Navigation Links
Rotator Cuff Tears: Are They All in the Family?
Date:5/1/2009

New study finds that family history data supports heredity's role in shoulder tendon tears

ROSEMONT, Ill., May 1 /PRNewswire-USNewswire/ -- People with relatives who have experienced rotator cuff tears are at increased risk of similar tendon tears themselves, according to a study published in the May 2009 issue of The Journal of Bone and Joint Surgery (JBJS). "This strongly suggests genetic predisposition as a possible cause for rotator cuff disease," said Robert Z. Tashjian, MD, associate professor of orthopaedic surgery, University of Utah School of Medicine Orthopaedic Center in Salt Lake City.

By using the Utah Population Database combined with the University of Utah Health Sciences Data Warehouse numbers, researchers found an increased risk for these tears in family members of patients with rotator cuff tears. The risk extends out and beyond third-cousin relationships (Third cousins are the great-great-grandchildren of one's great-great-grandparents.)

"While we have not determined the exact genetic component," said Dr. Tashjian, "Our family history data supports that heredity plays a role in the development of rotator cuff tearing."

This problem usually affects people in their 50s and 60s. It is believed to have both mechanical and environmental influences; however, scientists unclear as to exactly why it occurs, have several theories including:

  • Decreased blood flow leading to tendon dysfunction and tearing
  • Bumping (impingement) of the rotator cuff on the undersurface of the shoulder cap (acromion) when moving the arm
    • This may lead to a slow development of tears due to repetitive micro-trauma over time
  • Age-related degeneration

The potential impact of this research is that it is a springboard for attempting to identify an exact genetic component for this injury. Dr. Tashjian and his colleagues are currently collecting blood samples for DNA analysis of patients with rotator cuff tears, which will be used later for various genetic analyses to determine the exact genetic component.

The results of this research have potential long term implications, including:

  • Prevention
    • Knowing about a family history of rotator cuff disease can alert patients to take some precautionary measures to protect against their own injuries
    • Orthopaedic surgeons can initiate a shoulder stretching and strengthening program for patients to help limit the effects of possible future rotator cuff problems

While an exercise program would not completely prevent development of rotator cuff disease, it may limit the negative impact on shoulder function.

The research results can also lead to future treatment options. "Rotator cuff healing is often incomplete and identifying a possible genetic link to the disease may provide targets for biologic treatments to improve the healing rates," noted Dr. Tashjian.

More Information: The Utah Population Database is a multigenerational database including, birth, death and family history data on over 10 million individuals. The University of Utah Health Sciences Data Warehouse includes all medical record information on more than two million individuals evaluated and treated at the University of Utah. The combined database allows a hereditary analysis of any piece of the medical record of these individuals stored in the Data Warehouse.

Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the National Institutes of Health-National Library of Medicine (NLM R01 LM009331). Partial support less than $10,000 for all datasets within the Utah Population Database was provided by the University of Utah Huntsman Cancer Institute. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

JBJS

AAOS

More information about the AAOS


'/>"/>
SOURCE The Journal of Bone and Joint Surgery
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Long-term outlook good for rotator cuff repairs
2. Genes May Help Drive Rotator Cuff Injury
3. Smith & Nephew Endoscopys KINSA(R) RC Suture Anchor Designed for Secure Repair of Rotator Cuff Injuries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... America . ... ... ... ...
Breaking Medicine Technology: