Navigation Links
Review of group-based cancer trials reveals flaws in studies' design and analysis
Date:3/25/2008

a group level, manipulate the social or physical environment, or cannot be delivered to individuals in the same way a pill or surgical procedure can. For example, a group-randomized trial might study the use of mass media to promote cancer screenings and then assess how many screenings result among groups that receive different kinds of messages.

In analyzing the outcomes of such trials, researchers should take into account any similarities among group members or any common influences affecting the members of the same group, Murray said. But too often, this review found that the common ground among group members was not factored into the final statistical analysis.

What can result is called a Type 1 error, when a difference between outcomes in groups is found that doesnt really exist.

In science, generally, we allow for being wrong 5 percent of the time. If you use the wrong analysis methods with this kind of study, you might be wrong half the time. Were not going to advance science if were wrong half the time, said Murray, also a member of the Cancer Control Program in Ohio States Comprehensive Cancer Center.

The review identified 75 articles published in 41 journals that reported intervention results based on group-randomized trials related to cancer or cancer risk factors from 2002 to 2006. Thirty-four of the articles, or 45 percent, reported the use of appropriate methods used to analyze the results. Twenty-six articles, or 35 percent, reported only inappropriate methods were used in the statistical analysis. Eight percent of the articles used a combination of appropriate and inappropriate methods, and nine articles had insufficient information to even judge whether the analytic methods were appropriate or not.

Am I surprised by these findings" No, because we have done reviews in other areas and have seen similar patterns, Murray said. Its not worse in cancer than anywhere else, but its also not better. What were tryi
'/>"/>

Contact: David Murray
dmurray@cph.osu.edu
614-293-2928
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Ingenuity Systems Delivers Key Milestones in FDA Collaboration to Facilitate Genomic Data Review
2. DuPont Chief Financial Officer Reviews Companys Accelerated Growth Plan
3. AllMed Survey of Hospital Quality Managers Shows Much Room for Improvement in Peer Review
4. Conseco Declines Partnerships Request for Board Seats; Review of Strategic Alternatives Underway
5. FDA Extends Review Timeline for Additional Indication for Antibiotic DORIBAX(TM)
6. Pregis Announces Investor Conference Call to Review 2007 Fourth Quarter and Full Year Financial Results
7. FDA Warning of Suicidal Risk Associated with Antidepressants in Juveniles and Young Adults Reviewed at Recent ISCTM Meeting
8. Sirion Therapeutics Receives NDA Acceptance and Priority Review From the FDA for Durezol(TM) in the Treatment of Postoperative Ocular Inflammation
9. PreMD Initiates FDA Review Process and Provides Corporate Update
10. iJET Unveils 2007 Year-in-Review Report on Avian Influenza and Pandemic Planning
11. Review of online breast cancer information encourages healthy skepticism for consumers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... Early surgery may not be the best ... injuries, according to new research from Tripler Army Medical ... Society for Sports Medicine’s ( AOSSM ) Specialty Day, ... was not performed. , The final study group focused ... 17 receiving non-surgical therapy. Of the non-surgery group, 8 ...
(Date:3/28/2015)... 28, 2015 Healthpointe’s otolaryngologists, medical practitioners ... throat disorders, are now offering a wide variety ... which is characterized by the presence of phantom sounds ... people, tinnitus is a prevalent symptom that can arise ... is non-fatal, tinnitus can impede a person’s quality of ...
(Date:3/28/2015)... Servpro of Paso Robles , ... a report about the link between mold and asthma. ... according to recent medical research, may even cause asthma ... Environmental Protection Agency, people with sensitivity to mold or ... may trigger asthma attacks for asthma sufferers. The EPA ...
(Date:3/27/2015)... 2015 Florida Hospital is excited to continue ... exclusive health care provider for the 2015 and 2016 season. ... medical care and an athletic trainer for the team throughout ... its season against the Cleveland Gladiators at Amalie Arena; the ... extremely important to us as it gives us the opportunity, ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Healthpointe is ... G. Katz, M.D., is now treating knee and hip ... Anaheim , Long Beach, and La Mirada. Dr. ... acute knee and hip joint disorders as well as ... is passionate in returning his patients back to their ...
Breaking Medicine News(10 mins):Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2Health News:Water Damage Restoration Specialists Servpro of Paso Robles Release Report on Mold and Asthma 2Health News:Water Damage Restoration Specialists Servpro of Paso Robles Release Report on Mold and Asthma 3Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 2Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 3
... Website for People Seeking Quality Care , ... Atlanta, ... is pleased to announce Adventist Midwest Health as one of its ... highly targeted search engine optimization campaign, and over the course of ...
... county Star awarded Dr. Khanna the reader,s choice award for Westlake village ... for the most popular and caring local business represented in the newspaper. ... ... county Star awarded Dr. Khanna the reader,s choice award for ...
... Systems signs multi-year agreement with PureWellness to provide comprehensive employee wellness ... ... 10, 2009 -- PureWellness, Inc, a leading provider of online wellness ... based in Plano, TX, to provide a comprehensive online wellness program ...
... that Guy,s and St Thomas, NHS Foundation Trust ... digital dictation workflow system, further enhancing the Trust,s ... a number of specialties. The success of replacing ... system within Oncology and Renal has led the ...
... given financial incentives to improve the quality of ... of changes important to advancing quality, according to ... adopted by medical groups include speeding up adoption ... more closely tracking the improvement of physician performance ...
... With Patient Safety Awareness WeekSOUTH BEND, Ind., March ... Week, Press Ganey Associates, Inc. today released a ... assess the correlation between medical errors and the ... The report establishes a baseline for future efforts ...
Cached Medicine News:Health News:Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign 2Health News:Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign 3Health News:Ventura County Star Newspaper Honors Khanna Institute 2Health News:Global Leader in Information Technology Services and Business Solutions Signs Long-Term Agreement with PureWellness 2Health News:Global Leader in Information Technology Services and Business Solutions Signs Long-Term Agreement with PureWellness 3Health News:Guy's and St Thomas' NHS Foundation Trust extends patient care benefits of BigHand Digital Dictation 2Health News:Study finds pay for performance stimulates changes in medical practice 2Health News:Study finds pay for performance stimulates changes in medical practice 3Health News:Press Ganey Releases Innovative Report to Assess Culture of Safety in U.S. Hospitals 2Health News:Press Ganey Releases Innovative Report to Assess Culture of Safety in U.S. Hospitals 3
(Date:3/27/2015)... , March 27, 2015  Valeant Pharmaceuticals International, Inc. ... closing of its previously announced registered offering of common ... (the "Offering"). Pursuant to the Offering, the Company issued ... share, for aggregate gross proceeds of approximately $1.45 billion. ... U.S. Securities and Exchange Commission a final prospectus supplement ...
(Date:3/27/2015)... DALLAS , March 27, 2015   ... global leader in biosimilars and the world,s leading ... two studies that support an evaluation of biosimilarity ... U.S. Food and Drug Administration (FDA) conditionally approved ... Amgen,s EPOGEN™ (epoetin alfa). These study data were ...
(Date:3/27/2015)... YORK , March 27, 2015  Delcath ... pharmaceutical and medical device company focused on oncology ... and metastatic liver cancers, announces the reporting of ... Company,s Melphalan Hydrochloride for Injection with the Delcath ... a poster presentation at the Society of Surgical ...
Breaking Medicine Technology:Valeant Pharmaceuticals Closes Offering Of $1.45 Billion Of Common Shares 2Valeant Pharmaceuticals Closes Offering Of $1.45 Billion Of Common Shares 3Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 2Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 3Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 2Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 3Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 4Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 5
... , RICHMOND, Calif., Oct. 13 Sangamo BioSciences, Inc. ... its previously announced public offering of 3,000,000 shares of ... share. The net proceeds to Sangamo from the sale ... and commissions and other estimated offering expenses, were approximately ...
... Accuray Incorporated (Nasdaq: ARAY ), a global leader ... is scheduled to present at the Oppenheimer Healthcare Conference in ... a.m. ET (6:40 a.m. PT). , A live webcast of ... page of the Company,s Web site at http://www.accuray.com ...
Cached Medicine Technology:Sangamo Announces Closing of Common Stock Offering 2Sangamo Announces Closing of Common Stock Offering 3Accuray Incorporated to Present at 20th Annual Oppenheimer Healthcare Conference 2
BETADINE® Solution Swabsticks are indicated whenever a topical microbicide is applied most conveniently with a swabstick....
... contains 70% alcohol and 10% povidone ... base, forming a barrier on the ... environment for the povidone iodine, giving ... associated with catheter related infections for ...
... Aplicare's Saturated Swabsticks ... open, single-use foil-laminated pouches. ... is saturated with precisely ... solution. Each package is ...
... Swabsticks are packaged in easy open, single-use ... saturated with precisely the correct amount of ... the safest possible product for the patient. ... an excellent combination of ethyl alcohol and ...
Medicine Products: