Rigel to Webcast Investor Update on Octobe... ( SOUTH SAN FRANCISCO Calif. Oct. 2...)

Rigel to Webcast Investor Update on October 27, 2008

Date:10/21/2008

SOUTH SAN FRANCISCO, Calif., Oct. 21 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that it will webcast its investor update, in conjunction with the American College of Rheumatology Meeting (ACR), on October 27, 2008 from 2:00-3:00pm Pacific Time. Members of Rigel's senior management team will provide an update on the company's lead product candidate, R788, a novel, oral Syk kinase inhibitor. R788 is currently being evaluated in two Phase 2b clinical trials in patients with rheumatoid arthritis, as well as Phase 2 clinical trials in immune thrombocytopenic purpura and B-cell lymphomas.

The event will be webcast live and can be accessed from Rigel's website at http://www.rigel.com. Please connect to Rigel's website several minutes prior to the start of the live webcast to ensure adequate time for any software downloads that may be necessary. The webcast will be archived and available for replay on the Company's website.

In addition, Rigel will be participating in both a plenary session and a poster session during ACR in San Francisco, California from October 24-29, 2008.

ACR Presentation Details

Plenary session: Monday, Oct 27, 12:15-12:30 PM

Session: Discovery 2008: Pathogenesis and Treatment of Inflammatory

Arthritis

Title: 1189 - Treatment of Rheumatoid Arthritis (RA) with a Syk Kinase

Inhibitor: A 12-week randomized placebo controlled study

Location: Hall C

Poster session: Tuesday, Oct 28, 9:00-11:00 AM

Session: Biology and Pathology of Bone and Cartilage

Title: 1293 - R406, a Small Molecule Syk inhibitor, Suppresses Osteoclast

Differentiation of Murine Bone Mar
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