Navigation Links
Reversing smoke-induced damage and disease in the lung
Date:10/13/2011

By studying mice exposed to tobacco smoke for a period of months, researchers have new insight into how emphysema and chronic obstructive pulmonary disease (COPD) develops. In the October 14th issue of Cell, a Cell Press publication, they also report a promising new way to reverse the lung damage underlying these conditions.

"It has not been very clear what causes the disease and there has been no therapy to stop or reverse lung destruction in emphysema," said Norbert Weissman of the University of Giessen Lung Center in Germany. "There have really been no new concepts about therapy in the last 20 years."

It's not for lack of interest, he said. In fact, COPD, including chronic bronchitis and emphysema, is expected to become the third-greatest cause of death worldwide by the year 2020.

In addition to airway inflammation and decreased of respiratory function, COPD is often accompanied by pulmonary hypertension, which is essentiallyhigh blood pressure in the lungs. Whether this condition was a cause or a consequence of COPD was not known.

Now, with powerful mouse models of COPD, Weissman and colleagues provide evidence that changes to the pulmonary blood vessels and the development of high blood pressure precede the development of emphysema. They further trace those effects to an inducible form of an enzyme known as nitric oxide synthase (iNOS), which catalyzes the formation of nitric oxide.

Nitric oxide (NO) and the nitric oxide system are important for opening up blood vessels and maintaining vascular tone, Weissman said. When nitric oxide levels grow too high, however, the molecule can undergo a chemical reaction forming aggressive peroxynitrite.

"Simply put, peroxynitrite can modify protein functions, leading to the destruction of lung tissue," Weissman said.

It appears this is exactly what happens in the development of emphysema. Mice lacking the iNOS enzyme were protected from both emphysema and pulmonary hypertension. Importantly, existing pharmacological agents can block iNOS activity, and mice treated with one of these drugs were protected from COPD-like changes to their lung vasculature. Treatment with the inhibitor also successfully reversed the course of the disease in the mice.

"For reversal of emphysema, you need active restructuring of the lung," Weissman said, noting that there is more work to do to explore the pathways involved.

The iNOS inhibitor used in these studies has already been used in clinical trials with apparently no major side effects, Weissman says. He and his team plan to pursue use of the drug as an inhaled therapy, with the hope that it may reach therapeutic concentrations only where it is needed


'/>"/>
Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Epigenetic pathway and new drug show promise in reversing a hard-to-treat childhood cancer
2. Liver-cell transplants show promise in reversing genetic disease affecting liver and lungs
3. A revolutionary new way of reversing certain cancers
4. Stem cells from cord blood could help repair damaged heart muscle
5. Rebooting the system: Immune cells repair damaged lung tissues after flu infection
6. Popular colorectal cancer drug may cause permanent nerve damage
7. Researchers identify enzyme that regulates degradation of damaged proteins
8. Kidney damage and high blood pressure
9. Problem Drinking Linked to Brain Damage
10. Cam-type deformities linked to MRI detected hip damage in asymptomatic young men
11. Stomach bacterium damages human DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , ... May 24, 2016 , ... ... safety signs and safety labels , has been featured in ... Laser Labels.” , The eiXtra e-newsletter provides electroindustry professionals with manufacturer, regulatory, and ...
(Date:5/24/2016)... ... , ... After graduating from Cornell, author Joshua Alexander was diagnosed ... living on Social Security disability and staying in a group home. In “ Healing ... by Balboa Press), Alexander shares how he was finally able to heal with the ...
(Date:5/24/2016)... Lafayette, Colorado (PRWEB) , ... May 24, 2016 ... ... landscape architecture firm, announces the grand opening of ‘El Centro del Quinto Sol ... citizens of the Pueblo ‘east side’ community to offer something special for this ...
(Date:5/24/2016)... ... May 24, 2016 , ... NutraPre today announced the nationwide ... women to prevent morning sickness and promote overall heath. Engineered with advanced nanotechnology, ... taste of water. , “Imagine a pregnancy without morning sickness,” NutraPre CEO Eddie ...
(Date:5/23/2016)... ... May 23, 2016 , ... According to an article published May 12th on ... in oral health and hygiene. The article points out that, as long as patients are ... will become worn and frayed. Of course, these worn-out bristles won’t clean teeth and gum ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... --Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today the start ... hands-on learning experience is a 12-week summer program, May ... and Internship programs bring participants to ... are provided optional housing free of charge through Diplomat ... Riverfront Residence Hall to foster communication and collaboration among ...
(Date:5/23/2016)... JERUSALEM , May 23, 2016 ... DNA for detection of multiple diseases; ,Technology to be ... Yissum Research Development Company of the ... entered into a research agreement with Aurum Ventures MKI, the ... the development of a new diagnostic approach for early ...
(Date:5/22/2016)... DS Biopharma (DS) today ... compound DS102 in chronic obstructive pulmonary disease (COPD) ... patients. Recent DS preclinical data suggests ... and has bronchodilatory, anti-inflammatory and anti-fibrotic properties in ... will publish further detail on these findings later ...
Breaking Medicine Technology: