Navigation Links
Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
Date:9/26/2011

PROVIDENCE, R.I. A new study from Rhode Island Hospital researchers suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. The study is published in the current issue of the journal Surgery.

NSAIDs are among the most widely-used drugs today for the treatment of post-operative pain, inflammatory conditions and fever. Despite that, the factors that affect their cardiovascular safety are not well understood and some studies suggest that there may be an increased incidence of cardiovascular complications such as heart attack or death.

This study, led by principal investigator Frank Sellke, M.D., chief of cardiothoracic surgery and research at Rhode Island Hospital, developed an animal model of hypercholesterolemia in swine to investigate the formation of collateral vessels and other effects in the heart, and the safety of NSAID and other medications.

Through their study, Sellke says, "We found that a high-cholesterol diet reduced blood flow to the heart muscle in our animal models with chronic heart disease when given daily naproxen. We also found reduced levels of prostacyclin, a compound that dilates blood vessels and prevents blood clots. These findings suggest that there may be a stronger risk of negative effects on the heart in patients who have high cholesterol levels and are taking NSAIDs as a form of pain or inflammation relief."

The researchers compared two groups within the animal model, one with a normal diet, and one group that received a diet high in cholesterol, and both groups received daily naproxen. The animals also underwent surgery to simulate coronary artery disease, which affects many human patients who take NSAIDs. Several differences were found bet
'/>"/>

Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Rhode Island Settlement Reflects Homeowner Liability for Serving Alcohol to Those Under 21, Says Providence Lawyer Mark Gemma
2. Rhode Island Hospital physician receives national award for research
3. Women & Infants launches Rhode Island Network for Pelvic Floor Disorders
4. Paper by Rhode Island Hospital physician selected among best of 2010 by JACR
5. Rhode Island Hospital fellow receives funding to support research in myocardial perfusion
6. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
7. Rhode Island Hospital study identifies fish oils impact on cognition and brain structure
8. Tishman Speyer Hosts Government, Union and Civic Leaders for Topping Out of Gotham Center Tower in Long Island City
9. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
10. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
11. Long Island Children's Orthodontist Announces Office Improvements And New Staff Member
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
(Date:8/22/2014)... Buying a policy for different life insurance products can ... coverage types by insurers in the U.S. The Quotes Pros ... the public using its sortable tool at http://quotespros.com/life-insurance.html . ... is expected to promote the discounts and special offerings for ... The system is designed to help an adult locate a ...
(Date:8/22/2014)... 22, 2014 The regional economy is ... is on the grow again. The plant ... summer 2016 to boost production of the popular Highlander ... Indiana’s overall investment to $4 billion. This step allows ... providing additional flexibility to adjust its product mix to ...
(Date:8/22/2014)... August 22, 2014 As the ... http://www.injurybeacon.com/power-morcellator/ ) in uterine surgeries continues to grow, ... companies have decided to limit coverage of uterine ... Telegram, Blue Cross-Blue Shield of Massachusetts will no ... involve morcellation as of September 1, 2014. Other ...
(Date:8/22/2014)... Bcl-2-like protein 11 (BIM) deletion in advanced ... shorter progression free survival (PFS) in epidermal growth ... chemotherapy treated Asian patients. Also, BIM deletion independently ... , The BIM protein can activate the programmed ... in cells. BIM deletion has been detected in ...
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... developed by Dr. Sen and Dr. Samantha Pearson to ... glasses, contacts, and avoid corrective vision surgery by instead ... Shane Michaels, prompting an investigative review. , “There’s ... billions of dollars in revenue each year—it’s because people ...
Breaking Medicine News(10 mins):Health News:Principal Life Insurance Policies Now Quoted for Adults at Insurance Website Online 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 3Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 4Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2
... 17 Addus HomeCare Corporation announced today that it has filed ... Exchange Commission (SEC) relating to a proposed initial public offering of ... and the price range for the offering have not yet been ... be offered by Addus HomeCare Corporation. , ...
... ... (TRACK™) is the first validated, parent-administered asthma-control test for preschool-aged children , ... Wilmington, DE (PRWEB) July 17, ... simple questions to determine if their child,s breathing problems are not under control. AstraZeneca ...
... , , WASHINGTON, July 17 ... nurses today hailed passage of a key amendment in the ... bill this morning that would enable individual states to go ... , Introduced by Rep. Dennis ...
... Could be targets for new treatments, researchers say , FRIDAY, ... genetic variants associated with high blood pressure in black Americans ... treat this major risk factor for heart disease and stroke. ... of PLoS Genetics , is one of a series ...
... , Patient Advocates , Medicare Beneficiaries Visit ... Act, Oppose Additional Cuts to Oxygen Benefit , ... of Congress to support patient-focused reform of the Medicare home oxygen ... (NECA), a national advocacy organization representing patients with chronic obstructive pulmonary ...
... Mass., July 17 The Hanover Insurance Group (NYSE: THG ... availability of a new product offering that can extend homeowners coverage to ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20051031/NEM023LOGO ... is more important than ever as the population of people residing in ...
Cached Medicine News:Health News:Addus HomeCare Corporation Files Registration Statement 2Health News:New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age 2Health News:New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age 3Health News:New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age 4Health News:RNs Praise House Vote to Permit State Single-Payer Laws 2Health News:RNs Praise House Vote to Permit State Single-Payer Laws 3Health News:Five Hypertension Genes Found in Black Americans 2Health News:Five Hypertension Genes Found in Black Americans 3Health News:Home Oxygen Patients and Family Members Visit Capitol Hill to Ask Congress to Protect Medicare Home Oxygen Therapy Benefit 2Health News:The Hanover Launches New Insurance Option to Protect Family Members in Assisted Living Facilities 2Health News:The Hanover Launches New Insurance Option to Protect Family Members in Assisted Living Facilities 3
(Date:8/21/2014)... /CNW/ - Eisai Limited is pleased to support the Canadian ... book available in Canada . The comic ... educate children and their parents about epilepsy, the most common ... than 300,000 Canadians. Eisai is guided by a corporate philosophy ... the patient is central – there was a need within ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Equipment, Inc. for the third straight year, No. ... 500|5000, an exclusive ranking of the nation,s fastest-growing ... look at the most important segment of the ... Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and many ...
(Date:8/21/2014)...  Seventy-one percent of Americans believe the abuse of strong ... health and safety issue in the United States ... by Repass & Partners, a Cincinnati ... severity of the prescription medication abuse problem and the need ... health situation facing our country," Rex Repass , CEO ...
Breaking Medicine Technology:Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... Caremark (NYSE: CVS ) has been named ... by Reputation Institute, in partnership with Forbes Media. The ... RepTrak™ Pulse, a study that measures the 150 largest ... ) Of the companies included in ...
... -- American Oriental Bioengineering, Inc. (NYSE: AOB ) ... (the "NYSE") has notified the Company that it is not ... to timely file its Annual Report on Form 10-K with ... rules, when a Company does not comply with annual report ...
Cached Medicine Technology:CVS Caremark Ranks Among Top 25 Most Reputable Companies in America on Forbes List 2American Oriental Bioengineering Inc. Receives NYSE Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard 2
... of DOA Panel Test is ... in vitro test. It is ... substances in human urine specimens. ... in the point of care ...
... a qualitative immunoassay intended to ... usage of cocaine by detecting ... in human urine at a ... It is for health care,professional ...
The RapidBARBITURATE test is an immunochromatography based one step in vitro test. It is designed for qualitative determination of barbiturates and in human urine specimens above a cut-off level of 3...
... delivers performance, value and safety ... smaller laboratories. It's an affordable, ... small sample volume in both ... a wide operating range and ...
Medicine Products: