Navigation Links
Review of group-based cancer trials reveals flaws in studies' design and analysis
Date:3/25/2008

ng to do is simply raise the awareness of the research community that you need to attend to these special problems that we have with this kind of design.

The use of inappropriate analysis methods is not considered willful or in any way designed to skew results of a trial, Murray noted.

Ive seen creative reasons people give in their papers for using the methods they use, but Ive never seen anybody say it was done to get a more significant effect. But thats what can happen if you use the wrong methods and thats the danger, he said. What we want to know from a trial is what really happened. If an intervention doesnt work, we need to know that, too, so we can try something else.

The review also is not an indictment of the study design. Murray is a proponent of such trials and was the first U.S. expert to author a textbook on the subject (Design and Analysis of Group-Randomized Trials, Oxford University Press, 1998).

He also is a co-investigator on three group-randomized trials in progress at Ohio State. Two trials use specific clinics as the assigned groups. One is analyzing the effectiveness of having specially trained guides help cancer patients negotiate the health-care system. The second is investigating the effectiveness of aggressive physician promotion of colorectal cancer screening for patients with cancer risk factors. A third trial will use Appalachian counties as groups to compare the effectiveness of a media campaign to promote colorectal cancer screenings.

Were not trying to discourage people from using this design. It remains the best design available if you have an intervention that cant be studied at the individual level, Murray said.


'/>"/>

Contact: David Murray
dmurray@cph.osu.edu
614-293-2928
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Ingenuity Systems Delivers Key Milestones in FDA Collaboration to Facilitate Genomic Data Review
2. DuPont Chief Financial Officer Reviews Companys Accelerated Growth Plan
3. AllMed Survey of Hospital Quality Managers Shows Much Room for Improvement in Peer Review
4. Conseco Declines Partnerships Request for Board Seats; Review of Strategic Alternatives Underway
5. FDA Extends Review Timeline for Additional Indication for Antibiotic DORIBAX(TM)
6. Pregis Announces Investor Conference Call to Review 2007 Fourth Quarter and Full Year Financial Results
7. FDA Warning of Suicidal Risk Associated with Antidepressants in Juveniles and Young Adults Reviewed at Recent ISCTM Meeting
8. Sirion Therapeutics Receives NDA Acceptance and Priority Review From the FDA for Durezol(TM) in the Treatment of Postoperative Ocular Inflammation
9. PreMD Initiates FDA Review Process and Provides Corporate Update
10. iJET Unveils 2007 Year-in-Review Report on Avian Influenza and Pandemic Planning
11. Review of online breast cancer information encourages healthy skepticism for consumers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Angeles, CA (PRWEB) September 02, 2014 ... article on its website titled “Why You Should Wash ... than 80 percent of the global population breathes air ... and particles of pollution lodge in the skin’s pores ... body’s natural barrier to free radicals that may cause ...
(Date:9/2/2014)... groundwork for their own spread throughout the body by ... signals, according to a new report by Johns Hopkins ... Nature Communications , the researchers describe animal and ... molecules released by breast cancer cells. These molecules cause ... nodes to produce proteins called CCL5 and VEGF. CCL5 ...
(Date:9/2/2014)... By Kathleen Doheny ... -- The U.S. obesity epidemic is a driving force behind ... new study. Researchers looked at data from five national ... the increase in diabetes over time could be explained by ... in U.S. adults. The investigators found that the prevalence ...
(Date:9/2/2014)... News) -- A leading group of oncologists has released ... of advanced breast cancer. HER2-negative breast tumors ... the HER2 protein, the American Society of Clinical Oncology ... Almost 80 percent of women with advanced breast cancer ... this guideline, our aim is to improve both the ...
(Date:9/2/2014)... research on sleep apnea, tonsillectomies, hearing loss, head ... be presented in Orlando, FL, September 21-24, at ... the American Academy of OtolaryngologyHead and Neck Surgery ... nose, throat, head and neck physicians in the ... presented were released today, and are available online ...
Breaking Medicine News(10 mins):Health News:Simon Ourian, Kim Kardashian’s Doctor: Air Pollution May Be Aging Your Skin 2Health News:‘Prepped’ by tumor cells, lymphatic cells encourage breast cancer cells to spread 2Health News:Obesity Fueling Rise in Diabetes Rates, Study Finds 2Health News:Obesity Fueling Rise in Diabetes Rates, Study Finds 3Health News:New Guidelines for Treating Form of Advanced Breast Cancer 2
... women with a common thyroid problem may have a ... ,Studies in the past have shown that one of ... Although animal studies found mammary gland cells responded to ... in the relationship between thyroid hormone and breast cancer. ...
... allergen found in the air in many inner-city homes ... in children say researchers. ,According to researchers children ... allergy-causing substance found in mouse urine that is circulating ... developing allergic sensitivity to mice, just as it does ...
... live their lives by their sports drinks and energy drinks ... athletic achievements. //According to a study published in the January ... dental enamel is caused by bottled lemonade, sports drinks and ... enamel by these drinks are as much as 11 times ...
... there are actually scientific reasons why children may be ... strong // sweet tooth. Researchers found variation in a ... and adults. Age and culture also contribute to taste ... the study researchers compared taste sensitivity and food-related behaviors ...
... to evaluate the effect of diseases on contact with children ... were less likely to get the kind of affection other ... HIV-positive parents report avoided certain types of physical contact with ... to their children or pick up infections from the kids ...
... gum disease are more likely to suffer from atherosclerosis, or ... attack // or stroke shows latest research . ... mouths of 657 people who had no history of heart ... used to identify atherosclerosis, was also measured. People with a ...
Cached Medicine News:
(Date:9/2/2014)... , Sept. 2, 2014  XBiotech announced ... study being conducted in the US for its ... Human™ monoclonal antibody therapy, is being evaluated in ... complicated with cachexia. The primary endpoint of the ... treated patients to a control population provided only ...
(Date:9/2/2014)... , Sept. 2, 2014 Reportlinker.com announces ... in its catalogue: Acute Heart Failure ... http://www.reportlinker.com/p0689743/Acute-Heart-Failure-Global-Clinical-Trials-Review-H2-2014.html Acute Heart ... Summary GlobalData,s clinical trial report, "Acute ... provides data on the Acute Heart Failure clinical ...
(Date:9/2/2014)... 2014 According to a ... "Latin America Home Healthcare Market (By Device Types: ... Mobility Assist Devices and Medical Supplies; By Services: ... and Unskilled Home Healthcare Services) - Industry Analysis, ... 2020" the Latin American Home Healthcare market was ...
Breaking Medicine Technology:XBiotech Halts Study, Reports Positive Phase III Results with Antibody Therapy for Cancer 2Acute Heart Failure Global Clinical Trials Review, H2, 2014 2Acute Heart Failure Global Clinical Trials Review, H2, 2014 3Acute Heart Failure Global Clinical Trials Review, H2, 2014 4Acute Heart Failure Global Clinical Trials Review, H2, 2014 5Acute Heart Failure Global Clinical Trials Review, H2, 2014 6Acute Heart Failure Global Clinical Trials Review, H2, 2014 7Acute Heart Failure Global Clinical Trials Review, H2, 2014 8Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 2Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 3Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 4Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 5Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 6
... 27 Tengion, Inc. (Nasdaq: TNGN ), ... its first Analyst and Investor Meeting which was held ... and discussions of milestones and key data for the ... archive of the event and presentation materials will be ...
... DEL REY, Calif., Oct. 27 Prostate Oncology Specialists, ... sites in the nation to treat advanced prostate cancer ... therapeutic class known as autologous cellular immunotherapies.  PROVENGE was ... for the treatment of men with asymptomatic or minimally ...
Cached Medicine Technology:Tengion Reviews Pipeline Progress at First Analyst and Investor Meeting; Strategic & Clinical Updates Provided for Regenerative Medicine Programs 2Tengion Reviews Pipeline Progress at First Analyst and Investor Meeting; Strategic & Clinical Updates Provided for Regenerative Medicine Programs 3Tengion Reviews Pipeline Progress at First Analyst and Investor Meeting; Strategic & Clinical Updates Provided for Regenerative Medicine Programs 4Tengion Reviews Pipeline Progress at First Analyst and Investor Meeting; Strategic & Clinical Updates Provided for Regenerative Medicine Programs 5Prostate Oncology Specialists Among First in the Nation to Treat Advanced Prostate Cancer Patients With PROVENGE 2Prostate Oncology Specialists Among First in the Nation to Treat Advanced Prostate Cancer Patients With PROVENGE 3Prostate Oncology Specialists Among First in the Nation to Treat Advanced Prostate Cancer Patients With PROVENGE 4
...
For the qualitative detection of Wuchereria bancrofti antigen in whole blood, serum and plasma specimens...
For the qualitative detection of Hepatitis B surface Antigen (HBsAG) in human serum, plasma and whole blood specimens...
For the qualitative detection of Hepatitis B surface Antigen (HBsAG) in human serum, plasma and whole blood specimens...
Medicine Products: