Navigation Links
Rheumatoid arthritis signaling protein reverses Alzheimer's disease in mouse model
Date:8/22/2010

Tampa, FL (August 23, 2010) -- A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer's disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study by the University of South Florida reports. Researchers found that the protein, GM-CSF, likely stimulates the body's natural scavenger cells to attack and remove Alzheimer's amyloid deposits in the brain.

The study appears online today in the Journal of Alzheimer's Disease.

People with rheumatoid arthritis, a chronic disease leading to inflammation of joints and surrounding tissue, are less likely than those without arthritis to develop Alzheimer's. While it was commonly assumed that non-steroidal anti-inflammatory drugs may help prevent onset and progression of Alzheimer's disease, recent NSAID clinical trials proved unsuccessful for patients with Alzheimer's.

The USF researchers are among the first to look at what effect innate immunity gone awry in rheumatoid arthritis may play in protecting against Alzheimer's disease.

"Our findings provide a compelling explanation for why rheumatoid arthritis is a negative risk factor for Alzheimer's disease," said principal investigator Huntington Potter, PhD, professor of molecular medicine at the USF Health Byrd Alzheimer's Institute and director of the Florida Alzheimer's Disease Research Center.

"Moreover, the recombinant human form of GM-CSF (Leukine) is already approved by the FDA and has been used for years to treat certain cancer patients who need to generate more immune cells," Dr. Potter said. "Our study, along with the drug's track record for safety, suggests Leukine should be tested in humans as a potential treatment for Alzheimer's disease."

The researchers analyzed three rheumatoid arthritis growth factors in mouse models and identified the signaling protein GM-CSF as the most promising for potential protective benefit against Alzheimer's disease. Then, they peripherally injected GM-CSF into two groups of mice those genetically altered to develop memory problems mimicking Alzheimer's disease and normal, aged mice. Behavioral tests confirmed the Alzheimer's mice were exhibiting signs of memory impairment at age 12 months. Another two control groups of mice the Alzheimer's mice and normal mice were administered saline (placebo).

After the 10th day of injections, all the mice began a series of behavioral testing. At the end of the 20-day study, the cognitively impaired mice treated with GM-CSF performed substantially better on tests measuring their working memory and learning. In fact, their memories were similar to normal aged mice without dementia. Even the normal mice treated with GM-CSF performed slightly better than their untreated peers. The Alzheimer's mice administered saline continued to do poorly on the tests.

"We were pretty amazed that the treatment completely reversed cognitive impairment in 20 days," said Tim Boyd, PhD, who, together with Steven Bennett, PhD, is a study lead author.

In addition, the brains of GM-CSF-treated Alzheimer's mice showed more than a 50-percent decrease in beta amyloid, a substance forming the sticky clumps of plaques that are a hallmark of Alzheimer's disease. This reduction in Alzheimer's plaques and associated restoration of memory was accompanied by more immune cells known as microglia in the brain. Microglia are like the body's natural garbage collection cells that rush to damaged or inflamed areas to get rid of toxic substances.

The researchers suggest that GM-CSF boosted during the immune system overdrive of rheumatoid arthritis helps harness the beneficial properties of inflammation in the brain. The protein may do this by recruiting more microglia from the peripheral blood into the brain to remove Alzheimer's plaques, Dr. Potter said. An apparent increase in neural cell connections in the brains of the GM-CSF-treated mice may also help explain GM-CSF's association with improving memory decline in Alzheimer's disease, the researchers said.

The USF Health Byrd Alzheimer's Institute plans to begin a pilot clinical trial later this year investigating GM-CSF (Leukine) in patients with mild or moderate Alzheimer's disease.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert  

Related medicine news :

1. New way of classifying rheumatoid arthritis aimed at identifying the disease earlier
2. Could Drinking Help Thwart Rheumatoid Arthritis?
3. Majority of Ontarians suffering from rheumatoid arthritis not receiving needed speciality care
4. New Approach to Rheumatoid Arthritis
5. Sex lives of patients are negatively affected by rheumatoid arthritis and SLE
6. Women who consume large amounts of tea have increased risk of rheumatoid arthritis
7. Partners grieve rheumatoid arthritis diagnosis as much as patients
8. Stomach Bacteria Might Trigger Rheumatoid Arthritis
9. Almost three quarters of women with rheumatoid arthritis worldwide suffer pain daily
10. Shoulder arthritis? What patients need to know before treatment
11. Knee arthritis? Flexible options can help keep you active
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rheumatoid arthritis signaling protein reverses Alzheimer's disease in mouse model
(Date:2/10/2016)... ... February 10, 2016 , ... ... Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions - Time: 7:00pm ... 7:00pm – 10:00pm | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , ...
(Date:2/10/2016)... DC (PRWEB) , ... February 10, 2016 , ... Anxiety ... level since the start of Medicare Part D a decade ago, according to ... comments from older adults on how they are coping with rapidly rising costs. ...
(Date:2/10/2016)... ... February 09, 2016 , ... According to a recent article ... in the number of patients under the age of 30. According to Southern California ... their offices, and may indicate an overall shift in the rapidly growing social acceptance ...
(Date:2/9/2016)... ... February 09, 2016 , ... Center for ... are diagnosed with autism spectrum disorder (ASD). Beginning Jan. 1, 2016, Medicaid is ... behavior analysis (ABA) is key to providing effective treatment for individuals with ASD. ...
(Date:2/9/2016)... ... 2016 , ... A new study from the Workers Compensation ... for a variety of medical services in Illinois as of 2015. , ... Schedule Rates in Illinois, are professional medical services, hospital outpatient and ambulatory ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 The new report "Global Blood Monitoring ... Acuity Business Research & Consulting group reveals that global market for ... million in 2014 and expected to grow to US$ 24,830.1 million ... North America , Europe ... , Middle-East and Africa ...
(Date:2/9/2016)... BRUNSWICK, N.J. , Feb. 9, 2016  Johnson ... the RBC Capital Markets Global Healthcare Conference on Tuesday, ... York City.  Dominic Caruso , Vice President, Finance ... Worldwide Chairman, Consumer will represent the Company in a ... www.investor.jnj.com . --> www.investor.jnj.com . ...
(Date:2/9/2016)... , Feb. 9, 2016  Bluestar Silicones will promote ... line for long-term implant applications and announce certification ... & Manufacturing (MD&M) West Conference (Booth #1759), February ... --> --> Available in ... LSRs offer outstanding physical properties enabling our customers ...
Breaking Medicine Technology: