Navigation Links
Rogue bacteria involved in both heart disease and infertility
Date:11/20/2007

producing enzymes.

Chlamydiae fight back, says Azenabor, His work shows that, as they are ingested, these two species of Chlamydia can manipulate the functions of protective cells like macrophages in creative ways.

Cholesterol connection

One of the keys lies in the macrophages cell walls, which store cholesterol and usually tightly control it.

But when its infected with C. pneumoniae, the microbe traffics cholesterol from the macrophage cell membrane to its own, causing a change in the macrophage that makes it rigid and unable to move.

The bacterium also disturbs the macrophages production of toxins in a process that transforms them into signaling molecules, which support functions that keep the bacterium alive.

C. pneumoniae really wants to hijack the cell functions for its own use, like a parasite would, he says. The macrophage, though, wants to kill Chlamydia, but its killing ability has been converted to signaling.

This is the reason the infection becomes chronic, Azenabor says. Because of signaling, everything else in the human cell is still fine except for the altered toxins, so the bacteria can reproduce in a short time.

As the macrophages become immobile, they accumulate in the blood vessel walls, setting the stage for atherosclerosis.

Infection and pregnancy

Armed with new information about how C. pneumoniae sabotages the immune response, Azenabor, who had also been studying the effects of estrogen on macrophages, turned his attention to another Chlamydia-related puzzle.

How is Chlamydia trachomatis, the species that causes a sexually transmitted disease, involved in the occurrence of spontaneous abortions or miscarriages?

He was immediately drawn to the protective cells in the placenta during early pregnancy the trophoblasts.

Its not for nothing that trophoblasts are the early cells, says Azenabor. They prevent any kind of infectio
'/>"/>

Contact: Anthony Azenabor
aazenabo@uwm.edu
414-229-5637
University of Wisconsin - Milwaukee  
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Bacteria See the Light
2. Antibacterial Soap Claims Just Dont Wash
3. New viruses to treat bacterial diseases -- My enemies enemy is my friend
4. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
5. Bacteria successful in cancer treatment
6. What gives us sunburn protects crayfish against bacteria
7. Appendix isnt useless at all: Its a safe house for bacteria
8. Early Bacterial Infection May Boost Asthma Risk
9. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
10. New peptide communication factor enabling bacteria to talk to each other discovered
11. New Study Reveals MRSA Bacteria Common Among Pigs and Farm Workers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rogue bacteria involved in both heart disease and infertility
(Date:5/5/2015)... Dr. Patricia George knows all too well ... and pulmonary hypertension specialist at the University of Pittsburgh ... when an initial idea entered her mind for Team ... audience at the 2010 PHA International Conference,” George recalled. ... were recalling their climb up Mt. Kilimanjaro and I ...
(Date:5/5/2015)... year, PolyU researchers garnered two Grand Prizes, two Special ... and four Silver Medals at the world-renowned event. The ... Prize and Gold Medal with the Congratulations of Jury:, ... Investigator: Dr Allan Chee-kooi CHAN, Institute of Textiles and ... the “mannequin” for many tasks involved in apparel design, ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 Okyanos, the ... Lifestyle Report today. The study was conducted to determine ... as osteoarthritis and sports-related injuries have had ... stiffness was the most prevalent symptom reported at 73%, ... as walking, standing and bending over. Over half of ...
(Date:5/5/2015)... 05, 2015 With Mother's Day, ... one of the country's leading organic vegetable brands, ... moms across the country. What to eat? There’s ... box or spend hours browsing Pinterest – Josie's ... http://www.josiesorganics.com/recipes . , The new recipes are ...
(Date:5/5/2015)... In the upbeat Moms Helping Moms video, real ... support each other. Parenting is a tough job, but ... so much easier. Mothers talk about how relating and ... and help them realize there’s no perfect parent; everyone is ... clearly dear friends share that it's just that, the friendship ...
Breaking Medicine News(10 mins):Health News:World PH Day: Team PHenomenal Hope Races to Spread the Word about Pulmonary Hypertension 2Health News:PolyU wins top prizes in Geneva’s Invention Expo 2Health News:PolyU wins top prizes in Geneva’s Invention Expo 3Health News:PolyU wins top prizes in Geneva’s Invention Expo 4Health News:PolyU wins top prizes in Geneva’s Invention Expo 5Health News:Okyanos Study Finds Orthopedic Patients Plagued with Pain 2Health News:Okyanos Study Finds Orthopedic Patients Plagued with Pain 3Health News:Josie's Organics Kicks Off Mother's Day, Graduation and Grilling Season with New, Easy-to-Follow, Convenient Recipes 2Health News:Josie's Organics Kicks Off Mother's Day, Graduation and Grilling Season with New, Easy-to-Follow, Convenient Recipes 3Health News:Josie's Organics Kicks Off Mother's Day, Graduation and Grilling Season with New, Easy-to-Follow, Convenient Recipes 4Health News:Just In Time For Mother’s Day, Healthy Birth Day Releases Video Titled “Moms Helping Moms” Encouraging Mothers To Band Together 2
... increasing at an alarming rate yet a superior, simpler, natural solution ... ... 2008 -- Purported "brain enhancement" drugs such as Ritalin, Modafinil, and ... States during the past decade according to the National Institute of ...
... raised more,than $2.2 million for cancer and related disease research ... "Help the Hutch," a portion of the live ... levels, brought in $1.2 million to,be directed toward immunotherapy, through ... The black-tie Gala took ...
... Network Services,LLC (MNS) announced today, that it has ... Inc. to become effective December 1, 2008.,Under the ... of skilled nursing,services to eligible health plan participants ... regionally in Illinois, Indiana, Kentucky and,Ohio. In ...
... for Dummies is an authoritative guide explaining the causes of ... , NEW YORK, Dec. 8 ... and Dr. William Rassman, have co-authored the first authoritative, but ... loss, its prevention, and their medical and hair transplant options. ...
... on a 1,230-foot-long wall,along Madison Ave., located just south ... World Record. The mural was among 60,beautification projects completed ... than 50 local community organizations during,Eli Lilly and Company,s ... Lilly and KIB ...
... 8 OECD,s latest survey of the United States, to ... the challenges facing the new administration amid a severe economic ... healthcare. The Washington D.C. launch will be held on Capitol ... and will offer first a panel discussion to present the ...
Cached Medicine News:Health News:Brain Boosting Drugs vs. Walking: Treadmill Desk Manufacturer Promotes Common Sense 2Health News:Brain Boosting Drugs vs. Walking: Treadmill Desk Manufacturer Promotes Common Sense 3Health News:33rd Annual Hutch Holiday Gala Raises Millions for Cancer Immunotherapy Research 2Health News:33rd Annual Hutch Holiday Gala Raises Millions for Cancer Immunotherapy Research 3Health News:Hair Transplant Surgeons Author Hair Loss for Dummies Book 2Health News:Hair Transplant Surgeons Author Hair Loss for Dummies Book 3Health News:Lilly Global Day of Service Receives National and Local Recognition 2Health News:Lilly Global Day of Service Receives National and Local Recognition 3Health News:OECD Economic Survey of the United States 2
(Date:5/5/2015)... May 5, 2015  Image Stream Medical, a leader ... with MedAssets, one of the largest group purchasing organizations, ... States.  Under terms of the three-year agreement, Image Stream,s ... will be made available to MedAssets members beginning on ... Image Stream Medical CEO Eddie Mitchell said, ...
(Date:5/5/2015)... 5, 2015  The Association of periOperative Registered Nurses ... The Preoperative Stop and Go Sign designed ... Mauricio Gonzalez , M.D., anesthesia providers with Anaesthesia ... Go Sign product is distributed by the Plexus ... and is in compliance with the AORN Safe Surgery ...
(Date:5/5/2015)... CITY, Calif. , May 5, 2015  Abaxis, Inc. ... blood analysis systems, announced today that Clint Severson , ... of America Merrill Lynch 2015 Health Care Conference on Tuesday, ... be held at the Encore at the Wynn in ... Inc. is a worldwide developer, manufacturer and marketer of portable ...
Breaking Medicine Technology:Image Stream Medical Announces Agreement with MedAssets 2The Preoperative Stop and Go Sign Interactive Checklist Awarded AORN Seal of Recognition 2The Preoperative Stop and Go Sign Interactive Checklist Awarded AORN Seal of Recognition 3
... Guidant's fourth generation access device - XPOSE ... the heart. The XPOSE 4 Device is ... off-pump bypass surgery and to easily position ... Designed for both apical and non-apical placement ...
... is an intuitive, all-in-one endoscopic vessel ... the scarring and risk of infection ... an enhanced, ergonomic handle design with ... this new device is intended to ...
... System includes three major components: Blood pump, ... Portable Driver. This system provides partial or ... with conventional therapy, is unable to maintain ... accomplish support, blood flows from the natural ...
... Fibrin Sealant has been shown to be ... Containing uniform, reproducible concentrations of fibrinogen and ... final stage of the coagulation cascade to ... firmly adheres to connective tissue like a ...
Medicine Products: