Navigation Links
Rewiring DNA circuitry could help treat asthma
Date:7/5/2012

Reprogramming asthma-promoting immune cells in mice diminishes airway damage and inflammation, and could potentially lead to new treatments for people with asthma, researchers have found.

The researchers were able to reprogram the asthma-promoting cells (called Th2 (T-helper 2) cells) after identifying an enzyme that modifies the DNA of these cells. The enzyme could be a target for the development of new treatments for chronic inflammatory diseases, in particular allergic asthma, caused by an excess of Th2 cells.

Walter and Eliza Hall Institute researcher Dr Rhys Allan led the research while working at Institut Curie, Paris. The research team from Institut Curie, National Centre for Scientific Research (CNRS), France, National Institute of Health and Medical Research (INSERM), France, and Montpellier Cancer Research Institute published the study today in the journal Nature.

Dr Allan said the research team discovered that the enzyme Suv39h1 could switch off genes to control the function of Th2 cells, which are key to the allergic response.

"Th2 cells have an important function in the immune response, but they also play a significant role in diseases such as allergic asthma," Dr Allan said. "People with asthma have too many Th2 cells, which produce chemical signals that inflame and damage the upper airways. In this study, we discovered that the Suv39h1 enzyme plays a critical role in programming these asthma-promoting cells, making it a potential target for new therapies to treat asthma."

More than two million Australians have asthma approximately one in 10 people and the disease is even more common among Indigenous Australians. The prevalence of asthma in children in Australia is among the highest in the world. Dr Allan said the Suv39h1 enzyme was part of the 'epigenetic circuitry' of Th2 cells.

"Epigenetics refers to changes or modifications in the DNA that alter how genes are switched on and off, without changing the fundamental DNA sequence. Suv39h1 effectively 'tags' the DNA to tell the cells which genes they need to switch on or off to promote an allergic response."

Using agents that inhibit Suv39h1 could destabilise Th2 cells in people who have an excess of these asthma-promoting cells so they no longer cause inflammation, Dr Allan said.

"We had the idea that erasing these epigenetic tags could 'short-circuit' the asthma-promoting Th2 cells and diminish the inflammatory immune response. And, in fact, in mouse models of allergic asthma, blocking this pathway with an inhibitory compound did reduce allergy-related airway damage. Ultimately, our results have identified a potential target for therapeutic intervention in asthma and potentially other Th2-mediated inflammatory diseases, which could improve outcomes for patients," Dr Allan said.

Dr Allan is continuing to study the epigenetic circuitry of asthma-promoting immune cells in the institute's Molecular Immunology division, with funding from the National Health and Medical Research Council of Australia (NHMRC).


'/>"/>

Contact: Liz Williams
williams@wehi.edu.au
61-405-279-095
Walter and Eliza Hall Institute
Source:Eurekalert

Related medicine news :

1. Charting autisms neural circuitry
2. A better way to test new treatments? Approach could help patients and give useful results
3. The US Drug Watchdog Now Warns Time Could Run Out to Get Women Yaz or Yasmin Birth Control Pill Users Identified if they Suffered a Heart Attack Stroke or a Embolism
4. Dr. Davis Announces Some Diagnoses of ADHD May be Misinterpreted Visual Problems: Could Be Treated with Vision Therapy
5. New technique could reduce number of animals needed to test chemical safety
6. The US Drug Watchdog Now Offers To Help All Recipients Of Recalled DePuy ASR Hip Implant Get To The Best Attorneys Because Time Could Run Out To Get Them Identified
7. Menopausal women could work out their hot flashes
8. EVINCI results could lead to 75 percent reduction of invasive procedures for patients with suspected CAD
9. Victim’s Rights to Recover for Actos Bladder Cancer Could Expire Soon
10. Delaying ADHD Meds Could Hurt Kids Math Scores
11. Could Fertility Drugs Make Kids Shorter?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... ... Dr. Ronald E. Hawkins, vice president for academic affairs ... Bell, DO, MBA, HPF, FACOEP-dist., FACEP, as the new dean of Liberty ... to Liberty from the Ohio University Heritage College of Osteopathic Medicine (OU-HCOM), where ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: ... ’s true account of his paramedic experiences. Schanssema describes the tragedies he saw, as ... attempts to overcome them. , Schanssema, initially unsure of the career path he wanted ...
(Date:2/24/2017)... ... , ... Indiana Fiber Network (IFN) President and CEO Kelly C. Dyer recently ... as the Chairman of the Management Committee when IFN was originally formed in 2002 ... of investor/owners and development of the business plan. He became the first paid ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the most ... Jensie Gran Fondo of Marin. For the second year in a row, cyclists ... sunscreen. , “We are thrilled to provide our safe, non-toxic sunscreen to over ...
(Date:2/23/2017)... ... February 23, 2017 , ... The American Cleft Palate-Craniofacial Association (ACPA) is pleased ... KLS is a longtime supporter of the event. , "We are pleased that KLS ... Dr. Bob Havlik, 2017 ACPA President. "KLS Martin has a long track record of ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Feb. 24, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the Cowen and Company 37 ... Marriott Copley Place on Tuesday, March 7, 2017 at ... webcast of the presentation can be accessed at ... following the conference via Zimmer Biomet,s Investor Relations website ...
(Date:2/24/2017)... , Feb. 24, 2017  In conjunction with ... 2016 financial results press release, you are invited to ... live over the internet on Tuesday, March 14, 2017 ... A live audio webcast of the presentation ... www.durect.com and clicking "Investor Relations."  If you are ...
(Date:2/24/2017)... 24. Februar 2017 ITL Limited, ( ... Gesundheitsbereiches, ist erfreut, für das zum 31. Dezember ... Vorjahreszeitraum exzellente Ergebnisse vorlegen zu können. Eine vollständige ... Wachstum" finden Sie hier . ... Steuern 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
Breaking Medicine Technology: