Navigation Links
Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
Date:9/26/2011

PROVIDENCE, R.I. A new study from Rhode Island Hospital researchers suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. The study is published in the current issue of the journal Surgery.

NSAIDs are among the most widely-used drugs today for the treatment of post-operative pain, inflammatory conditions and fever. Despite that, the factors that affect their cardiovascular safety are not well understood and some studies suggest that there may be an increased incidence of cardiovascular complications such as heart attack or death.

This study, led by principal investigator Frank Sellke, M.D., chief of cardiothoracic surgery and research at Rhode Island Hospital, developed an animal model of hypercholesterolemia in swine to investigate the formation of collateral vessels and other effects in the heart, and the safety of NSAID and other medications.

Through their study, Sellke says, "We found that a high-cholesterol diet reduced blood flow to the heart muscle in our animal models with chronic heart disease when given daily naproxen. We also found reduced levels of prostacyclin, a compound that dilates blood vessels and prevents blood clots. These findings suggest that there may be a stronger risk of negative effects on the heart in patients who have high cholesterol levels and are taking NSAIDs as a form of pain or inflammation relief."

The researchers compared two groups within the animal model, one with a normal diet, and one group that received a diet high in cholesterol, and both groups received daily naproxen. The animals also underwent surgery to simulate coronary artery disease, which affects many human patients who take NSAIDs. Several differences were found between the two groups.

Compared to animals with normal cholesterol, the high-cholesterol animals treated with naproxen had lower blood flow to the heart, decreased levels of prostacyclin, and decreased levels of several proteins that promote cardiac cell survival. In addition, previous studies by the group showed that while naproxen helped increased blood flow in the hearts of animals with normal cholesterol, this effect was not seen in animals with high cholesterol.

Sellke says, "These results show that high blood cholesterol levels change the way naproxen affects the heart, and alters blood flow to the heart. This 'myocardial perfusion' may be one predictor of angina frequency and quality of life in patients with chronic ischemia. Thus, these findings may have important implications for cardiac patients taking NSAIDs."

First author Louis Chu, M.D., who worked with Sellke on the study, adds, "Our study indicates that physicians should be aware that cholesterol control may be especially important if patients are taking NSAID medications such as naproxen."

Sellke adds, "While the results of these animal experiments are interesting and may provide information regarding the effect of a high fat diet on the response to naproxen and other similar medications, one cannot make definitive statements on the effect of these medications on patients without first doing clinical studies."


'/>"/>

Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert  

Related medicine news :

1. Rhode Island Settlement Reflects Homeowner Liability for Serving Alcohol to Those Under 21, Says Providence Lawyer Mark Gemma
2. Rhode Island Hospital physician receives national award for research
3. Women & Infants launches Rhode Island Network for Pelvic Floor Disorders
4. Paper by Rhode Island Hospital physician selected among best of 2010 by JACR
5. Rhode Island Hospital fellow receives funding to support research in myocardial perfusion
6. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
7. Rhode Island Hospital study identifies fish oils impact on cognition and brain structure
8. Tishman Speyer Hosts Government, Union and Civic Leaders for Topping Out of Gotham Center Tower in Long Island City
9. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
10. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
11. Long Island Children's Orthodontist Announces Office Improvements And New Staff Member
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
(Date:5/24/2016)... ... May 24, 2016 , ... ... of Jonathan (Jon) Otterstatter to its board of directors. Otterstatter is ... leader in the development of technological innovations that lead to broad-based healthcare solutions. ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... by 9.3 million people, or 10% over last year, according to data in ... under group policies was comparatively stable, with a slight decrease in risk-based groups ...
(Date:5/24/2016)... ... May 24, 2016 , ... Tuesday, May 24, Women's ... Yoga practice enhanced with Young Living Essential Oils, taught by Patti Dolan, RYT, ... Lake Orion location. Yoga Flow is 6:30pm - 7:15pm followed by a small intro ...
(Date:5/24/2016)... Pass, OR (PRWEB) , ... May 24, 2016 ... ... Kleyne welcomed Peggy Kinst, a wellness specialist for forty years and a trainer ... on the Sharon Kleyne Hour Radio Talk Show on May 16, 2016. , ...
(Date:5/24/2016)... ... May 24, 2016 , ... As reported by MassGeneral.org, on May ... transplant in the United States . The 64-year-old patient who received the transplant had ... could restore not only a natural appearance, but also urinary and sexual function for ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... the world , s first dual ... fistula intervention   OrbusNeich, a global company ... expanded its portfolio to include products to treat peripheral ... the company,s first entry devices for lower limb and ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 /PRNewswire/ ... primer stent de doble terapia del mundo, introduce ... fístula arteriovenosa. OrbusNeich, una compañía global ... cambian las vidas, ha expandido su cartera incluyendo ... catéteres balón JADE™ y Scoreflex™ PTA son los ...
(Date:5/24/2016)... May 24, 2016 ... , la première endoprothèse à double ... à l,intervention portant sur les membres inférieurs ... OrbusNeich, entreprise mondiale spécialisée dans la ... la vie, a élargi son portefeuille pour ...
Breaking Medicine Technology: