Navigation Links
Rice University technology in human trials to spot cardiac disease, cancer, drug abuse
Date:2/9/2011

Heart disease is a silent killer, but new microchip technology from Rice University is expected to advance the art of diagnosis.

During National Heart Health Month, Rice Professor John McDevitt will discuss the potential of this technology to detect cardiac disease early at the annual meeting of the American Association for the Advancement of Science (AAAS) in Washington, D.C., Feb. 17-21. Cardiac disease is the focus of one of six ongoing major clinical trials of Rice's programmable bio-nano-chips (PBNCs).

PBNCs combine microfluidics, nanotechnology, advanced optics and electronics to enable quick, painless diagnostic tests for a wide range of diseases at minimal cost.

Current clinical trials employ PBNCs to test more than 4,000 patients for signs of heart disease, ovarian cancer, prostate cancer, oral cancer and drug abuse. Versions to test for HIV/AIDS and other diseases are also in development.

"Too often, the first time people know they're suffering from heart disease is when it kills them," said McDevitt, Rice's Brown-Wiess Professor of Chemistry and Bioengineering, who will participate in a global health seminar at AAAS.

"With this test, we expect to save lives and dramatically cut the recovery time and cost of caring for those who suffer from heart ailments," said McDevitt, a pioneer in the creation of microfluidic devices for biomedical testing. He anticipates the PBNCs, when manufactured in bulk, will cost only a few dollars each.

PBNCs analyze a patient's saliva for biomarkers associated with cardiovascular disease. Unfortunately, McDevitt said, only about half of the patients having a heart attack are diagnosed immediately via electrocardiogram. The rest require a series of time-consuming laboratory tests that take up to 12 hours to complete. PBNCs now in development deliver results in as little as 20 minutes and provide clinicians with timely information that can help them manage patients more effectively.

"A critical thing to recognize in a heart attack is that if we're able to open the blocked vessel within an hour, we've salvaged a heart muscle," said Biykem Bozkurt, the Mary and Gordon Cain Chair and Professor of Medicine and director of the Winters Center for Heart Failure Research at Baylor College of Medicine (BCM). "Thus, the patient's chance of survival is significantly improved."

Bozkurt and Christie Ballantyne, chief of atherosclerosis and vascular medicine and professor of medicine at BCM and director of the Center for Cardiovascular Disease Prevention at the Methodist DeBakey Heart and Vascular Center, are leading the trial at Houston's Michael E. DeBakey VA Medical Center, one of four sites hosting the cardiac trial that will recruit 1,000 patients.

McDevitt noted that of 5 million visits to American emergency rooms each year for chest pain, approximately 80 percent are false alarms.

"We have patients clogging the ER system and delaying the recognition of true heart attack cases because we can't, in an expeditious manner, rule out false alarms that could have been diagnosed in the ambulance or the home setting," said Bozkurt, who also serves as cardiology section chief at the VA.

The potential cost savings for even a single patient are tremendous, said Vivian Ho, the James A. Baker III Institute Chair in Health Economics and a professor of economics at Rice.

"Treating patients in the emergency room is one of the highest costs we have in the health care system," Ho said, "particularly for heart attacks, because heart disease is the leading killer of Americans and it accounts for a large proportion of our health care costs.

"If we can identify these patients quickly so we can avoid aggressive diagnostic tests further on down the road -- for example, cardiac catheterizations and procedures that cost tens of thousands of dollars -- by instead using a relatively low-cost diagnostic chip, that's a tremendous opportunity to provide better care and lower costs," she said.

McDevitt expects PBNCs and their toaster-sized reader will ultimately find a place at many points of care -- hospitals, doctors' or dentists' offices, pharmacies and remote clinics worldwide -- where they will allow clinicians to quickly diagnose a variety of ailments.

He anticipates Rice's BioScience Research Collaborative, part of the Texas Medical Center, to be the hub of a pipeline in which chips will be programmed to spot biomarkers for many important diseases.

"PNBC technology marries medical devices and microelectronics," McDevitt said, "and it has the potential to revolutionize the flow of information in the practice of medicine while significantly reducing cost. I like to think of it as the iPhone of medicine, with the same potential to be a game changer. And it's just around the corner."


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Related medicine news :

1. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
2. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
3. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
4. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
5. Smithsonian Institution, Arizona State University announce education and research partnership
6. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
7. Giarmarco, Mullins & Horton, P.C. President Joseph F. Page to Speak at University of Michigan
8. Arizona State Universitys Decision Theater offers balance to an off-kilter world
9. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
10. Herzing University Online Launches Master and Bachelor of Science Degrees in Nursing
11. Nurtur Acquires ActivHealth and Wellness by Choice; Gains Exclusive Partnership with Duke University Center for Living
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Oct. 12, 2017 AVACEN Medical , Inc. ... with their  2017 New Product Innovation Award for Its ... primary and secondary medical device market research by Frost & ... first-to-market OTC, drug-free pain relief product, the AVACEN 100, offers ... treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
Breaking Medicine Technology: