Navigation Links
Revealing the workings of 'Mother Nature's blowtorch'
Date:9/14/2007

ANN ARBOR, Mich.---Using atom-level imaging techniques, University of Michigan researchers have revealed important structural details of an enzyme system known as "Mother Nature's blowtorch" for its role in helping the body efficiently break down many drugs and toxins.

The research has been detailed in a series of papers, the most recent published online this month in the journal BBA Biomembranes.

The system involves two proteins that work cooperatively. The first, cytochrome P450, does the actual work, but only when it gets a boost from the second protein, cytochrome b5. To complicate matters, the two proteins can interact only when both are bound to a cell membrane. That makes it difficult to use traditional techniques to discern the structural details that are crucial to the interaction, said Ayyalusamy Ramamoorthy, who leads the research group.

For instance, X-ray crystallography, often used to determine protein structures, requires separating the molecules from their membrane environment. Because part of cytochrome b5 sticks to the membrane, such separations involve breaking the molecule at the sticking point, which happens to be the part that controls its interaction with cytochrome P450. So while crystallography can offer some information on structure, it can't provide insights into exactly what goes on between P450 and b5 during their cozy, membrane-bound encounters, Ramamoorthy said.

However, the technique his lab uses---solid state NMR spectroscopy---can produce detailed images of proteins in the membrane environment, not only revealing molecular structure but also showing how a particular protein nestles into the membrane. Cytochrome b5 presented a challenge even to that versatile method, though, because the molecule has three parts that all behave differently: the rigid, sticky portion that buries into the cell membrane, a highly mobile, water-soluble portion, and a less mobile "linker" that connects the other t
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Revealing Study Results May Do More Harm Than Good
2. Gay and HIV + men have no qualms revealing HIV status
3. Court Fines Newspaper for Revealing AIDS Orphans Identity
4. Molecular Basis of Obesity-Revealing the Unknown Facts
5. Revealing the Secrets of Gut Ecosystem
6. Scientists Uncover Complex Workings of Sperm
7. Acupuncture May Help Chemotherapy Side Effects
8. Grandmother’s diet in pregnancy can affect grandchildren’s blood sugr
9. Allergies are related to mothers menses
10. Mothers with periodontitis may deliver premature babies
11. Chemotherapy Pill Has Fewer Side Effects Than IV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2015)... IN (PRWEB) March 29, 2015 The culmination ... world is coming when the Final Four invades ... basketball tournament has been one filled with excitement, buzzer-beaters, and ... have been busted, superstars have been made, and future professional ... just be down to the four teams that advanced through ...
(Date:3/29/2015)... 2015 The Claudia Cohen Research ... announce today that Dr. Beth Y. Karlan has ... Cohen Research Foundation Prize for Outstanding Gynecologic Researcher. The ... Gynecologic Oncology 46th Annual Meeting on Women's Cancer in ... Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer ...
(Date:3/29/2015)... New York, NY (PRWEB) March 29, 2015 ... operators that conduct clinical trials and research, manage ... products to help their clients reach regulation standards. ... the pharmaceutical and medical device manufacturing sectors. Industry ... services, from early- to late-stage clinical research for ...
(Date:3/29/2015)... York, NY (PRWEB) March 29, 2015 ... treatment lawsuits ( http://www.testosteronelawsuithub.com/ ) pending in the ... scheduled the litigation’s next Case Management Conference for ... that the meeting will address the progress of ... who allegedly experienced heart attacks, strokes and other ...
(Date:3/29/2015)... March 29, 2015 At this ... platform provides basic health information around medical conditions ... discuss these challenges as well as helping them ... addresses six medical conditions using evidenced based information ... engage in conversations around them., ...
Breaking Medicine News(10 mins):Health News:Cheap 2015 Final Four Tickets: Ticket Down Slashes Kentucky Wildcats and Wisconsin Badgers Final Four Tickets at Lucas Oil Stadium and Issues Valuable Promo Code 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 3Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 4Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Federal Court Overseeing Testosterone Treatment Lawsuits Schedules April Case Management Conference 2Health News:Federal Court Overseeing Testosterone Treatment Lawsuits Schedules April Case Management Conference 3Health News:Krame Health Solutions Announces Release of AfroHealthLink, an Interactive Health Resource Center Tailored to Individuals of African & Caribbean Descent Around the World 2Health News:Krame Health Solutions Announces Release of AfroHealthLink, an Interactive Health Resource Center Tailored to Individuals of African & Caribbean Descent Around the World 3
... Anderson Cancer Center suggest that the use of an anti ... tumor growth in the// human pancreas and also resulted in ... National Cancer Institute issued on Dec.20 reported that a combination ... effective than just the administration of chemotherapy agent gemcitabine. ...
... stress-relief by just holding her husband’s hand, says a study. ... that the institution of marriage// is losing ground. ... the University of Virginia, finds that women in a threatening ... hand and this has been observed in brain scans. ...
... cards from active members of the,British Lung Foundation, warning ... to Chronic Obstructive Pulmonary Disease (COPD) patients in Scotland. ... be set, to ensure patients received the best quality ... Disease is a term that refers to a number ...
... Testosterones can slow down the progression of Alzheimer's disease ... the primary male sex hormone, is one// in a ... , The findings, published in the December ... insight into the relationship between testosterone loss and AD, ...
... and keeping active to stay fit, old people especially those ... agile, if they just indulge// in brain exercises, to enhance ... in age, researchers said. ,Previous insights have indicated ... mind games. The study led by Sherry Willis, a human-development ...
... possible by Colonoscopy. More patients are willing to undergo this ... bud at the very onset. ,Cary Gross, ... University, found that there is a significant rise in colonoscopy ... in people .This has helped early treatment possible. ...
Cached Medicine News:Health News:Anti Allergy Drugs Reduce Tumor Growth 2Health News:Anti Allergy Drugs Reduce Tumor Growth 3Health News:Increase Testosterone Levels To Slow Down Alzheimer’ 2Health News:Colonoscopy Aids Early Detection of Colon Cancer 2
(Date:3/29/2015)... , March 29, 2015  Three-month paliperidone ... to relapse compared to placebo in patients with ... study published this week in the ... . Results of the study ... Drug Application (NDA) filing for three-month paliperidone palmitate ...
(Date:3/27/2015)... , March 27, 2015 BioCorRx, Inc. ( ... Santa Ana, California is a healthcare solutions organization, ... is estimated at $22 billion in the U.S. alone. The ... of FDA-approved Naltrexone in a specially compounded form for outpatient ... Australia and New Zealand ) ...
(Date:3/27/2015)... N.C. , March 27, 2015 Across ... essential to meeting challenges in clinical development, market education, ... tighter regulations, the Medical Affairs function is expected to ... mature markets. According to research by ... participants have a group dedicated to Medical Affairs. Among ...
Breaking Medicine Technology:New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 2New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 3New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 4New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 5New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 6New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 7New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 8New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 9New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 10New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 11New Study Published in JAMA Psychiatry Found Three-Month Paliperidone Palmitate Significantly Delayed Time to Relapse in Patients with Schizophrenia 12Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2
... N.J., Jan. 3, 2012  Ikaria, Inc., a critical care ... critically ill patients in the hospital and ICU settings, ... program, the PRESERVATION I clinical trial, for its Bioabsorbable ... commenced in Australia, and will be followed in Europe.  ...
... 3, 2012 Reportlinker.com announces that a ... its catalogue: Transdermal Drug ... http://www.reportlinker.com/p0203552/Transdermal-Drug-Delivery---Technologies-Markets-and-Companies.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ... -Up-to-date one-stop information on transdermal drug ...
Cached Medicine Technology:Ikaria® Commences Global Registration Trial for Bioabsorbable Cardiac Matrix 2Ikaria® Commences Global Registration Trial for Bioabsorbable Cardiac Matrix 3Transdermal Drug Delivery - Technologies, Markets, and Companies 2Transdermal Drug Delivery - Technologies, Markets, and Companies 3Transdermal Drug Delivery - Technologies, Markets, and Companies 4Transdermal Drug Delivery - Technologies, Markets, and Companies 5Transdermal Drug Delivery - Technologies, Markets, and Companies 6Transdermal Drug Delivery - Technologies, Markets, and Companies 7Transdermal Drug Delivery - Technologies, Markets, and Companies 8Transdermal Drug Delivery - Technologies, Markets, and Companies 9Transdermal Drug Delivery - Technologies, Markets, and Companies 10Transdermal Drug Delivery - Technologies, Markets, and Companies 11
MRI curette, 8.5" overall length....
15" overall length, 5" handle....
10" overall length, 5" handle....
...
Medicine Products: