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Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
Date:9/26/2011

ween the two groups.

Compared to animals with normal cholesterol, the high-cholesterol animals treated with naproxen had lower blood flow to the heart, decreased levels of prostacyclin, and decreased levels of several proteins that promote cardiac cell survival. In addition, previous studies by the group showed that while naproxen helped increased blood flow in the hearts of animals with normal cholesterol, this effect was not seen in animals with high cholesterol.

Sellke says, "These results show that high blood cholesterol levels change the way naproxen affects the heart, and alters blood flow to the heart. This 'myocardial perfusion' may be one predictor of angina frequency and quality of life in patients with chronic ischemia. Thus, these findings may have important implications for cardiac patients taking NSAIDs."

First author Louis Chu, M.D., who worked with Sellke on the study, adds, "Our study indicates that physicians should be aware that cholesterol control may be especially important if patients are taking NSAID medications such as naproxen."

Sellke adds, "While the results of these animal experiments are interesting and may provide information regarding the effect of a high fat diet on the response to naproxen and other similar medications, one cannot make definitive statements on the effect of these medications on patients without first doing clinical studies."


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Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert  

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