Navigation Links
Right warfarin dose determined by 3 genes
Date:3/20/2009

Researchers at Uppsala University, together with colleagues at the Karolinska Institute and the Sanger Institute, have now found all the genes the determine the dosage of the blood-thinning drug warfarin. The findings are published in the scientific journal PLoS Genetics.

"We have previously studied selected genes that can affect warfarin treatment. Now that we have gone in and scanned the entire genome, we see that the two most important genes are among those we previously singled out," says Mia Wadelius, a researcher at Uppsala University, and one of the scientists behind the study.

She also says that this is the first truly large warfarin study in which all genes were reviewed at the same time. More than 1,000 warfarin patients and roughly 370,000 gene variants, covering the entire human genome, were studied.

"The adequate warfarin dosage for a patient is determined by three genes: VKORC1, CYP2C9, and CYP4F2. This is a step forward for a large group of patients, because it will be easier to determine the dosage, and the treatment will be less risky," says Mia Wadelius.

Patients vary in their sensitivity to warfarin, which makes treatment initially a risky balancing act between bleeding and blood clots. Mia Wadelius says that the variation is great among patients, sometimes up to a difference of twenty times. But now that researchers have managed to identify which genes underlie this variation, it will be possible to predict different patients' needs for warfarin more precisely, rendering treatment safer. The next step is to look for markers for bleeding.

"We will continue to look for genetic variants that influence the risk of bleeding, which can be a reaction to warfarin treatment, though a rare one. The findings of the Swedish study will be combined with those from a British study in order to attain a sufficiently robust analysis of risks of bleeding," says Mia Wadelius.


'/>"/>

Contact: Mia Wadelius
mia.wadelius@medsci.uu.se
46-018-611-4945
Uppsala University
Source:Eurekalert

Page: 1

Related medicine news :

1. Stressed-Out Moms Carry Babies on the Right
2. Bright tumors, dim prospects
3. Quality Innovators to Network in Atlanta Sept. 19-21: Learn from Those Who Got It Right
4. Right breakfast bread keeps blood sugar in check all day
5. Stille and Enova Form Strategic Partnership to Introduce Worlds Brightest LED Cordless Surgical Headlights Into Europe and Japan
6. Experts Agree. Ohios Technology Investment Future Looks Bright
7. L.A. Playwright Creates an Enormous Wave with His New Book, Touch the Ocean
8. Civil Rights and Medical Leaders Call for Social Justice in Health Care
9. Flynn Pharma Acquires Rights From Pacira Pharmaceuticals to DepoDur(R), the Only Extended-Release Epidural Opioid for Post-Operative Pain, in Europe
10. New Report Says Health Courts Bureaucracies Offer Big Financial Burdens and Loss of Patient Rights
11. Federal Trade Commission Attempts To Suppress Best-Selling Authors First Amendment Rights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Virginia (PRWEB) July 11, 2014 ASHBURN PSYCHOLOGICAL ... took effect, which allows individuals with an intellectual disability or ... of their licenses and ID cards to alert law enforcement ... a condition. The idea was inspired by a central ... in protecting her 9 year old autistic son, JP. ...
(Date:7/10/2014)... More than 200 experts on aggression, who research ... will attend the 21st World Meeting of the ... the Loews Atlanta Hotel, July 15-19. , Georgia ... which is held every other year on alternating continents. ... scholars from more than 20 different countries, which will ...
(Date:7/10/2014)... New York, US (PRWEB) July 10, 2014 ... . , Merrill DataSite recently streamed the live webinar ... featuring a discussion from a group of several M&A ... are seeing in the broader energy transaction marketplace. These ... hot and how the deal market in this sector ...
(Date:7/10/2014)... 10, 2014 A Forever Recovery ... gets clients off to a great start and gives ... in, has launched a new Eating Disorders section of ... section highlights:, , Different types of ... of Mental Disorders (DSM-IV), including anorexia nervosa, bulimia nervosa, ...
(Date:7/10/2014)... 2014 (HealthDay News) -- Nature, not nurture, may play ... chimpanzees, a new study finds. "As is the ... cognitive [thinking] abilities in chimpanzees," William Hopkins of the ... a news release from the journal Current Biology ... the evolution of intelligence in humans, Hopkins, team said. ...
Breaking Medicine News(10 mins):Health News:Recent Special “Autism” Code on Virginia Driver’s Licenses and ID Cards Goes into Law: Helpful or Discriminatory for Individuals on the Autistic Spectrum? 2Health News:Recent Special “Autism” Code on Virginia Driver’s Licenses and ID Cards Goes into Law: Helpful or Discriminatory for Individuals on the Autistic Spectrum? 3Health News:Georgia State Hosts National Conference On Aggression 2Health News:Georgia State Hosts National Conference On Aggression 3Health News:Georgia State Hosts National Conference On Aggression 4Health News:Register to Download Merrill DataSite's Report: Capitalizing on the Shifting Sands of the Energy Market 2Health News:Latest A Forever Recovery Launches Eating Disorders Section on Website 2Health News:Like Humans, Chimps' Smarts May Rely on Genes 2
... research reports published in the new issue of Archives ... vascular birthmarks with treatment procedures like laser therapy and ... internal, or form an external birthmark and can be ... ,The researchers had presented the current treatment approaches for ...
... genetic disorder characterized by distorted, sickle shaped red blood cells. ... damage to the kidneys, spleen, and liver. The sickle cell ... is about 1 in 500., ,Despite much clinical work, ... can be relieved, and the frequency and duration of the ...
... Researchers at the University of California in San Francisco ... fruit and vegetables can reduce the risk of pancreatic ... most strongly associated with increased // protection were onions, ... potatoes, corn and yellow squash), dark leafy vegetables and ...
... medical journal The Lancet had published a research ... health workers., ,Poor health-worker performance is a ... In the current issue of The Lancet researchers ... for how high-quality health-worker performance can be achieved., ...
... Molecular Immunologist and his team has found a new virus ... inflammation and autoimmune diseases. The new delivery system acts as ... virus containing the required genes are transferred into the T ... the immune cells they get attracted towards the cancer cell ...
... have been reported to experience 25% less muscle and joint ... active. Furthermore, the study has also revealed that people who ... experience less pain than non-runners even though they are more ... study involved comparison of the level of pain in a ...
Cached Medicine News:Health News:Hydroxyurea Treatment For Children With Sickle Cell Disease 2
(Date:7/10/2014)... July 10, 2014   Ventana Medical Systems, Inc. ... it has entered into an agreement with Merck KGaA, ... EMD Serono in the United States ... with Merck KGaA,s biopharmaceutical division on the development and ... target using Ventana,s proprietary diagnostic assays. In alignment with ...
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
(Date:1/15/2014)... DALLAS , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com ... to its store . (Photo: ... consumption upgrade and policy support, China,s ... the years, with total market size rising from 3.28 ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... ,, NEW YORK , May 17 Reportlinker.com announces that a ... , , ... , , ... This report analyzes the ...
... 17 CareFusion (NYSE: CFN ), a leading, global ... Medegen, a leading innovator in clinically differentiated needleless access connectors and administration ... in cash. , , ... CareFusion is an industry leader in IV infusion devices with its Alaris® ...
Cached Medicine Technology:Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 2Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 3Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 4Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 5Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 6Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 7Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 8Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 9Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 10Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 11Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 12Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 13Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 14Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 15Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 16Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 17Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 18Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 19Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 20Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 21Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 22Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 23Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 24Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 25Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 26Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 27Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 28Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 29Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 30Reportlinker Adds Global Pulmonary Drug Delivery Technologies industry 31CareFusion Completes Medegen Acquisition 2
... helps you deliver unmatched performance through patient-focused ... the most complete anesthesia solution developed, putting ... - at your fingertips., ,The Aisys ... legacy of anesthesia delivery and patient monitoring ...
... Premilene Mesh LP Self-Forming Plug is combining ... This results in a very soft hernia plug ... to standard Plugs less foreign body material is ... the hernia size and shape allows for a ...
... Celsius Control System provides physicians,with ... safely,and rapidly lower patient body ... temperature and,rewarm patients to normothermic ... consists of an endovascular,catheter, console ...
... Fiberoptics Gemini surgical headlight is perfectly balanced ... durable and ultra-low-profile and illuminates brilliantly while ... annoying "rams effect." The fully adjustable headband, ... to sit low on the brow, directing ...
Medicine Products: