Navigation Links
Roadkill study could speed detection of kidney cancer
Date:1/27/2009

Large-scale data mining of gene networks in fruit flies has led researchers to a sensitive and specific diagnostic biomarker for human renal cell carcinoma, the most common type of kidney cancer. In the journal Science, published early online January 22, a team based at the University of Chicago shows that the biomarker known as SPOP is produced by 99 percent of clear cell renal cell carcinomas but not by normal kidney tissue.

Physicians could use SPOP levels to confirm or rule out a diagnosis of renal cell carcinoma (RCC). It could also help them determine the original source of cancers that had spread to other organs from an unknown primary tumor.

"This could serve as a diagnostic tool, lead us to new drug targets and potentially help us detect kidney cancers sooner," said study-director Kevin White, PhD, professor of human genetics, and ecology and evolution, and director of the Institute for Genetics and Systems Biology at the University of Chicago. "It also confirms our strategy of using genomics and systems-level analysis of model organisms such as fruit flies to identify factors that play crucial roles in human disease."

The study began with the fly genome. White and colleagues, who study gene regulationhow genes or entire networks of genes get turned on of offwanted to measure the downstream effects of two key genes, known as Eve and Ftz, that control early steps in the development of flies, beginning just after the eggs are laid.

Because Eve and Ftz regulate the activity of other genes, and many of those genes control the activity of additional genes, both had a large impact. Eve influences the expression of 1,074 different genes and Ftx impacts 1,310 genes.

When they narrowed their search to genes directly impacted, the total fell to 235 genes. About 20 percent of those target genes regulate transcription, the activation of other genes, and 40 percent controlled developmental processes.

About 150 of those target genes have human equivalents. When the researchers ranked those 150 genes according to their impact in flies, the top candidate was a gene known as CG9924, or Roadkill, the central player in a major hub of networked genes and a crucial component in the development of the nervous system. SPOP, the human equivalent, is about 80 percent identical to Roadkill.

Looking closer, they determined that SPOP appeared to play a role not just in development but also in human cancers. It interacts with cell signaling pathwaysJNK and RASthat frequently go awry in multiple human cancers.

At this point, the researchers shifted their focus from fly genetics to human cancer. When they screened hundreds of tissue samples from 18 different tumor types, acquired from patients having surgery, they found that 85 percent of renal cell carcinomas produced high amounts of SPOP, while normal kidney tissue was uniformly negative.

When they looked at 300 renal cell cancer samples, 77 percent were positive for SPOP. All normal kidney samples were negative.

About 75 percent of all renal cell cancers are clear cell RCC. The researchers found that 99 percent of the clear cell RCC samples showed evidence of elevated SPOP. The SPOP test even revealed that a few tumors had originally been misdiagnosed as clear cell RCC. Those turned out to be other types of kidney cancer when examined more closely by pathologists.

"These results indicate that SPOP is a highly sensitive and specific diagnostic biomarker for clear cell RCC," the authors conclude, "and can help distinguish histological subtypes of RCC."

It could also be used to help identify the primary tumor in metastatic cancers, important in treatment decisions.


'/>"/>

Contact: John Easton
John.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert  

Related medicine news :

1. Top hospitals have 27 percent lower mortality: Annual HealthGrades study
2. New study: Short coverage lapses limit childrens access to health care services
3. Study Finds High-Fructose Corn Syrup Contains Mercury
4. New findings on old kidneys could enhance transplants, Stanford study shows
5. Cell phones dangerous for child pedestrians, UAB study finds
6. New Study: Higher DHA Levels Improve Neurodevelopmental Outcomes in Premature Girls
7. Study examines risk factors for cancer in unaffected breast of breast cancer patients
8. New study aims to reduce risk of childhood leukemia
9. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
10. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
11. UCI behind worlds first embryonic stem cell study in humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Roadkill study could speed detection of kidney cancer
(Date:2/14/2016)... ... February 14, 2016 , ... In honor of ... Nurses (AAHFN) is promoting healthier living with heart failure by providing educational materials ... Living with Heart Failure will kick-off February 14 and includes tips on keeping ...
(Date:2/13/2016)... ... February 13, 2016 , ... Many individuals looking to lead a healthy lifestyle ... reasons. IsoPasta by Isolator Fitness has delved into this niche allowing those giving ... high-carb repercussions. IsoPasta has 30 grams of protein and only 7 grams of ...
(Date:2/13/2016)... ... ... an Au Pair comes all the way around the world to provide child ... are often worried things won’t go well. More often than not, however, they find out ... the Year winner’s all commented how their Au Pairs have become a part of the ...
(Date:2/12/2016)... ... 2016 , ... The law firm of Morrow, Morrow, Ryan & Bassett is ... these scholarships is to encourage applicants to pursue a degree in their field of ... parishes. , “We have available jobs in St. Landry and Evangeline Parishes that ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical ... in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the ... products in action, learn more about their chosen field and network with their colleagues. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , 12 februari 2016 ... een toonaangevende leverancier van productie en ontwikkeling ... industrieën, kondigt vandaag een uitbreiding aan van ... haar locatie in Charleston, SC ... geleid tot meerdere recente investeringen. ...
(Date:2/12/2016)... , Ungarn, February 12, 2016 ... das sich auf den ungedeckten medizinischen Bedarf ... positive Ergebnisse seines klinischen Forschungsprogramms bekannt. Das ... beschäftigt, ergab Verbesserungen ihrer respiratorischen Funktionen und ... ltd , ein Medizintechnikunternehmen, das sich auf ...
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 ... - Companion Diagnostics in Personalized Medicine and Cancer ... Markets. - High-Growth Diagnostic Testing Markets. - ... Cancer Testing. - Molecular Diagnostics in Genetic Testing. ... - Molecular Diagnostics Markets. - Over-the-Counter Diagnostic Products ...
Breaking Medicine Technology: