Navigation Links
Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
Date:9/26/2011

PROVIDENCE, R.I. A new study from Rhode Island Hospital researchers suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. The study is published in the current issue of the journal Surgery.

NSAIDs are among the most widely-used drugs today for the treatment of post-operative pain, inflammatory conditions and fever. Despite that, the factors that affect their cardiovascular safety are not well understood and some studies suggest that there may be an increased incidence of cardiovascular complications such as heart attack or death.

This study, led by principal investigator Frank Sellke, M.D., chief of cardiothoracic surgery and research at Rhode Island Hospital, developed an animal model of hypercholesterolemia in swine to investigate the formation of collateral vessels and other effects in the heart, and the safety of NSAID and other medications.

Through their study, Sellke says, "We found that a high-cholesterol diet reduced blood flow to the heart muscle in our animal models with chronic heart disease when given daily naproxen. We also found reduced levels of prostacyclin, a compound that dilates blood vessels and prevents blood clots. These findings suggest that there may be a stronger risk of negative effects on the heart in patients who have high cholesterol levels and are taking NSAIDs as a form of pain or inflammation relief."

The researchers compared two groups within the animal model, one with a normal diet, and one group that received a diet high in cholesterol, and both groups received daily naproxen. The animals also underwent surgery to simulate coronary artery disease, which affects many human patients who take NSAIDs. Several differences were found between the two groups.

Compared to animals with normal cholesterol, the high-cholesterol animals treated with naproxen had lower blood flow to the heart, decreased levels of prostacyclin, and decreased levels of several proteins that promote cardiac cell survival. In addition, previous studies by the group showed that while naproxen helped increased blood flow in the hearts of animals with normal cholesterol, this effect was not seen in animals with high cholesterol.

Sellke says, "These results show that high blood cholesterol levels change the way naproxen affects the heart, and alters blood flow to the heart. This 'myocardial perfusion' may be one predictor of angina frequency and quality of life in patients with chronic ischemia. Thus, these findings may have important implications for cardiac patients taking NSAIDs."

First author Louis Chu, M.D., who worked with Sellke on the study, adds, "Our study indicates that physicians should be aware that cholesterol control may be especially important if patients are taking NSAID medications such as naproxen."

Sellke adds, "While the results of these animal experiments are interesting and may provide information regarding the effect of a high fat diet on the response to naproxen and other similar medications, one cannot make definitive statements on the effect of these medications on patients without first doing clinical studies."


'/>"/>

Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert  

Related medicine news :

1. Rhode Island Settlement Reflects Homeowner Liability for Serving Alcohol to Those Under 21, Says Providence Lawyer Mark Gemma
2. Rhode Island Hospital physician receives national award for research
3. Women & Infants launches Rhode Island Network for Pelvic Floor Disorders
4. Paper by Rhode Island Hospital physician selected among best of 2010 by JACR
5. Rhode Island Hospital fellow receives funding to support research in myocardial perfusion
6. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
7. Rhode Island Hospital study identifies fish oils impact on cognition and brain structure
8. Tishman Speyer Hosts Government, Union and Civic Leaders for Topping Out of Gotham Center Tower in Long Island City
9. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
10. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
11. Long Island Children's Orthodontist Announces Office Improvements And New Staff Member
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
(Date:2/20/2017)... ... ... The StayWell Company and VUCA Health announced today that ... behavior change and improve health literacy among patients. VUCA Health, which created and manages ... video capability at StayWell booth 3443 during HiMSS. , The VUCA library has ...
(Date:2/20/2017)... TX (PRWEB) , ... February 20, 2017 , ... ... is now offering a full range of emergency dental care at his office, ... and gums. When patients experience dental emergencies, they are at risk for serious ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain Department of Nursing ... by Amelia Joseph, Ph.D. Joseph was engaged by the college as a consultant to ... early 2016. After a nation-wide search, she was selected to head the department as ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... **FDAnews Free Webinar**, March 1, 2017 — 1:30 p.m. – 2:30 p.m. ... burden? Pay dividends in enhanced and predictable product performance? Streamline processes resulting ...
(Date:2/18/2017)... ... February 18, 2017 , ... ... Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX ... applications. Users can pick and choose from hand-crafted trend-setting designs with smooth ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , Feb. 20, 2017   Orion Health ... its Amadeus precision medicine platform to the ... currently manages over 110 million patient records globally. ... developing cloud-based, big data solutions built on modern, scalable ... Healthcare and Life Sciences. "The AWS Cloud gives healthcare ...
(Date:2/20/2017)... , Feb. 20, 2017 Research and Markets ... and Freezer Market Analysis and Trends - Product (RFID refrigerators and ... to 2025" report to their offering. ... The Global RFID Blood Refrigerator and ... 21.3% from 2015 to 2025. This industry report ...
(Date:2/20/2017)... Feb. 20, 2017   Alberty   ... Batavia, NY has announced a significant shift ... and wellness programs to servicing local Veteran Affairs Centers ... budgets and an increased need to secure cost effective ... to source locally for their goods & services. ...
Breaking Medicine Technology: