Navigation Links
Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients
Date:2/2/2009

LOS ANGELES (Feb. 2, 2009) Researchers conducting a large, ongoing study to improve detection and prevention of sudden cardiac death were surprised to discover that a specific heart rhythm abnormality idiopathic QT interval prolongation increased risk five-fold among patients with coronary artery disease.

"More than 80 percent of all cases of sudden cardiac death occur in people who have significant coronary artery disease, but we currently do not have a medical test that consistently identifies patients at risk," said Sumeet S. Chugh, M.D., associate director of the Cedars-Sinai Heart Institute and director of Clinical Electrophysiology. Chugh is first author of an article in Circulation, now appearing online ahead of print. This research was conducted with colleagues in the Emergency Medicine and Pathology Departments at Oregon Health and Science University in Portland, as part of the ongoing Oregon Sudden Unexpected Death Study.

"Abnormal QT prolongation has significant potential for evaluating risk and developing prevention strategies, but there are many factors some known and some not known that contribute to QT prolongation. Diabetes and the use of certain medications were significant predictors of QT interval prolongation and sudden cardiac death risk in our study. However, the most interesting and somewhat unexpected finding was that abnormally prolonged QT interval of unknown etiology independent of diabetes, medications and other factors was an even more powerful predictor of sudden cardiac death, with a five-fold increase in odds," said Chugh, who holds the Pauline and Harold Price Chair in Cardiac Electrophysiology Research.

The researchers noted that several gene variations have been linked to prolonged QT intervals, and the discovery of new genetic associations are likely to improve risk-assessment and intervention strategies. "The continued identification of gene variants that determine QT interval duration has become an important scientific priority in the field," Chugh said.

"QT interval" refers to electrical activity that occurs in the main pumping chambers of the heart, the ventricles. It includes the Q, R, S, and T waves seen on an electrocardiogram. Unlike heart attacks, which are typically caused by clogged coronary arteries, sudden cardiac arrest is the result of defective electrical impulses.


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-170-880-088-02397
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Mouse vision has a rhythm all its own
2. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
3. St. Davids Medical Center Implements New Robotic Technology to Treat Common Heart Rhythm Disorders
4. Practice parameters discuss the evaluation, treatment of circadian rhythm sleep disorders
5. FDA Reviewing Potential Anti-Arrhythmic Claims for Ranexa(R)
6. New insights into deadly heart rhythm disorder
7. Cleveland Clinic Recruits World Renowned Heart Rhythm Specialist to Direct Electrophysiology
8. Popular arthritis drug may disrupt heart rhythm, UB research finds
9. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
10. Angina drug potentially useful against heart rhythm disorders
11. Intelligence and rhythmic accuracy go hand in hand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: