Navigation Links
Rheumatoid arthritis signaling protein reverses Alzheimer's disease in mouse model
Date:8/22/2010

Tampa, FL (August 23, 2010) -- A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer's disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study by the University of South Florida reports. Researchers found that the protein, GM-CSF, likely stimulates the body's natural scavenger cells to attack and remove Alzheimer's amyloid deposits in the brain.

The study appears online today in the Journal of Alzheimer's Disease.

People with rheumatoid arthritis, a chronic disease leading to inflammation of joints and surrounding tissue, are less likely than those without arthritis to develop Alzheimer's. While it was commonly assumed that non-steroidal anti-inflammatory drugs may help prevent onset and progression of Alzheimer's disease, recent NSAID clinical trials proved unsuccessful for patients with Alzheimer's.

The USF researchers are among the first to look at what effect innate immunity gone awry in rheumatoid arthritis may play in protecting against Alzheimer's disease.

"Our findings provide a compelling explanation for why rheumatoid arthritis is a negative risk factor for Alzheimer's disease," said principal investigator Huntington Potter, PhD, professor of molecular medicine at the USF Health Byrd Alzheimer's Institute and director of the Florida Alzheimer's Disease Research Center.

"Moreover, the recombinant human form of GM-CSF (Leukine) is already approved by the FDA and has been used for years to treat certain cancer patients who need to generate more immune cells," Dr. Potter said. "Our study, along with the drug's track record for safety, suggests Leukine should be tested in humans as a potential treatment for Alzheimer's disease."

The researchers analyzed three rheumatoid arthritis growth factors in mouse models and identified the signaling protein GM-CSF as the most promising fo
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New way of classifying rheumatoid arthritis aimed at identifying the disease earlier
2. Could Drinking Help Thwart Rheumatoid Arthritis?
3. Majority of Ontarians suffering from rheumatoid arthritis not receiving needed speciality care
4. New Approach to Rheumatoid Arthritis
5. Sex lives of patients are negatively affected by rheumatoid arthritis and SLE
6. Women who consume large amounts of tea have increased risk of rheumatoid arthritis
7. Partners grieve rheumatoid arthritis diagnosis as much as patients
8. Stomach Bacteria Might Trigger Rheumatoid Arthritis
9. Almost three quarters of women with rheumatoid arthritis worldwide suffer pain daily
10. Shoulder arthritis? What patients need to know before treatment
11. Knee arthritis? Flexible options can help keep you active
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rheumatoid arthritis signaling protein reverses Alzheimer's disease in mouse model
(Date:10/20/2014)... 2014 hc1.com today announced the ... solution that enables healthcare organizations of all sizes ... customer relationship management (“CRM”) solution. , Designed from ... of the healthcare industry, the hc1 Healthcare Relationship ... patients by combining healthcare CRM, HIPAA-compliant collaboration, and ...
(Date:10/20/2014)... Ohio (PRWEB) October 20, 2014 Principle ... years, takes pride in manufacturing top-of-the-line absorbent products. ... image of its most popular brand, Tranquility® Premium Protection ... created a new website, gave its packaging a new ... bring the brand message to the public. , The ...
(Date:10/20/2014)... Succeed is proud to announce that they ranked ... the Every Body Walk! campaign by Kaiser Permanente. ... encourages workers to be more active outside of the workplace. ... at the end of September, was a friendly competition between ... Participating companies gave their staff pedometers and each day, ...
(Date:10/20/2014)... 2014 Unveiled at the Sept. 18 board ... conservatively estimates member hospital ROI on membership dues at 12.5. ... Center provides $12.50 in value to member hospitals. The calculation ... Member Dues)/Member Dues. , “This is the first time ... we think the methodology is really sound,” said Bill ...
(Date:10/20/2014)... Silver Spring, Maryland, USA (PRWEB) October 20, 2014 ... readers or to track interventions? Here comes a wonderful ... leading mobile app development company helped its ... track Intervention more efficiently. The app is designed for ... iPad, and iPod touch. This app is optimized for ...
Breaking Medicine News(10 mins):Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3
... Sam Smith as the new Chief Executive Officer of the international ... the International Board of Directors on Tuesday. , ... ... the unanimous confirmation of Sam Smith as the new Chief Executive ...
... Healthcare IT provider grows its operations in the Middle East , ... Systems Corporation (NYSE: PER ) ( www.perotsystems.com ) today ... to manage the pilot deployment of VistA - an open source ... a clinic in the capital, Amman. , ...
... EMPHYSEMA AT RISK FOR OSTEOPOROSIS , New research shows ... includes emphysema and chronic bronchitis, may also be at ... scans and pulmonary function tests on 65 male patients ... compare vertebral bone density with percentage of low attenuation ...
... D. England, MD, Professor and Chairman of Neurology at ... is the principal investigator of two studies recommending ... nerve disorder that to this time had few evidence-based ... two separate papers in the December 3, 2008 online ...
... The American Society of Hematology (ASH) will host its ... Marriott on Thursday, December 4, 2008, beginning at 8:00 ... hematology, the biological sciences, and medical research, is held ... year, students will have the opportunity to explore research ...
... N.J., Dec. 3 MedQuist Inc. (Nasdaq: MEDQ ... world, is pleased to announce the positive resolution of several ... Resolution of the DOJ Investigation , ... an administrative HIPAA subpoena for documents from the United States ...
Cached Medicine News:Health News:New CEO Takes Helm at Mercy Ships 2Health News:New CEO Takes Helm at Mercy Ships 3Health News:Perot Systems Awarded Contract to Implement Health Information System in Kingdom of Jordan 2Health News:Perot Systems Awarded Contract to Implement Health Information System in Kingdom of Jordan 3Health News:Journal CHEST: December highlighted studies 2Health News:LSUHSC's England leads development of new testing guidelines for common nerve disorder 2Health News:ASH Holds a Special Symposium to Interest High School Students in Biomedical Research 2Health News:MedQuist Announces Resolution of the DOJ Investigation and Dismissal of Shareholder Lawsuits 2Health News:MedQuist Announces Resolution of the DOJ Investigation and Dismissal of Shareholder Lawsuits 3Health News:MedQuist Announces Resolution of the DOJ Investigation and Dismissal of Shareholder Lawsuits 4Health News:MedQuist Announces Resolution of the DOJ Investigation and Dismissal of Shareholder Lawsuits 5Health News:MedQuist Announces Resolution of the DOJ Investigation and Dismissal of Shareholder Lawsuits 6
(Date:10/20/2014)... , 20 de octubre de 2014  PneumRx, ... campo de la pulmonología intervencional, anunció hoy la ... casi 3 meses antes de lo programado. El Estudio ... de dispositivo de investigación (IDE) aprobada por la ... sistema de espiral de reducción de volumen pulmonar ...
(Date:10/20/2014)... BRIDGEWATER, N.J. , Oct. 20, 2014 ... delivery technology designed for patients with Type 2 diabetes, ... Health Supply Chain Excellence Award. The award was presented ... Conference in Columbus, Ohio . ... recipients are judged across a variety of metrics specifically ...
(Date:10/20/2014)... Oct. 20, 2014 Lpath, Inc. (NASDAQ: ... bioactive lipid-targeted therapeutics, received official notification from the European ... another key patent supporting its iSONEP™ and ASONEP™ ... European patent No. 2087002, claims compositions of matter ... two lead compounds, iSONEP and ASONEP. Sonepcizumab is ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 2Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 4
Antiseptic - Antibacterial Sudsing Cleanser...
... This requiring no water for ... hand hygiene to physically clean ... is either not an option ... allows you to return to ...
BETASEPT® Scrub 4% is for surgical handscrubbing, healthcare personnel hand-washing, preoperative patient prepping and general skin degerming....
... Scrub Care® Brand soaps, emulsions, washes ... ultimate in healthy skin care, helping ... skin healthy and soft even with ... not contain petroleum-based substances that can ...
Medicine Products: