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Risk factors for CCSVI are similar to risk factors for developing MS, UB study shows
Date:11/30/2011

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"Our finding that a risk factor that is highly significant for MS Epstein-Barr virus, indicated by a history of infectious mononucleosis is strongly associated with CCSVI, is important," says Zivadinov.

"This is the first time a connection has been found between Epstein-Barr virus and CCSVI.

"We know that Epstein-Barr virus is associated with an increased risk for MS," he explains. "We also know that having mononucleosis when you are young increases the MS risk several-fold. So our finding that Epstein-Barr virus is also correlated with CCSVI is a novel finding that must be explored in future studies."

In addition, individuals with heart disease -- which is not a known MS risk factor -- were 2.7 times more likely to have CCSVI, and those with heart murmurs, in particular, were 4.9 times more likely to have CCSVI. Zivadinov added that the study's finding of a weak, protective effect from the use of dietary supplements was also noted and has to be further explored.

The UB team cautions that the study was preliminary and that these findings must be expanded upon and confirmed in further studies. The volunteer subjects were all part of the prospective Combined Transcranial and Extracranial Venous Doppler Evaluation study at UB. They were either independent individuals, or spouses or relatives of MS patients.

The controls were purposely selected from different sources of recruitment, Zivadinov explains.

"Spouses had no genetic similarity but may have shared environmental risk factors with MS patients, while relatives of MS patients had shared both genetic and environmental background," he says. "However, no differences in risk factors or frequency of CCSVI were found according to the various sources of recruitment."

All volunteers were screened for medical histories and underwent physical exams and Doppler sonography examinations of the neck; they also responded to an extensive environmental questionnaire. Individuals
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Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert

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