Navigation Links
Rifampin: Latent TB treatment saves time money and lives

ATS 2008, TORONTOA new way to treat patients with latent tuberculosis (TB), who are infected with TB but without symptoms, can effectively treat it in less than half the time and at a lower cost than the current standard treatment, according to researchers who conducted a multi-center, randomized controlled trial. The results will be presented at the American Thoracic Societys 2008 International Conference in Toronto on Tuesday, May 20.

We found that using a therapy of four months of Rifampin instead of the current nine months of Isoniazid costs significantly less for the healthcare system, said lead analyst, Anne Aspler, M.Sc., of the Respiratory Epidemiology & Clinical Research Unit at McGill Universitys Montreal Chest Institute. Overall, Rifampin costs about $484 less per patient treated, which, if we assume that four months of Rifampin has at least equal efficacy to nine months of Isoniazid, represents an added savings to the health system of more than $10,000 per patient prevented from developing TB disease. And because of improvements in compliance, we are actually preventing more cases. This treatment can save money as well as lives.

At present, two billion people are believed to have latent or dormant TB. Of those infected, eight to nine million will develop TB each year, of whom 1.6 million will die. This is one of the most pressing public health crises in our modern world, said Ms. Aspler.

Rifampin is offered in developing countries, where TB presents the greatest burden, at a subsidized cost through the Global Drug Facility of the World Health Organization. In addition to the cost savings, therapy with Rifampin has the advantage of increased compliance.

While Isoniazid therapy is 90 percent effective for those who complete it, in reality, fewer than 50 percent do, Ms. Aspler explained. The high attrition rate can have serious public heath effects, not only for the patients who fail to complete therapy, but also for the individuals they may later infect.

According to previous research and program experience in Maryland and New Jersey, a four-month treatment has been shown to improve compliance by 20 to 25 percent. In addition to better completion rates, a four-month course of Rifampin offers the advantages of fewer adverse reactions (fewer serious side effects such as hepatotoxicity or liver damage), and lower costs.

The next step in research is a major Phase III clinical trial of efficacyideally in HIV-infected and non-infected patients and in low-income settings where tuberculosis is the leading cause of death in people living with HIV, said Ms. Aspler.


Contact: Keely Savoie
American Thoracic Society

Related medicine news :

1. New chemical can kill latent tuberculosis bacteria
2. New treatment gives hope for pulmonary fibrosis patients
3. Mission Pharmacal Launches Ferralet(R) 90 for Treatment of the Leading Cause of Anemia in the U.S.
4. Monitoring whether patients take medicines can help anticipate HIV treatment failure in Africa
5. Mapping of prostate cancer genes opens the door to new treatments
6. Many Diabetics Dont Get Necessary Blood Pressure Treatment
7. MR imaging accurately determines prostate cancer treatment failure
8. Study: Patients 75 years and older with brain tumors may benefit from more aggressive treatment
9. Old antibiotic may find new life as a stroke treatment
10. Radiofrequency ablation is effective treatment for dysplasia in Barretts esophagus
11. New Hair Loss Treatment Proves Effectiveness
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... ... the perfect dish and pleasing the palates of attendees is of the utmost ... dish to a seasonal get-together, give these recipes a try this holiday season. ...
(Date:11/25/2015)... , ... November 26, 2015 , ... ... Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and public ... in Nairobi (UNON) for the opening of the 5th African Network for Drugs ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would like to become more ... to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be ... As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for the ... of the benefits of Botox® in the treatment of moderate facial wrinkling, few have ... pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism (the ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... “While riding ... an inventor, from Bronx, N.Y. “I thought there had to be a convenient and ... the PROTECTOR. , The PROTECTOR enables disabled individuals to safely travel during cold or ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- Research and Markets ( ) has announced ... by Type (Dressings, Therapy Devices, Active Wound Care), Application ... and Geography - Global Forecast to 2020" report ... --> The purpose of this report is ... global advanced wound care market. It involves deep dive ...
(Date:11/26/2015)... India , November 26, 2015 ... --> adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... . ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Italian therapeutic drug monitoring market, including ...
Breaking Medicine Technology: