CCSVI refers to impaired blood flow from the central nervous system to the periphery. It has been hypothesized that this narrowing of veins restricts blood flow from the brain, altering brain drainage, and may contribute to brain tissue injury that is associated with MS.
Yet, while CCSVI has generated intense interest among MS patients worldwide, and while independent scientific studies, including one of the largest to date being conducted by Zivadinov and UB colleagues, have suggested an association with MS, none have found conclusively that the condition is associated with MS.
For this reason, the UB team decided that it was critical to proceed with this prospective study to determine the risk factors for CCSVI in individuals without neurological disease.
The study found that CCSVI risk factors occurred more frequently in 1) those with a history of mononucleosis, i.e. infected with Epstein-Barr virus; 2) those with irritable bowel syndrome; 3) those who smoke or have a history of smoking.
"All three are confirmed risk factors for MS," said Bianca Weinstock-Guttman, MD, second author on the study and professor of neurology at UB. According to the results, individuals with CCSVI were 2.7 times more likely than individuals without CCSVI to have infectious mononucleosis, 3.9 times more likely to have irritable bowel syndrome and 1.98 times more likely to have a history of smokin
|Contact: Ellen Goldbaum|
University at Buffalo