Navigation Links
Risk of HIV, West Nile Virus, E Coli Transmission May be Reduced Through Improved Blood Screening Methods
Date:12/28/2007

Blood donor question-and-answer style strengthened with technological advancements

CHICAGO, Dec. 28 /PRNewswire-USNewswire/ -- The blood transfusion community should consider pathogen inactivation methods as an alternative way to assure the safety and availability of the nation's blood supply, a pathologist wrote in the December issue of the American Journal of Clinical Pathology (AJCP).

"For more than 20 years we have used a method that includes asking potential donors a series of questions to determine whether or not we should use their blood," said Jeffrey McCullough, MD, FASCP, professor of laboratory medicine and pathology at the University of Minnesota.

"But now there are proactive methods available that allow us to use blood that we may not have used if we didn't get a certain answer."

His article, "Pathogen Inactivation: A New Paradigm for Preventing Transfusion-Transmitted Infections," reviews the shortcomings of the current paradigm of blood banking and what is on the horizon with newer pathogen inactivating methods.

The riboflavin method, which works by damaging DNA to eliminate its capability of regenerating, is effective for inactivating intracellular and extracellular HIV, West Nile virus, Staphylococcus, Escherichia coli and several others.

In the amotosalen method, cross-links are created, preventing harmful DNA or RNA from separating and replicating. Amotosalen also inhibits the synthesis of certain proteins, reducing the likelihood of transfusion reactions. Amotosalen treated platelets are now widely used in Europe and the riboflavin method was recently approved there. Amotosalen treated platelets are awaiting action by the U.S. Food and Drug Administration.

Finally, the RBC method cross links DNA and RNA, effectively targeting nucleic acids in pathogens. Further developments are needed to begin a new Phase 3 trial of this method in the United States.

According to the American Red Cross, the safety of the blood supply is maintained by screening potential donors for a variety of risks, including recent infections, recent antibiotic intake, bleeding conditions, fever, sexual practices, and more. McCullough acknowledged that the screening approach, followed by selective testing, has resulted in a very low risk of transfusion-transmitted infection. The chance of contracting HIV through blood transfusion, for instance, is 1 in 1.5 million.

However, said McCullough, if a person has traveled outside of the United States in the past 12 months, they may be prohibited from donating blood. Pathogen inactivation methods, now widely used in Europe, offer several ways to test and treat blood for use.

"We could potentially be turning away a lot of usable blood with the question method," he said. "Someone very well may have traveled, but didn't contract anything."

While the cost of pathogen-inactivation may be an issue, McCullough sees the payoff through elimination of countless hours developing strategies to deal with new agents and the elimination of costs associated with caring for patients with transmitted diseases.

Founded in 1922, the American Society for Clinical Pathology is a professional society with nearly 130,000 member pathologists and laboratory professionals. Based in Chicago, the ASCP provides excellence in education, certification, and advocacy on behalf of patients, pathologists, and laboratory professionals.


'/>"/>
SOURCE American Society for Clinical Pathology
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Methamphetamine study suggests increased risk for HIV transmission
2. Unstable housing status increases the risk of HIV transmission
3. New Case Study Details How an Illinois Hospital Created a Safe Lifting Team that Dramatically Reduced Injuries, Increased Staff Satisfaction
4. Giving emergency nurses aromatherapy massages with music dramatically reduced stress levels
5. Giving emergency nurses aromatherapy massages with music dramatically reduced stress levels
6. Can racial health disparities be effectively reduced?
7. Fetal cell transplant could be a hidden link between childbirth and reduced risk of breast cancer
8. Vitamin A derivative associated with reduced growth in some lung cells
9. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
10. HIV drug resistance risk in mothers reduced by combination of common drugs
11. Nicotine-Reduced Cigarettes Could Boost Quitting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... 29, 2016 , ... Melanoma is the deadliest type of skin cancer. Although only about 1 ... skin cancer deaths. More than 10,000 people are expected to die of melanoma this year. ... is the one of the most commonly diagnosed cancers in young women. A recent breakthrough ...
(Date:4/29/2016)... ... April 29, 2016 , ... Reltok Nasal Products proudly announces that Boston ... and neck/ear, nose and throat specialty, has added the KOTLER NASAL AIRWAY™ to its ... is a newly patented safety device secured by nasal surgeons onto the floor ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... Dairy Products, Inc. in an upcoming episode, airing third quarter 2016 via Discovery ... churning cream into butter, Grassland Dairy Products, located in Greenwood, Wisconsin applies product ...
(Date:4/29/2016)... ... April 29, 2016 , ... The infertility specialists at HRC Fertility/Orange County ... Dr. Daniel A. Potter -- are proud of the recent release of their 2014 ... April, SART published the latest verified data for 375 U.S. member clinics. ...
(Date:4/29/2016)... ... 29, 2016 , ... International Dehydrated Foods, Inc. (IDF™) will attend and sponsor ... the Doubletree by Hilton Hotel in Oak Brook, Illinois. The two-day event is the ... protein ingredients. , At the seminar, IDF™ will offer samples of its Savory ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016 ... Financier Sanofi, leader mondial ... ses résultats pour le premier trimestre ... Jérôme Contamine, commente les résultats du ... perspectives pour le reste de l,année. ...
(Date:4/29/2016)... , April 29, 2016 Automation ... science laboratory due to the growing demands for productivity ... technology, contemporary automated systems are already adept of a ... slow, tedious and manual labor. Instrumentation continues to evolve, ... even conceivable just a few years ago. Originally used ...
(Date:4/28/2016)... April 28, 2016  While Abbott,s announced purchase ... company,s valve repair and stent business, healthcare research ... Abbott more firmly into patient monitoring.  Kalorama said ... growing device areas, with double-digit growth expected the ... Advanced Remote Patient Monitoring . Abbott ...
Breaking Medicine Technology: