Navigation Links
Risk of death increases in IBD patients with hospital-acquired infections
Date:11/30/2010

Death and length of stay are increased among hospitalized inflammatory bowel disease (IBD) patients who develop hospital-acquired infections, according to a study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. Also, health-care-associated and hospital-acquired infections are most frequent in patients with severe liver disease, according to an additional study published in the journal.

"Our data demonstrate that inflammatory bowel disease patients with hospital-acquired infections are at increased risk of inpatient mortality and experience a significantly longer length of stay in the hospital," said Raffi Karagozian, MD, of Brigham and Women's Hospital and lead author of this study. "Though hospital-acquired infections are low-frequency events, increased vigilance to avoid these infections among patients could improve outcomes."

Among the 2,324 patients with IBD examined in this study, there were 20 deaths and 22 reported cases of hospital-acquired infections (these types of infections occur in approximately 1 percent of hospitalized cases with IBD). The mortality from these infections among IBD patients was 13.6 percent, compared with 0.9 percent among controls.

The median length of stay for patients with IBD and hospital-acquired infections was 22 days, versus six days for controls. Of these 22 cases, 15 were urinary tract infections, five were blood stream infections and two were from multiple sources.

Hospital-acquired infections affect approximately two million patients each year in the U.S., resulting in 90,000 deaths with an estimated $4.5 to $5.7 billion per year towards patient care costs. Between 5 percent and 10 percent of patients admitted to acute care hospitals acquire one or more infections, and the risks have steadily increased during recent decades.

In a second study, researchers found that the large majority of total bacterial infections (54) in hospitalized cirrhotic patients were health-care associated (22) or hospital acquired (20). Bacterial resistance was also more frequent among patients with either of these infections. These infectious episodes worsened liver function in 62 percent of patients. In addition to the severity of the liver disease, protein malnutrition was an important risk factor for the development of infections in liver cirrhosis.

Cirrhosis occurs when the liver is permanently scarred or injured by chronic conditions and diseases. The scar tissue that forms in cirrhosis harms the structure of the liver, blocking the flow of blood through the organ.

"It is worth noting that in-hospital death was higher in cirrhotic patients with health-care-associated infections compared with those not infected. In addition, infected cirrhotic patients showed worse long-term survival (compared to those without infections) even if they were discharged from the hospital," said Manuela Merli, MD, of Sapienza University of Rome and lead author of this study. "Bacterial infections are in fact a frequent and serious burden among patients with cirrhosis because they can further deteriorate liver function."

Cases of infection are reported in 40 percent of hospitalized cirrhotic patients. As infections worsen, liver function deteriorates and mortality increases. Therefore, cirrhotic patients should be closely monitored for infections.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Most maternal deaths in sub-Saharan Africa could be avoided
3. Cleveland Medical Malpractice Attorney Obtains Settlement in Wrongful Death Case
4. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
5. Hormone thought to slow aging associated with increased risk of cancer death
6. Some Parents Consider Hastening a Sick Childs Death
7. New tool to predict early death or hospital readmission
8. Death After Discharge Rates Higher in Elderly ICU Patients
9. High Hormone Level Linked to Cancer Death in Older Men
10. As Temperatures Rise, So Do Cocaine Deaths
11. PSA Test Reduces Prostate Cancer Deaths by 40%
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: