Navigation Links
Right first time: Pioneering new methods of drug manufacture
Date:11/11/2009

Engineers at the University of Leeds have developed a simple technology which can be used in existing chemical reactors to ensure "right first time" drug crystal formation.

Ensuring drug crystals are formed correctly is crucial to their efficacy and the efficiency of pharmaceutical manufacturers' operations. Using self-assembled monolayers, the team has been able to show that crystals form into their desired product form with the correct shape and particle structure, without the usual problems of polymorphism which results in huge losses to the pharmaceutical sector each year.

"If you imagine the way that oil sits on top of water, that's similar to how the monolayer works," says Professor Kevin Roberts of University's Faculty of Engineering. "We've shown that we can produce a well-defined crystal structure using a self-assembled monolayer bound onto a metal substrate within a regular reactor. This is exciting stuff, because it's a relatively simple system, but could make a huge difference in the efficiency of drug manufacture."

One of the first stages of the crystallisation process is called nucleation. During nucleation, particles are introduced into a reactor to encourage the formation of crystals. However, the way in which this is currently carried out is difficult to control and can often lead to the wrong shape, size or structure of drug crystal, something which affects the usefulness and efficacy of the compound.

The new system proven to work by the Leeds team, working alongside Ana Kwokal from Croatian pharmaceutical company PLIVA, has shown that introducing a self-assembled monolayer a layer of self-organising molecules that is attractive to the substance being crystallised into a reactor enables consistent crystal formation.

Professor Roberts says: "Because this is a really simple solution to ensuring consistent crystallisation, it has huge potential commercially. Our next steps are to make sure it's just as efficient on an industrial scale."

This work draws on previous research and experimental systems developed through the Chemicals Behaving Badly II initiative, an Engineering and Physical Sciences Research Council (EPSRC) programme which includes universities and industrial partners.


'/>"/>

Contact: Clare Elsley
Clare@campuspr.co.uk
44-113-258-9880
University of Leeds
Source:Eurekalert

Related medicine news :

1. Physicians for Human Rights Offers Training in Crime Scene Documentation
2. Bright Horizons Named One of Boston Globe 100s Top Places to Work
3. Good Sleepers More Likely to Eat Right
4. Mom was right: Nice guys dont always finish last
5. Rights Tracker Completes Fundraising
6. Lloyd Wright's Alternative Medicine Marketing Only Blueberry Extract with 45% of Hepatitis C Inhibitor Proanthocyanidin
7. Morphotek(R), Inc. Announces a Licensing Deal With Centocor Ortho Biotech Inc. for Exclusive Development and Commercialization Rights for a Therapeutic Monoclonal Antibody
8. AHIP Is Right, and May Be Low
9. Researchers discover mechanism that helps humans see in bright and low light
10. Go Healthy Secures Nationwide Distributorship Rights to Patented Drinking Water
11. Right Now Sale/Leaseback May Be the Only Option to Obtain Cash and a Healthier Balance Sheet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2017)... ... July 24, 2017 , ... Three experts ... Medicine (AAPM) 59th Annual Meeting & Exhibition, to be held in Denver, CO ... hospital administrators and journalists can visit the AAPM Facebook page to watch three ...
(Date:7/23/2017)... Rosa, CA (PRWEB) , ... July 23, 2017 , ... ... of Medicine in St. Louis, and led by the Minneapolis Veterans Administration Health Care ... early stages of the disease offers very few benefits. , In the cases ...
(Date:7/23/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 23, ... ... the effects of single sport specialization is critical, say researchers presenting their work ... Meeting in Toronto, Canada. , “Our study is the first one to ...
(Date:7/23/2017)... ... 23, 2017 , ... Technology is making it easier for ... tools are helping patients become more actively involved in their care and maintaining ... survey, released today by the American Hospital Association’s (AHA) Health Forum. , According ...
(Date:7/23/2017)... ... 23, 2017 , ... Longtime Brevard County pain management specialist ... practice owned by Physician Partners of America at 109 Silver Palm Ave. , ... certified in pediatrics, emergency medicine and anesthesiology. , A longtime practitioner in the ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... FREMONT, Calif. , July 13, 2017 RK ... (CA) Board of Pharmacy certification for its Fremont, ... chain support solutions in the Tri-Valley and San ... The City of Fremont , with its ... Logistics Group to provide such a powerful resource to the ...
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
(Date:7/10/2017)...  US medical equipment and supply demand is forecast ... Medical Equipment & Supplies: United States , ... increases in demand for medical services – driven in ... supported by gains in disposable personal income – will ... introductions will also drive sales as providers and patients ...
Breaking Medicine Technology: