Navigation Links
Rhode Island Hospital studies uncover keys in sudden cardiac death
Date:1/17/2012

Journal of Physiology, the researchers used this animal model to identify differential conditions and cellular mechanisms that trigger arrhythmia in LQT1 or in LQT2 syndrome. In this study, Koren and the researchers studied early afterdepolarizations (EADs), an abnormal depolarization during the plateau phase of the heart electrical activity (action potential) that can initiate arrhythmia, and a hallmark of LQTS. The focus was on mechanisms underlying different high-risk conditions that trigger EADs.

Their findings indicate that the conditions required for EAD to occur in the animal models are genotype specific. For LQT2, the researchers found that conditions such as a slow heart rate or a slightly lower potassium ion concentration outside the heart cells (as seen in hypokalemia) can cause a dramatic prolongation of action potential and produce triggered activity (EADs). In LQT1, however, these conditions result in relatively limited prolongation and no EADs. In contrast, isoproterenol that mimics cardiac stimulation by the sympathetic system causes arrhythmias in single cells only in LQT1 heart cells.

Koren summarizes, "This study takes single cells out of the heart and reveals how arrhythmias are being initiated. What we are showing in this study is that single cells are responsible for generating an arrhythmia. Further, we found that different types of increased autonomic nervous system activity play a critical role in the cause of arrhythmias and sudden cardiac death, but it differs based on genotype."

The autonomic nervous system is what controls "fight or flight" response. In their research, Koren and his colleagues found that sympathetic "surge" activity was responsible for triggering arrhythmia in LQT2. In LQT1, however, an increased steady sympathetic tone was associated with arrhythmias.

Surge is a sudden rise of the sympathetic tone. That surge is very important in triggering arrhythmia in LQT2. As Koren explains, "I
'/>"/>

Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Rhode Island Hospital finds lack of testing for Legionella
2. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
3. Rhode Island Hospital study identifies fish oils impact on cognition and brain structure
4. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
5. Rhode Island Hospital fellow receives funding to support research in myocardial perfusion
6. Paper by Rhode Island Hospital physician selected among best of 2010 by JACR
7. Women & Infants launches Rhode Island Network for Pelvic Floor Disorders
8. Rhode Island Hospital physician receives national award for research
9. Rhode Island Settlement Reflects Homeowner Liability for Serving Alcohol to Those Under 21, Says Providence Lawyer Mark Gemma
10. What will climate change and sea level rise mean for barrier islands?
11. Sea grant awards more than $1.1 million for research under EPAs Long Island Sound study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rhode Island Hospital studies uncover keys in sudden cardiac death
(Date:8/19/2014)... Crosley Law Firm, PC has reached a confidential settlement ... Bakery for an undisclosed amount. The two claimants, Pete Gonzales ... 2011, respectively. The injuries were caused by two different machines ... the left hand of each man. , At the time ... having lost 200 of its, 500 workers in connection with ...
(Date:8/19/2014)... An editorial published in this week,s JAMA ... clinical assessment tools when considering how to treat patients. ... Boston Medical Center and chair of pediatrics at Boston ... of JAMA , the editorial examines results of ... journal as an example of how doctors can often ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Kars4Kids ... youth programs, announced today its partnership with New York ... needy students in the Bronx. The giveaway will take ... Fair in Crotona Park on August 22. , ... opportunities, we believe properly preparing children for school with ...
(Date:8/19/2014)... “ Inbox Blueprint 2.0 ” from ... provide users with the tools necessary to build and ... strategies. The course which was originally launched in ... the internet marketing world. The commotion surrounding the products ... prompting an updated review of the course material. ...
(Date:8/19/2014)... TUESDAY, Aug. 19, 2014 (HealthDay News) -- Lupus ... such as headaches and seizures, which can delay ... says. Treatments for rheumatic diseases can also ... at Loyola University Medical Center in Maywood, ... of the joints and soft tissues, such as ...
Breaking Medicine News(10 mins):Health News:Crosley Law Firm Reaches Settlement for Hand Amputation Victims at Commercial Bakery 2Health News:Review of clinical treatment of bronchiolitis in infants reveals over-reliance on one test 2Health News:Backpack Giveaway Kars4Kids Partners with New York State Senator Gustavo Rivera to Prepare Bronx Students for New School Year 2Health News:Anik Singal’s “Inbox Blueprint” Review Released By HonestyFirstReviews.com 2Health News:Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report 2
... plot, emotional melodrama is a subtype of dramatic ... part of the consumer. Often labelled chick-flicks, tearjerkers, ... form of entertainment is underscored by the popularity ... Oprah Winfrey Show. However, despite the apparent popularity ...
... GAINESVILLE, Fla. --- If the human body were a ... in the play we call Life. , These ... lines are dictated by information encoded in our genes. ... living and controlling countless functions. Many are enzymes that ...
... a 1990 consensus recommendation from the National Institutes of ... of choice for early stage breast cancer, the United ... surgery among industrialized countries. Why would a person knowingly ... a lesser one would suffice? A recent survey shows ...
... Prevent Sudden Cardiac Arrest,Through Public Education and Advocacy, ... announced today that it has launched a Southwest,Connecticut chapter ... affiliate,organizations, as it builds a network of local organizations ... arrest (SCA)., The Southwest Connecticut chapter is based ...
... Will Work to Prevent Sudden Cardiac Arrest, Through ... The Sudden Cardiac Arrest,Association (SCAA) announced today that it ... network of local organizations to help carry out its,mission ... Kansas City SCAA chapter is led by Patrick Emmett ...
... Work to Prevent Sudden Cardiac Arrest, Through Public ... Sudden Cardiac Arrest,Association (SCAA) announced today that it has ... of local organizations to help carry out,its mission of ... chapter is led by Connie Snell of Austin who ...
Cached Medicine News:Health News:True story? Men prefer 'chick flicks' when they are explicitly fictionalized 2Health News:Protein power: Researchers trigger insulin production in diabetic mice 2Health News:Protein power: Researchers trigger insulin production in diabetic mice 3Health News:American women are more likely to choose overly aggressive treatments for breast cancer 2Health News:Sudden Cardiac Arrest Association Launches Southwest Connecticut Chapter 2Health News:Sudden Cardiac Arrest Association Launches Southwest Connecticut Chapter 3Health News:Sudden Cardiac Arrest Association Launches Kansas City Chapter 2Health News:Sudden Cardiac Arrest Association Launches Kansas City Chapter 3Health News:Sudden Cardiac Arrest Association Launches Austin and Lubbock Chapters 2Health News:Sudden Cardiac Arrest Association Launches Austin and Lubbock Chapters 3
(Date:8/19/2014)... , Aug. 19, 2014  The Alabama Supreme Court, ... patients can sue drug makers who mislead doctors into believing ... side‑effects.  The case is Weeks v. Wyeth, and the decision ... in that same case last year. Heninger Garrison Davis attorneys ... the patient in the case, Danny Weeks . ...
(Date:8/19/2014)... 2014 Minimally Invasive Devices Inc. (MID), a ... announced today that Mitsubishi Corporation has formally agreed to ... in Japan . MID anticipates that ... Japan in the second half of 2015. ... for Karl Storz GMBH & Co. (endoscopic instruments and ...
(Date:8/19/2014)...  As power morcellator lawsuits continue to mount ... notes that women in need of fibroid removal ... options that do not involve the use of ... report published by The Wall Street Journal on ... mini-laparotomy and vaginal hysterectomy. Non-surgical options for shrinking ...
Breaking Medicine Technology:Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 2Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 3Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 4Minimally Invasive Devices and Mitsubishi Medical Japan Forge Exclusive Distribution Agreement 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 3
... Valeant Pharmaceuticals International, Inc. (NYSE/TSX: VRX) today ... credit facilities of its wholly owned subsidiary Valeant ... by the Company.  The proposed $1.7 billion senior ... a $200 million revolving facility and a $1.5 ...
... 20, 2011 – Ingenuity® Systems, a leading ... life science researchers, today announced the addition ... from miRecords , plus thousands of ... peer-reviewed literature. The newly added content supplements ...
Cached Medicine Technology:Valeant Pharmaceuticals to Refinance Senior Secured Credit Facilities 2Ingenuity Announces New Additional MicroRNA Content to Complement First-of-its-Kind MicroRNA Filtering Capability in IPA 2
... The Brasseler USA™ Battery Packs contain ... age have a great impact upon battery ... is necessary. Any deviation from these recommendations ... are sensitive to heat. Any exposure of ...
Pneumatic High-speed Drill, Throttleless, 90k Rpm, Microaire Connector....
Pneumatic foot surgical oscillating saw, 24k cpm, available with various hose connector styles....
... Motor Module, without throttle (MicroAire hose connector). ... attachments., ,1050-100 model requires 10ft. ... MicroAire connector. Also requires 9100-000 Foot Control ... hose 9013-000, or existing hose with Linvatec/Hall ...
Medicine Products: