Navigation Links
Risk of cancer
Date:6/29/2009

Finnish Academy Professors Lauri Aaltonen and Jussi Taipale have identified and described a mechanism whereby a single-base change in the human genome increases the risk of colorectal cancer.

The focus in this study was on a common single-base variant occurring in chromosome 8, which in itself causes only a slightly increased risk of cancer. However, the risk allele is carried by 75% of people of European origin and by almost 100% of African populations.

The high frequency of the gene variant makes it a very common cause of cancer at the population level. At the individual level, however, the variant does not cause significant disease predisposition because that can often be considerably reduced by lifestyle changes. Colorectal cancer is the third most common cancer worldwide and a major cause of cancer mortality.

Mutation mechanisms activate pathways regulating cancer

The variant that increases the risk of colorectal cancer was found to be located in a regulatory region, where it changes the function of a key regulatory element important for the development of colorectal cancer. The scientists showed that the risk allele strengthens the binding of a regulatory factor in cancer cells, which activates pathways that are central to the development of cancer. The impacts of this altered genetic regulation on cell division are probably mediated via the MYC cancer gene, which is one of the best known accelerator genes in cancer.

Single-base changes are the most common type of variation found in the human genome. Genome-wide studies of interindividual differences in common variants can be studied using DNA chip technology, which has greatly facilitated efforts to understand the genetic basis of multifactorial diseases. To date, scientists have identified more than 400 variants in the human genome that are associated with an increased risk of common diseases, such as cancer, diabetes and cardiovascular diseases.

Multidisciplinary research

The findings of this research lend support to the theory that human disease susceptibility is explained in part by differences in regulatory regions of the genome, and in gene expression. A closer understanding of the biological mechanisms involved will help to clarify the aetiology of colorectal cancer and pave the way to more effective cancer prevention. Apart from hereditary tumor predisposition, another area of major strength for Finnish research is gene regulation. It was hardly surprising therefore that Aaltonen's and Taipale's research teams found each other so easily. The research project supervised by Aaltonen and Taipale involved molecular biologists, medical doctors and data processing researchers from Finland and the UK. For instance, the project made use of the EEL software developed by Professor Esko Ukkonen and his team at the CoE for Algorithmic Data Analysis.


'/>"/>

Contact: Academy Professor Lauri Aaltonen
lauri.aaltonen@helsinki.fi
358-505-846-763
Academy of Finland
Source:Eurekalert

Related medicine news :

1. Statement from IDF on studies suggesting possible link between insulin glargine and cancer
2. Second gene linked to familial testicular cancer
3. Look Good...Feel Better and OPI Celebrate 20 Years of Helping Women Cope With Cancer
4. Launch of Targeted Agents and Increased Use of Maintenance Therapy Will Drive the Non-Small-Cell Lung Cancer Drug Market to Nearly Triple to Almost $10 Billion in 2018
5. Chemical Nose May Sniff Out Cancer Earlier
6. Dietary fat linked to pancreatic cancer
7. Breast Cancer Numbers Dip Most in Wealthy, Urban Areas
8. Eating Animal Fat May Lead to Pancreatic Cancer
9. Positive CHMP Opinion for JAVLOR(R) in Metastatic Treatment of Bladder Cancer After Failure of a Prior Platinum-Containing Regimen
10. Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer
11. Minor League Baseball Teams Aim to Strike Out Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... The Dentists ... it has signed a letter of intent with Moda to acquire ... Company (NORDIC). , Started by dentists 36 years ago, TDIC focuses exclusively on ...
(Date:4/28/2016)... ... April 28, 2016 , ... Sanford Health’s work ... A group of researchers and leaders from Sanford Health were selected to participate ... Its Cultural Impact ” and receive the 2016 Pontifical Key Innovation Award at ...
(Date:4/28/2016)... ... April 28, 2016 , ... ProText Layouts is a set ... Pro X . With ProText Layouts, video editors can create an energetic typography ... length and scale of texts. Creating text-based videos have never been easier. , ...
(Date:4/28/2016)... ... April 28, 2016 , ... La Sirena Foods provides ... in Central America and is looking to grow their market share in the USA. ... exceptional brand as La Sirena Foods and indirectly with Otis McAllister ...
(Date:4/28/2016)... California (PRWEB) , ... April 28, 2016 , ... ... and accessories, is proud to partner with AquaShieldUSA, the country's oldest waterproof ... patient, clinic and medical supply stores, the largest selection of daily, night, weatherproof ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...   Click here for supplemental information regarding ... the nation,s largest independent specialty pharmacy, announced today ... acquire Valley Campus Pharmacy, Inc., doing business as ... pharmacy that provides individualized patient care, based in ... 2015, TNH generated approximately $400 million in revenue. ...
(Date:4/28/2016)... 2016  While Abbott,s announced purchase of St. ... repair and stent business, healthcare research firm Kalorama ... firmly into patient monitoring.  Kalorama said that patient ... areas, with double-digit growth expected the next 5 ... Remote Patient Monitoring . Abbott Laboratories agreed ...
(Date:4/28/2016)... 28, 2016 Research and Markets ... Surgery Products Market 2016-2020" report to their offering. ... The global plastic surgery products market is ... the period 2016-2020. , ,The growing adoption of laser ... growth of the market. Lasers are used to treat ...
Breaking Medicine Technology: