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Rhode Island Hospital awarded $11 million, 5-year renewal
Date:8/31/2009

lps to solidify our role of supporting the Rhode Island economy by increasing the research and biotechnology being done locally."

Under the leadership of principal investigator Douglas Hixson, PhD, the center received its first grant in 2003. Hixson says, "Over the past five years we have established an infrastructure and the technology to support basic research in the area of gastrointestinal cancer and to engage investigators in developing new research initiatives centered around the role of adult stem cells in the genesis of cancer." He further notes, "This year we also received a $500,000 economic stimulus fund grant that allowed our proteomics core to purchase a state-of-the art imaging mass spectrometer. By allowing investigators to identify proteins differentially expressed in malignant and normal cells by directly scanning tissue sections, this exciting new technology will accelerate the identification of biomarkers by directly linking the fields of proteomics and molecular pathology."

"This award will enable these investigators to continue to build their capacity to perform state-of-the-art research in specific cancers, such as in gastrointestinal tumors," said NCRR Director Barbara Alving, MD. "The center will also provide excellent opportunities to train new generations of biomedical researchers."

Since its opening in 2003, the center has already made discoveries that have broadened knowledge of different types of cancer. Hixson explains, "We've identified a new mode of transmitting signals regulating the growth and spread of cancer, a new gene that determines sensitivity to anti cancer drugs, another gene elevated by acid reflux that increases the risk of esophageal cancer and two novel tumor suppressor genes whose loss elevates the risk of stomach cancer.

"The renewal of our grant provides us with an outstanding potential for groundbreaking research in our center," he comments. Over the next five years, the center w
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Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert

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