Navigation Links
Rituximab maintenance therapy improves survival in patients with relapsed follicular lymphoma
Date:2/10/2009

Patients with relapsed or refractory follicular lymphoma who continue on maintenance rituximab therapy after chemotherapy have better overall survival than patients who do not receive this treatment, according to a meta-analysis of randomized trials in the February 10 online issue of the Journal of the National Cancer Institute.

Most patients with follicular lymphoma respond to initial therapy but many experience disease relapse. Previous trials have showed that rituximab plus chemotherapy improves overall survival in these patients compared with chemotherapy alone. However, it has not been clear if continuing rituximab treatment beyond the completion of chemotherapy further prolongs overall survival.

To determine the impact of maintenance rituximab on overall survival, Liat Vidal, M.D., of the Rabin Medical Center in Petah-Tikva, Israel, and colleagues pooled data from five randomized trials that compared maintenance therapy with no maintenance therapy. Overall survival data were available for 985 patients.

Rituximab maintenance therapy was associated with a 40% improvement in overall survival relative to observation or retreatment with rituximab at relapse. The improvement in overall survival was statistically significant for patients with relapsed or refractory lymphoma, but not for previously untreated patients. Patients treated with rituximab maintenance therapy, however, had nearly twice the rate of infection-related adverse events as patients who did not have prolonged rituximab therapy.

"Our results suggest that rituximab maintenance therapy for up to 2 years, either as four weekly infusions every 6 months or as a single infusion every 2 3 months, should be added to standard therapy of patients with relapsed or refractory follicular lymphoma after successful induction treatment," the authors write. "The higher rate of infections with rituximab therapy should be taken into consideration when making treatment decisions."


'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Turning down gene expression promotes nerve cell maintenance
2. Jiffy Lube Service Centers Kick-off Year Two Of Maintenance Partners For Life Campaign To Benefit American Heart Association
3. FDA Approves AstraZenecas Seroquel(R) for Maintenance Treatment in Bipolar Disorder
4. FDA Approves Strattera(R) for Maintenance of ADHD in Children and Adolescents
5. Federation of State Medical Boards Takes Interim Steps Toward Maintenance of Licensure Model Policy
6. Schiff(R) Introduces New Supplement Products for Intestinal Health and Beauty Maintenance
7. Jiffy Lube(R) Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign
8. FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11
9. Maintenance Software Company Bucks Trend, Offers Unlimited No-Charge Product Tech Support
10. Manufacturing Organizations Identify Efficiencies in Maintenance Functions
11. VA Hospital Draws Curtain on Innovation That Could Help Reduce Spiraling Cost of Hospital Maintenance Nationwide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... February 23, 2017 , ... Healthcare Research & Analytics® (HRA®) ... fight against cancer, has produced a seminal study that asked cancer survivors and ... findings in a webinar, Defining Compassionate Care Through the Voices of Patients and ...
(Date:2/23/2017)... ... 2017 , ... Top cosmetic and periodontal dentist Dr. Mahnaz Rashti ... Indiegogo campaign . Individuals are now able to contribute to the local initiative, ... as a participating patient or through an Indiegogo donation. The entirety of proceeds will ...
(Date:2/23/2017)... , ... February 23, 2017 , ... Carlos Gutierrez ... He has also continued to spiritually evolve, which is the purpose of everyone in ... Our Spiritual Truths ” (published by Balboa Press) attempts to guide readers to expand ...
(Date:2/22/2017)... Tampa, Fla. (PRWEB) , ... February 22, 2017 ... ... the field of regenerative medicine in recent years. The technology is so cutting ... sanction regulations on the protocol for stem cell procedures. However, successful patient outcomes ...
(Date:2/22/2017)... ... February 22, 2017 , ... South Bend’s Lunkerville, the ... once again feature Heroes On The Water (HOW), a non-profit organization dedicated to helping ... episode has series host ‘Mike D’ traveling to Lake Denmark, New Jersey, to fish ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... -- Genesis Healthcare Services has merged with Hospice Cloud, a ... Bill Monast , President and CEO of Hospice Cloud ... , executives with Home Health Depot, Inc., the parent ... This acquisition helps Hospice Cloud maintain its position as ... equipment (DME) solutions for the hospice industry. Nathan ...
(Date:2/23/2017)... , Feb. 23, 2017  Cogentix Medical, Inc. ... and markets innovative proprietary products for the urology market, ... fiscal year ended December 31, 2016 before the market ... The Company will host a conference call and webcast ... Thursday, March 9, 2017 at 11:00 a.m. Eastern Time ...
(Date:2/23/2017)... REDWOOD CITY, Calif., Feb. 23, 2017 Nevro Corp. ... innovative evidence-based solutions for the treatment of chronic pain, today ... ended December 31, 2016. 2016 Accomplishment & ... the full year 2016, an increase of 228% as reported, ... million for 2016, an increase of 612% over the prior ...
Breaking Medicine Technology: