Navigation Links
Role of estrogen in colon cancer prevention, treatment studied at UH

HOUSTON, Oct. 21, 2013 As the second leading cause of cancer-related deaths in the U.S., colon cancer affects both men and women and is expected to cause more than 50,000 deaths this year. University of Houston (UH) professor Cecilia Williams has been awarded a $1.56 million grant from the National Cancer Institute (NCI) to investigate the mechanistic basis for novel colon cancer prevention and therapy.

While a truly preventive or targeted therapy against colon cancer does not yet exist, estrogen has been shown to reduce incidence of this disease. Williams, an assistant professor with the UH Center for Nuclear Receptors and Cell Signaling (CNRCS), plans to provide a detailed understanding of the role and potential of the nuclear receptor estrogen receptor beta (ERbeta) in colon cancer prevention and treatment.

A large body of work has suggested that signals conveyed by estrogen can prevent or delay colon cancer development, but little is understood of the underlying mechanisms. Williams' lab offers unique models and data that can clarify how estrogen influences colon cancer development. Through this five-year project, the lab will investigate the mechanistic basis for novel colon cancer prevention and therapy using ERbeta to validate biomarkers and develop future therapy and prevention strategies.

"Our preliminary studies, performed with the help of graduate students Karin Edvardsson, Trang Vu and Philip Jonsson, have yielded positive results, and we look forward to expanding upon our research with this this NCI grant," Williams said. "Our goal is to increase opportunities for improved colon cancer prevention and therapies."

This work also involves experts within related fields, including Jonna Frasor at the University of Illinois at Chicago, who studies estrogen and inflammation in the breast; Dr. Christopher Garrett at the University of Texas M.D. Anderson Cancer Center, a colon cancer clinician; Preethi Gunaratne, a bioinformatics researcher and professor in the UH College of Natural Sciences and Mathematics; and UH CNRCS Director Dr. Jan-ke Gustafsson, who discovered ERbeta in the mid-1990s.

The National Cancer Institute (NCI) is part of the National Institutes of Health (NIH), which is one of 11 agencies that compose the Department of Health and Human Services. The NCI, established under the National Cancer Institute Act of 1937, is the Federal Government's principal agency for cancer research and training.


Contact: Lisa Merkl
University of Houston

Related medicine news :

1. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
2. Genetic markers for testosterone and estrogen level regulation identified
3. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
4. Estrogen helps keep joint pain at bay after hysterectomy
5. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
6. Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
7. Estrogen fuels autoimmune liver damage
8. NuvaRing Lawsuits Move Forward, as Federal Judge Rules that Plaintiffs’ Experts May Testify on “Bursts” of Estrogen Allegedly Delivered by NuvaRing, Wright & Schulte LLC
9. Exercise-related changes in estrogen metabolism may lower breast cancer risk
10. Estrogen Levels Tied to Risk for Sudden Cardiac Death in Study
11. New Stool Test Might Aid in Early Detection of Colon Cancer
Post Your Comments:
Related Image:
Role of estrogen in colon cancer prevention, treatment studied at UH
(Date:12/1/2015)... TX (PRWEB) , ... December 01, 2015 , ... Dr. ... of Vitenas Cosmetic Surgery, has been named by MedEsthetics magazine as the Best Single ... of the best among the many elite aesthetic physicians honored by the industry publication. ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... have seen vast improvements in scientific research and discoveries, leading us to better ... hope and relief to those affected by HIV/AIDS. Mediaplanet’s cross-platform edition of “World ...
(Date:12/1/2015)... ... December 01, 2015 , ... Diabetic foot ... States. Podiatrists are well aware that psychology-based patient non-compliance (disobedience of a health ... contributors to diseases of the diabetic foot. The American Board of Multiple ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... , Visage Imaging Inc. (“Visage”), a wholly owned subsidiary of Pro Medicus Ltd. ... results enhancements at the Radiological Society of North America (RSNA) 2015 annual meeting ...
(Date:12/1/2015)... ... ... Lutronic, a leading innovator of aesthetic and medical laser and energy-based technology, announced ... the United States. Clarity is a Superior Dual Wavelength Platform which combines two ... platform that is easy to own and operate. , For over a decade, ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Ohio , Dec. 1, 2015 ... to its GeneSight® Psychotropic test giving healthcare providers an ... medication decisions for patients suffering from depression, anxiety, ... other behavioral health conditions. i ... --> With the addition of two ...
(Date:12/1/2015)... 2015 --> ... "Nucleic Acid Labeling Market by Product (Reagents & Kits, ... In Vitro Transcription, Reverse Transcription, End Labeling), by Region ... global market is expected to reach USD 1,925.7 Million ... at a CAGR of 8.65%. Browse 77 ...
(Date:12/1/2015)... , Dec. 01, 2015 ... the "Veterinary Equipment and Disposables Market by ... report to their offering. --> ... "Veterinary Equipment and Disposables Market by product, ... report to their offering. --> Research ...
Breaking Medicine Technology: