Navigation Links
Review Finds No Evidence Alzheimer's, Parkinson's Are Infectious
Date:2/4/2013

By Alan Mozes
HealthDay Reporter

MONDAY, Feb. 4 (HealthDay News) -- A new analysis did not unearth any evidence to support concerns that neurological diseases such as Alzheimer's or Parkinson's might be infectious.

The finding stems from a review of Alzheimer's and Parkinson's disease risk among people who had received potentially contaminated human growth hormone from cadavers in the 1960s, '70s and '80s, as a treatment for stunted growth. Since then, a synthetic version of the growth hormone has been developed for these patients.

"Basically, the concern has been that the pathology of Alzheimer's or Parkinson's could be passed, or can move, from cell to cell," explained study author Dr. John Trojanowski, co-director of the Center for Neurodegenerative Disease Research and the Institute on Aging at the University of Pennsylvania School of Medicine, in Philadelphia.

"For example, there was recent evidence of cell-to-cell disease transfer among Parkinson's patients who underwent an experimental therapy in which nerve cells were transplanted into the brain," he said. "After 10 years, the grafted neurons developed Parkinson's pathology. In the same way, years back, cell-to-cell transmission was observed in so-called mad cow disease."

"But when we looked at a group of patients who had been injected with cadaver-derived pituitary extract decades ago, we found no individuals who had developed, 40 years later, either Alzheimer's or Parkinson's," Trojanowski added. "This suggests that there is no cell-to-cell transmission from human to human or from cell to cell."

Trojanowski and his colleagues reported the findings online Feb. 4 in the journal JAMA Neurology.

The U.S. National Institutes of Health notes that growth hormone deficiency results when the pituitary gland, which is situated at the base of the brain, fails to produce enough of the hormone, either as a result of congenital issues or following injury. The result can be an extremely slow rate of growth, resulting in shorter-than-average stature.

For affected patients, daily growth hormone injections are the standard of care. Prior to the development of synthetic growth hormone in 1985, this typically involved the use of hormones extracted from the pituitary glands of cadavers.

The authors said that between 1963 and 1985, roughly 7,700 American patients were treated with cadaver-derived growth hormone as part of a national program.

This practice was stopped, however, following the revelation that during the 1980s about 200 patients in the United States and abroad developed a rare and fatal brain disorder called Creutzfeldt-Jakob disease after having been injected with cadaver-derived growth hormone that was contaminated with abnormal proteins.

The new analysis revealed that, despite possible exposure to contaminated proteins, none of the patients who had undergone treatment with growth hormone from cadavers faced a higher risk for Alzheimer's, Parkinson's, frontotemporal lobar degeneration or amyotrophic lateral sclerosis -- also known as ALS or Lou Gehrig's disease.

"The bottom-line fear is that diseases such as Alzheimer's and Parkinson's might be transmissible and possibly infectious, which could be an issue beyond just human growth hormone patients," Trojanowski said. "Just think of all the organ transplants done in the U.S., and the risk of disease transmission if some of them use material that came from Alzheimer's or Parkinson's patients."

"This [new] study is not absolute proof that such transmissions can't happen," he acknowledged. "But, to my mind, it considerably allays such concerns."

Cheryl Grady, a senior scientist with the Rotman Research Institute in Toronto, agreed.

"I'm not at all surprised by these results," Grady said. "The only neuro-degenerative disease that I'm aware of as being transmittable is what people call mad cow disease, and one other disease called 'kuro,' which affected one cannibalistic tribe in New Guinea that used to eat their dead relatives."

"With so many transplants being done now, if something like this were a problem we would know about it," she added. "The issue with transplantation is not whether the new organ will make you sick, it's tissue rejection."

More information

For more on growth hormone deficiency, visit the U.S. National Institutes of Health.

SOURCES: John Trojanowski, M.D., Ph.D., professor, pathology and laboratory medicine, and co-director, Center for Neurodegenerative Disease Research and the Institute on Aging, department of pathology and laboratory medicine, University of Pennsylvania School of Medicine, Philadelphia; Cheryl Grady, Ph.D., senior scientist, Rotman Research Institute, Toronto; Feb. 4, 2013, JAMA Neurology, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. US Drug Watchdog Now Urges Diabetics Who Used the Diabetes Drug Actos and Then Developed Bladder Cancer to Call the Johnson Law Group for a Legal Review - Get Compensated
2. How To Get Rid Of Cold Sores
3. How “Cold Sore Free Forever” Treats Cold Sores Safely – HealthReviewCenter.com
4. Easy On Hold Reviews Latest Small Business Phone Systems for Music On Hold Ease and Functionality
5. Fibroid Treatment
6. How “Fibroids Miracle” Helps Women Remove Fibroid Naturally – HealthReviewCenter.com
7. Home Remedies For Yeast Infection
8. How “Natural Cure For Yeast Infection” Helps People Treat Candida Permanently – Health Review Center
9. Cellulite Factor: Review Examining Dr. Charles Livingston’s Program Released By CelluliteFactorReviews.org
10. Constipation Treatments Not Equally Effective: Review
11. Merrill DataSite Releases New Industry Insight on Jan 28th: 2012 M&A Review
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Review Finds No Evidence Alzheimer's, Parkinson's Are Infectious
(Date:2/27/2017)... ... February 27, 2017 , ... Anahata ... Spiritual Awakening, is happy to announce her “Spring Rejuvenation in Sedona” personally ... individual customized retreats offer the winter-weary soul an excellent opportunity to come out ...
(Date:2/27/2017)... ... ... Orange County dentist, Dr. A. Rassouli, comments on the new ... bacteria in plaque infect the gums and other tissues supporting the teeth. Treatment typically ... SRP, and can include surgical therapies if the condition has led to significant damage. ...
(Date:2/27/2017)... ... February 27, 2017 , ... Texas based ... In addition, Discount Power's RCE (Residential Customer Equivalent) count exceeds 150,000. ... company had 800 customers and 2,250 RCEs at the time of acquisition. In ...
(Date:2/27/2017)... ... ... New Jersey ranks among the top five states in the entire nation ... advanced services is growing. , Project WE vs C is a focused two-year ... non-profit partners in their fight against cancer and in support of their shared mission ...
(Date:2/26/2017)... ... February 26, 2017 , ... NuevaCare, a leading home care ... Millbrae, Belmont, and Palo Alto, is proud to announce an important upgrade to its ... look for home care close to home, and by having city-specific pages, NuevaCare is ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Research and Markets has announced the ... - Industry Forecast to 2025" report to their offering. ... The Global Wireless ... 23.8% over the next decade to reach approximately $330.5 billion by ... forecasts for all the given segments on global as well as ...
(Date:2/24/2017)... 2017 Research and Markets has announced the addition ... report to their offering. ... The latest research Hemophilia Drugs Price Analysis and Strategies - 2016, provides ... research answers the following questions: What are ... they positioned in the Global Hemophilia market? What are ...
(Date:2/24/2017)... 2017  In conjunction with DURECT Corporation,s (Nasdaq: ... release, you are invited to listen to a conference ... on Tuesday, March 14, 2017 at 4:30 pm Eastern ... audio webcast of the presentation will be available by ... "Investor Relations."  If you are unable to participate during ...
Breaking Medicine Technology: