Navigation Links
Rheumatoid arthritis and heart disease: Mayo Clinic studies shed light on dangerous connection
Date:10/26/2013

SAN DIEGO -- People with rheumatoid arthritis and other chronic inflammatory conditions are at higher risk of heart disease. Who is in the most danger, why and how best to prevent and detect cardiovascular complications are important questions for physicians and researchers. Mayo Clinic studies presented at the American College of Rheumatology annual meeting shed new light on this connection, in part by revealing factors that seem to put some rheumatoid arthritis patients in greater jeopardy of heart problems: early menopause, more severe rheumatoid arthritis and immunity to a common virus, cytomegalovirus, among others.

MULTIMEDIA ALERT: Video of Dr. Matteson is available for download from the Mayo Clinic News Network.

In one study, Mayo researchers discovered that patients whose rheumatoid arthritis is more severe are likelier to have heart problems. That becomes true soon after rheumatoid arthritis strikes, making early treatment of rheumatoid arthritis important, says co-author Eric Matteson, M.D., chair of rheumatology at Mayo Clinic in Rochester, Minn.

"One thing that we learned in particular in this study is that the high disease burden on the joints in the first year of disease already is a very strong predictor of cardiovascular disease subsequently, and that seems to be mitigated as time goes on if the disease burden can be reduced too," Dr. Matteson says.

In other research, a Mayo team looked at a common virus called cytomegalovirus, a bug many people get and do not even know they have. They found correlations between rheumatoid arthritis patients' immune response to the virus and the development of myocardial disease.

If it turns out that there is this relationship, then it may be that one way to spot patients who are at higher risk for heart disease would be an immune profile or biomarkers related to the cytomegalovirus and its associated immune activation signaling," says Dr. Matteson, a co-author.

Another study found that women with rheumatoid arthritis and early menopause -- menopause before age 45 -- also seem to be at higher risk of heart disease. About two-thirds of patients with rheumatoid arthritis are women, and researchers have long studied possible hormonal influences on development of the disease, Dr. Matteson says.

"This study shows the complex relationship between rheumatoid arthritis, hormones and heart disease," says Dr. Matteson, the senior author. "We also found patients who have had multiple children, especially seven or more, are at higher risk of cardiovascular disease compared with women who have menopause at a normal age or have fewer children."

Other Mayo Clinic studies found:

  • A higher incidence of the heart rhythm disorder, prolonged QT interval, in rheumatoid arthritis patients, particularly those who had a higher "sed rate" -- a blood test that can reveal inflammatory activity when their rheumatoid arthritis was diagnosed.

  • Rheumatoid arthritis patients are likelier to develop a high uric acid level, a condition called hyperuricemia, and that is a significant predictor of peripheral arterial disease, but doesn't appear to be one for cardiovascular disease.

  • Multiple risk factors for heart disease were spotted in patients when they were diagnosed with giant cell arteritis, inflammation of the lining of the arteries. However, giant cell arteritis patients do not seem to be at higher risk of acute coronary syndrome, a condition whose symptoms mirror those of a heart attack.


'/>"/>

Contact: Sharon Theimer
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
3. Gastro Woes Often Strike Rheumatoid Arthritis Patients
4. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
5. Rising Obesity Rates Might Mean More Rheumatoid Arthritis
6. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
7. Scientists identify new target to battle rheumatoid arthritis
8. Mayo Clinic: Standard heart disease risk tools underrate danger in rheumatoid arthritis
9. Early menopause predicts a milder form of rheumatoid arthritis
10. Smoking negatively affects response to anti-TNF treatment in patients with rheumatoid arthritis
11. Menopausal Age May Affect Rheumatoid Arthritis Severity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... 26, 2017 , ... New patients with missing teeth in Fitchburg, ... a referral. Dr. Cotey is a trusted dentist who has placed many dental implants ... Patients with missing teeth in Fitchburg, WI, are encouraged to find out if they ...
(Date:6/25/2017)... ... June 24, 2017 , ... Create a feel-good lyric music video in Final Cut Pro X ... the timeline and write in the lyrics to any song. ProLyric flies in the text ... of the text can be added modularly for optimal control. ProLyric makes editing any music ...
(Date:6/25/2017)... ... 25, 2017 , ... An increase in wetter weather in the Northern California ... with that; a humdinger of an allergy season. A relief from drought conditions is ... misery-causing grass and weed pollen. , “Our patients have been reporting the typical ...
(Date:6/25/2017)... ... ... With a heatwave currently bearing down on Northern California pushing temperatures to the maximum, many ... is easy with laser hair removal. , The process of summer waxing and constantly ... all you want to do is get out, dive in and cool off. There is ...
(Date:6/24/2017)... , ... June 24, 2017 , ... ... offering genetic testing for medications in select Florida and Texas doctors' offices and ... , This new application of genetic testing recognizes the role genes play in ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... June 7, 2017 Endo International plc (NASDAQ: ... 2017, the Hon. Joseph R. Goodwin , U.S. ... West Virginia , entered a case management ... Repair System Products Liability Litigation (the "MDL") that includes ... to provide expert disclosures on specific causation within one ...
(Date:6/5/2017)... 2017 The Cincinnati location ... Inc. (NYSE: DPLO), has been awarded a Top Workplaces ... Results are based on an employee survey administered by ... workplace improvement. The survey measures several aspects of workplace culture, ... ...
Breaking Medicine Technology: