This strongly suggests genetic predisposition as a possible cause for rotator cuff disease," said Robert Z. Tashjian, MD, associate professor of orthopaedic surgery,
By using the Utah Population Database combined with the
"While we have not determined the exact genetic component," said Dr. Tashjian, "Our family history data supports that heredity plays a role in the development of rotator cuff tearing."
This problem usually affects people in their 50s and 60s. It is believed to have both mechanical and environmental influences; however, scientists unclear as to exactly why it occurs, have several theories including:
The potential impact of this research is that it is a springboard for attempting to identify an exact genetic component for this injury. Dr. Tashjian and his colleagues are currently collecting blood samples for DNA analysis of patients with rotator cuff tears, which will be used later for various genetic analyses to determine the exact genetic component.
The results of this research have potential long term implications, including:
While an exercise program would not completely prevent development of rotator cuff disease, it may limit the negative impact on shoulder function.
The research results can also lead to future treatment options. "Rotator cuff healing is often incomplete and identifying a possible genetic link to the disease may provide targets for biologic treatments to improve the healing rates," noted Dr. Tashjian.
More Information: The Utah Population Database is a multigenerational database including, birth, death and family history data on over 10 million individuals. The
Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the National Institutes of Health-National Library of Medicine (NLM R01 LM009331). Partial support less than $10,000 for all datasets within the Utah Population Database was provided by the
|SOURCE The Journal of Bone and Joint Surgery|
Copyright©2009 PR Newswire.
All rights reserved