Navigation Links
Revealed:Protein's role in preventing heart muscle growth leading to heart failure
Date:5/12/2014

Cardiovascular disease remains the number one cause of death in the Western world, with heart failure representing the fastest-growing subclass over the past decade. The stage that precedes heart failure in a significant number of cardiovascular diseases is pathological hypertrophy the growth of the heart muscle in an attempt to increase its output.

Not all hypertrophy is pathological; for example, during pregnancy or high physical exertion, the muscle of the heart grows but myocardial function remains normal. But when hypertrophy is excessive, prolonged and unbalanced, it becomes pathological, leading to heart failure and arrhythmias.

Now for the first time, researchers at the Hebrew University of Jerusalem's Faculty of Medicine have revealed how a protein called Erbin acts as a brake against this excessive and pathological growth of heart muscle. They also demonstrated that damage to this protein leads to excess growth of heart muscle, a decrease in function, and severe pathological growth of heart muscle.

The research was conducted by Ms. Inbal Rachmin as part of her doctoral thesis, under the supervision of Prof. Ehud Razin and Dr. Sagi Tshori at the Institute for Medical Research IsraelCanada in the Faculty of Medicine at the Hebrew University of Jerusalem. The study, "Erbin is a negative modulator of cardiac hypertrophy," was published in the Proceedings of the National Academy of Sciences (PNAS).

Ms. Rachmin detected a significant decrease in the expression of the protein Erbin in the heart tissue of patients suffering from heart failure. Moreover, the induction of hypertrophy in mice lacking Erbin led to the early death all of these mice, compared to only about 30 percent mortality observed in the control group. Histological examination showed that heart failure was the main reason for this.

This important research also has further implications in the area of breast cancer treatment. Erbin
'/>"/>

Contact: Dov Smith
dovs@savion.huji.ac.il
972-258-82844
The Hebrew University of Jerusalem
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New clues found to preventing lung transplant rejection
2. National plan for preventing healthcare-associated infections shows progress
3. New study shows promise for preventing therapy resistance in tumor cells
4. LA BioMed study finds daily antibiotics most effective in preventing recurrent urinary tract infection
5. Preventing Outdoor Decks From Failing
6. UV Technologies, LLC, Makers of UV-Aid® Release Results of Study Showing Photo-Oxidation Technology Highly Effective in Preventing Colds, Flu, and Ear Infections
7. Life Insurance for Seniors and the Importance of Preventing Chronic Diseases
8. Tips for Preventing Kitchen Hassles Released in New Article from Apollo Plumbing
9. Top hospitals reduce readmissions by preventing complications across all diagnoses
10. Edoxaban effective in preventing stroke, reducing bleeding and cardiovascular death in patients with atrial fibrillation
11. Seven Helpful Tips For Preventing Back Pain In Those With Sedentary Jobs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... November 22, 2014 Setria® Glutathione ... (TGA) approved it for use “as a therapeutically ... listed within the Therapeutic Goods (Listing) Notice 2014 ... Kyowa Hakko’s Setria® Glutathione will be exclusivity distributed ... that sources and imports fine chemicals to Australian ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Nocturia ... as the complaint that the individual has to ... voiding. The report “Nocturia – Pipeline Review, H2 ... for Nocturia, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ...
(Date:11/22/2014)... 22, 2014 (HealthDay News) -- The wide variety and ... a threat for people with food allergies, an expert ... so many types of food allergies that it can ... holidays," Dr. Guha Krishnaswamy, director of allergy and clinical ... a hospital news release. "If you know you ...
(Date:11/22/2014)... 2014 Hastings and Hastings, a discount ... announces providing clients with the option of leaving an ... a flexible, intuitive and easy to navigate website that ... to Google + allows clients to research the Hastings ... more informed decision when retaining an attorney. Those who ...
(Date:11/22/2014)... Boulder, CO (PRWEB) November 22, 2014 ... on growth equity investments in the consumer brand ... LLC. The investment will be used to help ... new product pipeline rollout, particularly its proprietary apparel ... Suslow will join BackJoy’s Board of Directors. , ...
Breaking Medicine News(10 mins):Health News:Setria® Glutathione Now Available in Australia 2Health News:Setria® Glutathione Now Available in Australia 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4Health News:'Tis the Season of Challenges for Those With Food Allergies 2Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 2Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 3Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3
... the sleep disturbances, study finds , WEDNESDAY, Dec. 2 (HealthDay ... increase the risk of sleep apnea, say U.S. researchers. , ... damages the brain and can cause immediate and dangerous problems ... the Johns Hopkins School of Medicine in Baltimore, said in ...
... say , WEDNESDAY, Dec. 2 (HealthDay News) -- New research ... in the lives of people with Fabry disease, a rare ... The progressive disease, linked to the lack of an enzyme ... fatal because it boosts the risk for a stroke, heart ...
... 2 Huntington Memorial Hospital,s stroke program has received ... designating the hospital a primary stroke center. This ... center" hospitals throughout Los Angeles County. , ... more important, a wonderful benefit for Pasadena and its ...
... SAN FRANCISCO, Dec. 2 In the wake of the ... plastics chemical linked to birth defects and breast cancer, Congress ... House and Senate are considering bills to ban bisphenol A, ... Sen. Dianne Feinstein of California and Rep. Edward Markey of ...
... , ... , WASHINGTON, Dec. 2 The membership of the National Quality ... and reappointed four current Board members. The new Board members represent ... suppliers, and public and community healthcare. , The newly elected ...
... , NEW YORK, Dec. 2 Care ... Advanced Illness Coordinated Care (AICC) , has been shown to reduce ... the quality of life for seniors and their family caregivers without ... published in American Journal of Managed Care (November 2009). ...
Cached Medicine News:Health News:Ecstasy Users at Higher Risk of Sleep Apnea 2Health News:Huntington Hospital Earns Designation as Primary Stroke Center 2Health News:Pre-Polluted Babies: Congress Must Act to Protect Infants, Moms from Toxic Plastics Chemical BPA 2Health News:National Quality Forum Members Elect Nine Directors to Board 2Health News:National Quality Forum Members Elect Nine Directors to Board 3Health News:Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care 2Health News:Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care 3Health News:Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care 4
(Date:11/21/2014)... , Nov. 21, 2014  Alere Inc. (NYSE: ... diagnostic tests, has appointed Juliet Cunningham as ... Cunningham will be responsible for driving communications with the ... on a series of changes to increase shareholder value, ... to investors," said Namal Nawana, Chief Executive Officer. "We ...
(Date:11/21/2014)... 2014 In September 2014, the staff at ... a new product development plan that started with the ... lab coat , aptly named "Vera G.," after ... the world. The new women,s designer lab coat is ... sleek envelope collar, vertical princess and high waist seaming, ...
(Date:11/21/2014)... , Nov. 21, 2014  Abaxis, Inc. (NasdaqGS: ... instruments and consumables for the medical, research, and veterinary ... veterinary and research markets in the United ... stock purchase agreement to acquire 100% of QCR & ... based distribution organization. The transaction closed on November ...
Breaking Medicine Technology:Alere Appoints Juliet Cunningham to Lead Investor Relations 2Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4
Shielding's Wrap-Around Apron is designed for front and back protection. This apron features extra wide shoulders distributing weight over a greater area to reduce fatigue....
... Apron has standard front protection. ... from the shoulders to the ... a 6" wide elastic belt. ... apron snug. Belts may be ...
Shielding's Fast Wrap Apron offers both comfort and ease of wearing. Adjustable back shoulder strap keeps apron snug. No ties or buckles....
Shielding's Standard Coat Apron with open back allows for freedom of movement, maximum flexibility and increased comfort....
Medicine Products: