Navigation Links
Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients
Date:2/2/2009

LOS ANGELES (Feb. 2, 2009) Researchers conducting a large, ongoing study to improve detection and prevention of sudden cardiac death were surprised to discover that a specific heart rhythm abnormality idiopathic QT interval prolongation increased risk five-fold among patients with coronary artery disease.

"More than 80 percent of all cases of sudden cardiac death occur in people who have significant coronary artery disease, but we currently do not have a medical test that consistently identifies patients at risk," said Sumeet S. Chugh, M.D., associate director of the Cedars-Sinai Heart Institute and director of Clinical Electrophysiology. Chugh is first author of an article in Circulation, now appearing online ahead of print. This research was conducted with colleagues in the Emergency Medicine and Pathology Departments at Oregon Health and Science University in Portland, as part of the ongoing Oregon Sudden Unexpected Death Study.

"Abnormal QT prolongation has significant potential for evaluating risk and developing prevention strategies, but there are many factors some known and some not known that contribute to QT prolongation. Diabetes and the use of certain medications were significant predictors of QT interval prolongation and sudden cardiac death risk in our study. However, the most interesting and somewhat unexpected finding was that abnormally prolonged QT interval of unknown etiology independent of diabetes, medications and other factors was an even more powerful predictor of sudden cardiac death, with a five-fold increase in odds," said Chugh, who holds the Pauline and Harold Price Chair in Cardiac Electrophysiology Research.

The researchers noted that several gene variations have been linked to prolonged QT intervals, and the discovery of new genetic associations are likely to improve risk-assessment and intervention strategies. "The continued identification of gene variants that determine QT interval duration has become an important scientific priority in the field," Chugh said.

"QT interval" refers to electrical activity that occurs in the main pumping chambers of the heart, the ventricles. It includes the Q, R, S, and T waves seen on an electrocardiogram. Unlike heart attacks, which are typically caused by clogged coronary arteries, sudden cardiac arrest is the result of defective electrical impulses.


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-170-880-088-02397
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Mouse vision has a rhythm all its own
2. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
3. St. Davids Medical Center Implements New Robotic Technology to Treat Common Heart Rhythm Disorders
4. Practice parameters discuss the evaluation, treatment of circadian rhythm sleep disorders
5. FDA Reviewing Potential Anti-Arrhythmic Claims for Ranexa(R)
6. New insights into deadly heart rhythm disorder
7. Cleveland Clinic Recruits World Renowned Heart Rhythm Specialist to Direct Electrophysiology
8. Popular arthritis drug may disrupt heart rhythm, UB research finds
9. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
10. Angina drug potentially useful against heart rhythm disorders
11. Intelligence and rhythmic accuracy go hand in hand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
(Date:6/23/2016)... Tenn. , June 23, 2016 /PRNewswire/ ... automating, integrating and transforming the patient payment ... of several innovative new products and services ... of its revenue cycle offerings. These award-winning ... more efficient workflows, remain compliant in an ...
(Date:6/23/2016)... -- The National Pharmaceutical Council (NPC) today announced that ... organization as its newest member.  ... and chief scientific officer, Mallinckrodt Pharmaceuticals, will serve ... of Directors. ... in support of our efforts to conduct research ...
Breaking Medicine Technology: