Navigation Links
Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients
Date:2/2/2009

LOS ANGELES (Feb. 2, 2009) Researchers conducting a large, ongoing study to improve detection and prevention of sudden cardiac death were surprised to discover that a specific heart rhythm abnormality idiopathic QT interval prolongation increased risk five-fold among patients with coronary artery disease.

"More than 80 percent of all cases of sudden cardiac death occur in people who have significant coronary artery disease, but we currently do not have a medical test that consistently identifies patients at risk," said Sumeet S. Chugh, M.D., associate director of the Cedars-Sinai Heart Institute and director of Clinical Electrophysiology. Chugh is first author of an article in Circulation, now appearing online ahead of print. This research was conducted with colleagues in the Emergency Medicine and Pathology Departments at Oregon Health and Science University in Portland, as part of the ongoing Oregon Sudden Unexpected Death Study.

"Abnormal QT prolongation has significant potential for evaluating risk and developing prevention strategies, but there are many factors some known and some not known that contribute to QT prolongation. Diabetes and the use of certain medications were significant predictors of QT interval prolongation and sudden cardiac death risk in our study. However, the most interesting and somewhat unexpected finding was that abnormally prolonged QT interval of unknown etiology independent of diabetes, medications and other factors was an even more powerful predictor of sudden cardiac death, with a five-fold increase in odds," said Chugh, who holds the Pauline and Harold Price Chair in Cardiac Electrophysiology Research.

The researchers noted that several gene variations have been linked to prolonged QT intervals, and the discovery of new genetic associations are likely to improve risk-assessment and intervention strategies. "The continued identification of gene variants that determine QT interval duration has become an important scientific priority in the field," Chugh said.

"QT interval" refers to electrical activity that occurs in the main pumping chambers of the heart, the ventricles. It includes the Q, R, S, and T waves seen on an electrocardiogram. Unlike heart attacks, which are typically caused by clogged coronary arteries, sudden cardiac arrest is the result of defective electrical impulses.


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-170-880-088-02397
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Mouse vision has a rhythm all its own
2. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
3. St. Davids Medical Center Implements New Robotic Technology to Treat Common Heart Rhythm Disorders
4. Practice parameters discuss the evaluation, treatment of circadian rhythm sleep disorders
5. FDA Reviewing Potential Anti-Arrhythmic Claims for Ranexa(R)
6. New insights into deadly heart rhythm disorder
7. Cleveland Clinic Recruits World Renowned Heart Rhythm Specialist to Direct Electrophysiology
8. Popular arthritis drug may disrupt heart rhythm, UB research finds
9. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
10. Angina drug potentially useful against heart rhythm disorders
11. Intelligence and rhythmic accuracy go hand in hand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... 2017 , ... “Just What Happened in the Garden of Eden”: retells the stories of three ... the creation of published author, Penelope Colt, mother, trader, horse farmer, artist and a former ... she was three. At six, they moved to Dayton, Ohio, where Penny graduated high ...
(Date:5/24/2017)... ... May 24, 2017 , ... Last month, representatives from Rendina ... and town officials to celebrate the grand opening of the 87,000 square foot ... part of its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. ...
(Date:5/24/2017)... ... May 24, 2017 , ... Altec Products, Inc., a leader ... – a one-day technology conference in San Diego, CA. , At nVerge 2017, ... to fully utilize and enhance their Sage ERP solutions by providing improved visibility and ...
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Manju R. Kejriwal, ... ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands the emotional and ... convenient, clear braces in Cincinnati, OH. Patients no longer need to feel the esthetic ...
(Date:5/24/2017)... ... , ... Myers Jackson is well known for auctioning homes that people move ... on the planet. The luxury home market is alive and well and there are ... search of “11 Spyglass Hill Auction will enlighten you on the dynamics of how ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... , May 9, 2017 Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced it has earned a spot ... 2017" list. The Company was ranked among 500 U.S. ... Employers and Healthcare Equipment and Services. The ... on an anonymous, independent survey of over 30,000 employees ...
(Date:5/8/2017)... 2017 MACRA replaces the outdated sustainable ... service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician practices ... The Market for MIPS Compliance Technology is Booming ... with 3 or more clinicians seek to buy Merit-Based ... the magnitude of the changes, the hunt is on ...
(Date:5/6/2017)... N.Y. , May 5, 2017  Hill-Rom Holdings, ... will add approximately 100,000 square feet to its Welch ... September 2016 its commitment to bring more than 100 ... , where Welch Allyn has maintained a significant presence ... help accommodate these new positions, a large portion of ...
Breaking Medicine Technology: