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Rheumatoid arthritis factors equal to cardiovascular factors in risk of severe cardiovascular events
Date:6/13/2008

utcomes in RA along with appropriate management and treatment options for the future."

All data were taken from the Consortium of Rheumatology Researchers of North America, Inc. (CORRONA) independent registry, the largest physician-based RA registry in the US, which carries information on over 15,000 patients with RA and other rheumatic conditions. Records for patients who had made at least two visits to healthcare facilities were selected and information about CVD risk factors, with RA disease factors drawn from baseline questionnaires.

CVD outcomes included MI, stroke and transient ischemic attack, reported and then confirmed by the treating rheumatologist. CVD risk factors included a history of coronary artery disease or MI, diabetes, hypertension, family history of premature MI, body mass index, dyslipidemia (assessed as use of a lipid-lowering agent), non-Caucasian ethnicity, and current tobacco use.

RA disease factors included duration of RA, rheumatoid factor status, HAQ, CDAI, subcutaneous nodules, Sjogrens (an autoimmune condition associated with arthritis), tender joint count, swollen joint count, and total joint replacements. These variables were assessed as predictors of CVD outcomes in separate Cox regression models, with age and gender included in both. Finally, the discriminatory value of these variables was assessed by calculating the area under the receiver operating characteristic curve (C statistic) in logistic regression.


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Contact: Rory Berrie / Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-077-892-70392
European League Against Rheumatism
Source:Eurekalert

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