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Rib-X Granted Key Antibiotic Patent in China

NEW HAVEN, Conn., April 15 /PRNewswire/ -- Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery and development of novel antibiotics for the treatment of antibiotic-resistant infections, today announced the issuance of a key antibiotic patent in China. The State Intellectual Property Office of the People's Republic of China has issued Chinese Patent Number ZL 2004 8 0021883.9 to Rib-X. This patent provides composition of matter protection for Rib-X's novel oxazolidinone antibiotic, radezolid. Rib-X has established a broad patent portfolio related to radezolid, including the issuance of composition of matter for radezolid in the US. The Company anticipates issuance of additional patents in all major and emerging markets.

"This Chinese patent strengthens Rib-X's existing intellectual property portfolio and underscores our ability to successfully design and develop antibiotics that overcome resistant bacteria," said Susan Froshauer, Ph.D., President and CEO of Rib-X Pharmaceuticals. "China is the world's largest emerging pharmaceutical market, and the issuance of this patent enhances Rib-X's commercial opportunities in this important region of the world."

About Radezolid

Radezolid is a novel oxazolidinone that was discovered using Rib-X's proprietary discovery process and was designed to expand the bacterial spectrum and improve the utility of this class of antibiotics relative to the only other oxazolidinone marketed in the world, Zyvox(R) (linezolid). Rib-X is developing both oral and IV formulations for use in serious hospital gram positive infections, including those caused by MRSA and linezolid- and vancomycin-resistant enterococci. Radezolid is the subject of a second ongoing Phase 2 clinical trial for community acquired pneumonia (CAP). This compound has been shown to be microbiologically more active than linezolid against Gram-positive organisms, including potent activity against linezolid resistant bacteria, in prior studies.

About Rib-X Pharmaceuticals, Inc.

Rib-X Pharmaceuticals, Inc. is a product-driven small molecule drug discovery and development company focused on the structure-based design of new classes of antibiotics. The Company's underlying drug discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in protein synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ribosome. The Company's integrated research strategy, which combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, allows it to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X's iterative intelligent engine has yielded several distinctive new antibiotics that can be used for the treatment of either community- or hospital-acquired infections. In addition to delafloxacin, Rib-X is currently in Phase 2 trials with radezolid (RX-1741), an oxazolidinone that was discovered at Rib-X, as an oral/IV agent for treatment of serious Gram-positive infections. The Rx-04 discovery program is developing novel classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the Rx-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus, multidrug-resistant Streptococcus pneumoniae and S. pyogenes. Both delafloxacin and radezolid are currently in Phase 2 clinical trials.

For more information on Rib-X, please visit the Company website at

SOURCE Rib-X Pharmaceuticals, Inc.
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