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Romosozumab signif increases bone mineral density and bone content compared with teriparatide
Date:6/11/2014

mineral content gains were also larger with romosozumab compared with teriparatide at both the lumbar spine (23.3% vs. 10.9%, P<0.0001) and hip (3.4% vs. 0.0%, P=0.03).

Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. Romosozumab, a monoclonal antibody which binds to sclerostin, stimulates bone formation and decreases bone resorption.

"Because the gene that encodes sclerostin is primarily expressed in skeletal tissue, sclerostin inhibition provides an attractive mechanism of action. More precise targeting should limit the range of side effects, thereby offering a promising new approach to the treatment of post-menopausal osteoporosis," explained Professor Genant.

"The use of teriparatide, an effective anabolic agent which can stimulate bone growth and reduce the risk of fractures, is potentially problematic due to the requirement for daily subcutaneous injection, its relatively high cost, and also a black-box warning about the risk of inducing osteosarcoma in rats," Professor Genant concluded.

Post-menopausal osteoporosis is considered a serious public health concern due to its high prevalence worldwide. Approximately 30% of all postmenopausal women have osteoporosis in Europe and the US; at least 40% of these women will go on to sustain one or more fragility fractures in their lifetime.2

The most common fractures associated with post-menopausal osteoporosis occur at the hip, spine and wrist.3 Of particular concern are vertebral (spinal) and hip fractures. Vertebral fractures can result in intense back pain and deformity. A hip fracture usually requires surgery and may result in loss of independence, or even death in an elderly frail patient.3

This international, randomised, placebo-controlled, phase 2 study enrolled postmenopausal women 55-85 years old with lumbar spine, total hip, or femoral neck T-score ≤𔃀.0 and ≥𔃁.5 at all sites. Quantitative computed tomography
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Contact: EULAR Press Office
eularpressoffice@cohnwolfe.com
44-078-801-73209
European League Against Rheumatism
Source:Eurekalert

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