Navigation Links
Revolutionary techniques could help harness patients' own immune cells to fight disease
Date:1/3/2013

The human body contains immune cells programmed to fight cancer and viral infections, but they often have short lifespans and are not numerous enough to overcome attacks by particularly aggressive malignancies or invasions. Now researchers reporting in two separate papers in the January 4th issue of the Cell Press journal Cell Stem Cell used stem cell technology to successfully regenerate patients' immune cells, creating large numbers that were long-lived and could recognize their specified targets: HIV-infected cells in one case and cancer cells in the other. The findings could help in the development of strategies to rejuvenate patients' exhausted immune responses.

The techniques the groups employed involved using known factors to revert mature immune T cells into induced pluripotent stem cells (iPSCs), which can differentiate into virtually any of the body's different cell types. The researchers then expanded these iPSCs and later coaxed them to redifferentiate back into T cells. Importantly, the newly made T cells were "rejuvenated" with increased growth potential and lifespan, while retaining their original ability to target cancer and HIV-infected cells. These findings suggest that manipulating T cells using iPSC techniques could be useful for future development of more effective immune therapies.

In one study, investigators used T cells from an HIV-infected patient. The redifferentiated cells they generated had an unlimited lifespan and contained long telomeres, or caps, on the ends of their chromosomes, which protect cells from aging. This is significant because normal aging of T cells limits their expansion, making them inefficient as therapies. "The system we established provides 'young and active' T cells for adoptive immunotherapy against viral infection or cancers," says senior author Dr. Hiromitsu Nakauchi, of the University of Tokyo.

The other research team focused on T cells from a patient with malignant melanoma. The redifferentiated cells they created recognized the protein MART-1, which is commonly expressed on melanoma tumors. "The next step we are going to do is examine whether these regenerated T cells can selectively kill tumor cells but not other healthy tissues. If such cells are developed, these cells might be directly applied to patients," says senior author Dr. Hiroshi Kawamoto, of the RIKEN Research Center for Allergy and Immunology. "This could be realized in the not-so-distant future."


'/>"/>

Contact: Mary Beth OLeary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Related medicine news :

1. A Revolutionary Dietary Paradigm: New Cookbook Features A SOS-free (Salt, Oil, Sugar ) Diet That Delivers the Optimal Food Plan for Renewing Health
2. Vygone Presents a Revolutionary Electro Waveform Device to Help Treat Molluscum Contagiosum Lesions
3. Naturel Collagen Canada Unveils C RUM, the Newest Addition to the Revolutionary Natural Collagen Skin Care Product Line
4. Brand id¦Strategic Partners Launches Revolutionary Personal Branding Success Program for Women
5. Mount Sinai Grad Student, 25, Named to Forbes ’30 Under 30’ In Science and Healthcare for ‘Revolutionary New Ideas’
6. New Techniques May Improve Infant Heart Surgery
7. New tools and techniques enhance laparoscopic gallbladder removal
8. Flu outbreaks predicted with weather forecast techniques
9. Improved techniques may help recovery and prevent incidents of missing drivers with dementia
10. Red wine, fruit compound could help block fat cell formation
11. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Revolutionary techniques could help harness patients' own immune cells to fight disease
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured or ... West Penn Burn Center, part of the Allegheny Health Network, has partnered with ... the “Space Heaters Need Space” campaign. , “Space Heaters Need Space” aims ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... ... February 12, 2016 , ... Vail knee specialist ... Leaders to Know in 2016 . The list consists of physicians establishing, leading and ... establish this list. , An Ambulatory Surgery Center, also known as an ASC, ...
(Date:2/12/2016)... PA (PRWEB) , ... February 12, 2016 , ... ... families of the Pittsburgh metro area, celebrates the beginning of the latest charity ... children develop social skills through art. Donations to this worthy cause are currently ...
(Date:2/12/2016)... MIAMI, FLA (PRWEB) , ... February 12, 2016 , ... ... free dental implants to their Miami dental office. Beginning in January, Miami Dental ... traditional titanium. Miami Dental Specialists are the first office to be chosen by the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)...  Clinical Affairs leaders at pharmaceutical organizations are looking to either ... world. While some companies have conducted a significant number of clinical ... countries such as India and ... India are now requiring local clinical trials ... --> China and India ...
(Date:2/12/2016)... 12, 2016 Hypermarcas S.A. ("Hypermarcas") today ... offer (the "Tender Offer") to purchase any and ... amount of its 6.500% Senior Notes due 2021 ... USP5246AAF05) (the "Notes"). In connection with the Tender ... consents (the "Consents") of the holders of the ...
(Date:2/12/2016)... , Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces its ... to Okaloosa County Emergency Medical ... III ambulances and one LT2 van. Quality Emergency Vehicles in ... is responsible for the sale.  This is the latest in ... , Executive Vice President at Demers. --> Benoit ...
Breaking Medicine Technology: