Navigation Links
Role of estrogen in colon cancer prevention, treatment studied at UH
Date:10/21/2013

HOUSTON, Oct. 21, 2013 As the second leading cause of cancer-related deaths in the U.S., colon cancer affects both men and women and is expected to cause more than 50,000 deaths this year. University of Houston (UH) professor Cecilia Williams has been awarded a $1.56 million grant from the National Cancer Institute (NCI) to investigate the mechanistic basis for novel colon cancer prevention and therapy.

While a truly preventive or targeted therapy against colon cancer does not yet exist, estrogen has been shown to reduce incidence of this disease. Williams, an assistant professor with the UH Center for Nuclear Receptors and Cell Signaling (CNRCS), plans to provide a detailed understanding of the role and potential of the nuclear receptor estrogen receptor beta (ERbeta) in colon cancer prevention and treatment.

A large body of work has suggested that signals conveyed by estrogen can prevent or delay colon cancer development, but little is understood of the underlying mechanisms. Williams' lab offers unique models and data that can clarify how estrogen influences colon cancer development. Through this five-year project, the lab will investigate the mechanistic basis for novel colon cancer prevention and therapy using ERbeta to validate biomarkers and develop future therapy and prevention strategies.

"Our preliminary studies, performed with the help of graduate students Karin Edvardsson, Trang Vu and Philip Jonsson, have yielded positive results, and we look forward to expanding upon our research with this this NCI grant," Williams said. "Our goal is to increase opportunities for improved colon cancer prevention and therapies."

This work also involves experts within related fields, including Jonna Frasor at the University of Illinois at Chicago, who studies estrogen and inflammation in the breast; Dr. Christopher Garrett at the University of Texas M.D. Anderson Cancer Center, a colon cancer clinician; Preethi Gunaratne, a bioinformatics researcher and professor in the UH College of Natural Sciences and Mathematics; and UH CNRCS Director Dr. Jan-ke Gustafsson, who discovered ERbeta in the mid-1990s.

The National Cancer Institute (NCI) is part of the National Institutes of Health (NIH), which is one of 11 agencies that compose the Department of Health and Human Services. The NCI, established under the National Cancer Institute Act of 1937, is the Federal Government's principal agency for cancer research and training.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related medicine news :

1. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
2. Genetic markers for testosterone and estrogen level regulation identified
3. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
4. Estrogen helps keep joint pain at bay after hysterectomy
5. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
6. Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
7. Estrogen fuels autoimmune liver damage
8. NuvaRing Lawsuits Move Forward, as Federal Judge Rules that Plaintiffs’ Experts May Testify on “Bursts” of Estrogen Allegedly Delivered by NuvaRing, Wright & Schulte LLC
9. Exercise-related changes in estrogen metabolism may lower breast cancer risk
10. Estrogen Levels Tied to Risk for Sudden Cardiac Death in Study
11. New Stool Test Might Aid in Early Detection of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Role of estrogen in colon cancer prevention, treatment studied at UH
(Date:10/13/2017)... LEXINGTON, Ky. (PRWEB) , ... October 13, 2017 , ... ... MD, MPH to become its next President and Chief Executive Officer, succeeding Dr. James ... and CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... Sept. 25, 2017   Montrium , an ... solutions, today—from the IQPC Trial Master Files & ... NL)—announced that EastHORN Clinical Services has selected ... and TMF management. EastHORN, a leading European contract ... to increase transparency to enable greater collaboration with ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
Breaking Medicine Technology: