Navigation Links
Rewiring the serotonin system
Date:2/13/2013

An interdisciplinary team of researchers from the University of Texas Medical Branch at Galveston and the University of Houston has found a new way to influence the vital serotonin signaling system possibly leading to more effective medications with fewer side effects.

Scientists have linked malfunctions in serotonin signaling to a wide range of health issues, everything from depression and addictions to epilepsy and obesity and eating disorders. Much of their attention has focused on complex proteins called serotonin receptors, which are located in the cell membrane. Each receptor has a so-called "active site" specially suited to bond with a serotonin molecule; when that bond is formed, the receptor changes shape, transmitting a signal to the cell's interior.

Traditional drug discovery efforts target interactions that take place at such active sites. But a receptor's behavior can also be changed by additional proteins that bind to the receptor at locations quite distant (in molecular terms) from the active site, in a process called "allosteric regulation" the mechanism examined by the UTMB-UH team for one specific and highly significant kind of serotonin receptor, designated the 5-HT2C.

"This is a whole new way of thinking about this system, targeting these interactions," said UTMB professor Kathryn Cunningham, senior author of a paper on the research now online in the Journal of Neuroscience. "Basically, we've created a new series of molecules and validated that we can use them to change the way the receptor functions both in vitro and in vivo, through an allosteric effect."

The UTMB-UH group's approach centers on the natural interaction between the 5-HT2C receptor, serotonin, and another molecule called PTEN. Like serotonin, PTEN controls 5-HT2C receptor function; because it does so at a location distant from the active site, it's possible and in fact common for a receptor to bind to serotonin and PTEN simulta
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Rewiring DNA circuitry could help treat asthma
2. IU, Regenstrief automated system aims to improve child health
3. Scientists tailor cell surface targeting system to hit organelle ZIP codes
4. Physicians call for improvements to countrys public health system to protect US residents
5. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
6. Is it time for regional cardiovascular emergency care systems across the US?
7. How does the immune system fight off threats to the brain? New research yields fresh insight
8. Decision support system translates into high percentage of positive chest CT examinations
9. Pleasure eating triggers bodys reward system and may stimulate overeating
10. Block its recycling system, and cancer kicks the can, according to new Penn study
11. OHSU study: Misdiagnosis of MS is costing health system millions per year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Plainsboro, NJ (PRWEB) January 22, 2015 ... advocate and keynote speaker at the upcoming 32nd ... by ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , ... breast would have gone undetected if she had not ...
(Date:1/22/2015)... Weddingshe.com has added many trendy Champagne wedding dresses ... in the past three years. Today, the business announces a ... to the sales manager of the company, this is on ... This point can be reflected on the discounted wedding dresses ...
(Date:1/22/2015)... Payday lending practices in four southern states ... distress to the states that permit them, according to ... on Race and Wealth. , While they generate hundreds ... at the same time substantially depress economic activity, according ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 JJsHouse.com is a ... dresses. Today, the business announces its latest collection of ... , “The most important issue is the wedding dress on ... thing in a woman’s life. Every bride wants to find ...
(Date:1/22/2015)... 22, 2015 Step into a macabre ... Science Museum of Virginia. Wicked Plants, the Museum’s latest ... unearths 75 poisonous, carnivorous and diabolical plants inside of ... to uncover the biochemical, physical and neurological processes between ...
Breaking Medicine News(10 mins):Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... According to a recent survey, it has been observed that ... fasciitis. Plantar fasciitis is an inflammation of the band of ... the toes and the heel.// It causes excruciating pain first ... but it eases off once you have been on the ...
... to a recent survey there is not enough proof or ... worthwhile offering to all men. While the prostate specific antigen ... how useful the test really is. The US Preventive Services ... done on PSA and finds that there is insufficient evidence ...
... of scan are better than one when it comes ... cavity. Positron emission tomography (PET) scanning is useful// for ... (CT) is good for imaging anatomical detail. Researchers at ... two detects ovarian cancer spread better than using PET ...
... cystitis depends upon how their condition is diagnosed according ... the bladder which leads to frequent urination,// incomplete emptying ... It's common among women and can greatly impair their ... University of Bergen, Norway, describes a new approach to ...
... it is observed that a molecular marker is linked to ... increasing emphasis on looking for molecules// specific to that cancer ... Scientists at New York University now report on a molecular ... melanoma, the most serious form of skin cancer. ...
... been an effective utility tool to the field of ... important decisions about their treatment. The days when doctors ... Patients today expect to participate in the decision-making process. ... gives conflicting messages and new research comes up all ...
Cached Medicine News:
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
(Date:1/22/2015)... 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the ... therapies for cardiovascular disease and overall health is pleased to ... 2014 and its outlook for 2015 from the CEO, Mr. ... We would like to take this opportunity to share ...
(Date:1/22/2015)... Jan. 22, 2015 Increasing sophistication among enterprise buyers ... localization purchasing in 2015, says Moravia CMO, ... recent study by market research firm Common Sense Advisory, ... for their translation and localization needs. "From a language ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... the release of the new Patient-Centered Medical Home ... dependable roadmap to NCQA 2011 PCMH recognition , ... criteria. The release of the Toolkit complements the ... patient-centered care model, and underscores SuccessEHS,s continued commitment to ...
... Dec. 15, 2011  Each winter Jack Frost struts through ... those tough enough to brave his whistling winds. His ... The secret to ward off Jack,s mighty drying winds? ... a clinically proven alpha-hydroxy acid that gently exfoliates and ...
Cached Medicine Technology:SuccessEHS Releases Patient-Centered Medical Home (PCMH) Toolkit 2SuccessEHS Releases Patient-Centered Medical Home (PCMH) Toolkit 3SuccessEHS Releases Patient-Centered Medical Home (PCMH) Toolkit 4A Secret to Ward Off Jack Frost's Drying Effect on Your Skin: The AmLactin® Family of Moisturizers 2A Secret to Ward Off Jack Frost's Drying Effect on Your Skin: The AmLactin® Family of Moisturizers 3
Streck Cytometry Sheath fluid is a ready-to-use, balanced isotonic solution for use on flow cytometers. It is packaged in a 20 liter Cubitainer, and offers a two-year shelf life....
Streck-T-Pack is specially designed for use on Coulter® Counter T Series instruments. Each convenient pack includes diluent, lysing agent and enzymatic cleanser. The shelf life is 18 months from ...
Streck-ONYX-Pack is specially designed for use on Coulter® ONYX Series instruments. Each pack contains diluent and lysing agent. The shelf life is one year from date of manufacture....
... A lytic reagent ... quantitative determination of hemoglobin ... Streck-Lysing Agent IIIA is ... on the Abbott CELL-DYN® ...
Medicine Products: