Navigation Links
Road mapping could be key to curing TB
Date:2/5/2010

The complex chain of metabolic events in bacteria that lead to fatal diseases such as tuberculosis (TB) may be better understood using mathematical models, according to an article published in the February issue of Microbiology Today.

Scientists at the University of Surrey are using this new 'systems biology' approach to try and understand the metabolic changes that occur in the bacterium Mycobacterium tuberculosis which allow it to survive dormant in host cells for decades. A more complete knowledge of these changes could allow new drugs to be developed against such 'persistent' bacterial cells, which in turn would revolutionise TB control.

The classic approach to understanding biological functions in mammals and microbes alike has been based on the assumption that a single gene is primarily responsible for a single function - which can be inhibited by simply blocking the gene. This gene-centric approach has led to huge breakthroughs in scientific understanding of cellular processes, but is less useful for understanding complex functions such as metabolism. In this case, blocking a single gene does not impair function because other genes in the network are able to compensate to maintain that function. This suggests it may be more realistic to assume that many genes are likely to have minor roles in any number of functional pathways.

Professor Johnjoe McFadden who works on TB at the University of Surrey likens metabolic pathways in cells to Britain's road network. "For example, we may identify a particular road, say the A45, that takes goods from Birmingham to Coventry and call it the BtoC road - or BtoC gene," he said. "Blocking the A45 might be expected to prevent goods from Birmingham reaching Coventry. But of course it doesn't because there are lots of other ways for the goods to get through. In truth, the 'road' (or gene) from BtoC isn't just the A45, but includes all those other routes."

A good starting point to study functional pathways is a mathematical model of the cell that takes into account the system properties of the whole network, rather than focussing on key control points. Professor McFadden explains how microbes are well suited to this systems-level approach. "Microbes have fewer genes to interact with each other making computational modelling simpler. Also, unlike multicellular organisms, microbes are able to precisely control their growth. This 'steady-state growth' is an important assumption that mathematical models are based on."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related medicine news :

1. Language centers revealed, brain surgery refined with new mapping
2. Mapping tool allows emergency management personnel to visually track resources
3. Mapping of prostate cancer genes opens the door to new treatments
4. Texas Cardiac Arrhythmia Institute at St. Davids Medical Center First in the Nation to Use a New Generation of Medical Robots for Complex Electrophysiology Mapping Procedures
5. First-Ever Mapping of Cancer Patients Genome
6. Deep brain mapping to isolate evidence of Gulf War syndrome
7. Global Mapping Tool Demonstrates Medical Donation Impact
8. UH research team developing new noninvasive brain-mapping technology
9. Elsevier and Brain Mapping Foundation co-host 6th Annual World Congress of IBMISPS
10. Elekta Chosen to Deliver Sophisticated Brain Mapping Technology to the Mind Research Network
11. Mapping gene expression with Gene Expression Atlas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... a2z, Inc. is ... and Canadian Association for Enterostomal Therapy (CAET) will be utilizing powerful and innovative ... to attendees and exhibitors for the 2016 WOCN Society & CAET Joint Conference—which ...
(Date:5/4/2016)... ... May 04, 2016 , ... Washington Wellness Center today ... central New Jersey residents. What started out as an idea to provide a ... integrated approach to healthcare. , Developed by Dr. David Swanekamp, Chiropractic Physician , ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... is transforming breastfeeding for nursing mothers. The company’s patented technology, The Smart Breastfeeding ... Today, the company announced that the technology is now available for purchase at ...
(Date:5/4/2016)... ... ... Natalie Jill is a well respected lifestyle mentor and fitness ... of her new book: Natalie Jill’s 7 Day Jump Start: Unprocess Your Diet . ... a new healthy lifestyle featuring simple recipes using MitoXcell’s raw cacao formula. , ...
(Date:5/4/2016)... ... ... Advanced Spine & Sport Medical Rehabilitation Center, which is renowned for its ... seminar on stem cell injections. The seminar is scheduled for Wednesday, May 18, from ... Suite 110, Ventura, CA. There are only 10 seats available. , “The purpose ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK , ... today announced Food and Drug Administration (FDA) approval ... that provides heart failure patients with access to ... also have remote monitoring with daily automatic transmission ... heart rate in response to physiological demands. ...
(Date:5/3/2016)... Pharmaceutical giant Johnson & Johnson ... woman who says its talc-based powder products caused ovarian ... $5 million in compensatory damages and $50 million ... ) , This is the second ... February, the same court awarded $72 million to the ...
(Date:5/3/2016)... Utah , May 3, 2016  Forté Elements, LLC (Forté) is excited to ... nutritional products that address the nutritional needs of recovery for a variety of clinical ... products. Photo - http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
Breaking Medicine Technology: