Navigation Links
Returning genetic incidental findings without patient consent violates basic rights
Date:5/17/2013

MINNEAPOLIS/ST. PAUL (05/15/2012)Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of genome sequencing, an enormous debate has erupted over whether patients' rights will continue in an era of medical genomics.

Recent recommendations from the American College of Medical Genetics and Genomics (ACMG) suggest no. On March 22, the ACMG released recommendations stating that when clinical sequencing is undertaken for any medical reason, laboratories must examine 57 other specific genes to look for incidental findings. These findings must then be reported to the clinician and the patient. In an April 25 "clarification," ACMG said that failure to report these findings would be considered "unethical." The patient has no opportunity to opt-out of the testing of the 57 genes, except to decline all sequencing. The recommendations also apply to children.

In a paper to be published in 'Science 'May 16 online ahead of print, authors Susan M. Wolf, J.D. (University of Minnesota), George J. Annas, J.D., M.P.H. (Boston University), and Sherman Elias, M.D. (Northwestern University) push back against these recommendations, and offer compelling reasons why patient autonomy must remain firmly in place as science advances. Their article on Patient Autonomy and Incidental Findings in Clinical Genomics urges ACMG to reconsider their recommendations. This article is published with a reply by Amy McGuire, J.D., Ph.D. (Baylor College of Medicine) and colleagues.

Wolf, Annas, and Elias argue that, "The ACMG's 'minimum list [of 57 genes]' includes mutations in genes that patients have long been able to refuse testing for, including cancer risk mutations (such as BRCA1) and cardiovascular risk mutations." They point out that "There are many circumstances in which a patient may decline su
'/>"/>

Contact: Martha Coventry
coven002@umn.edu
612-625-2948
University of Minnesota
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Coffee may help prevent breast cancer returning, study finds
2. AuDNet Pushes for Professional Hearing Tests for All Troops Returning from the Middle East.
3. XRMD: Beyond AREDS2: Vision Improvement using Hormones, Genetics, Methylation, Nutrition and Anti-Oxidative Therapy
4. The developmental genetics of space and time
5. GB HealthWatch Links Genetic Makeup, Omega-6 and Nuts
6. Scientists Discover More Genetic Clues to Testicular Cancer
7. UCLA stem cell researchers move toward treatment for rare genetic nerve disease
8. Champion of Genetics funding to Ottawa researcher
9. Ottawa researcher named 2013 Champion of Genetics
10. Genetic variations associated with susceptibility to bacteria linked to stomach disorders
11. Research Suggests that Lack of Exercise Drive is Genetic, Making Energy Enhancing Supplements Like Prescopodene Beneficial For Sticking to Your Exercise Routine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... September 03, 2014 UWDress.com, an experienced ... has added a lot of fashionable bridesmaid dresses ... the company has launched a special offer to celebrate ... price, from 20 to 60 percent off. , ... to announce our new fashionable bridesmaid dresses for consumers ...
(Date:9/2/2014)... September 03, 2014 Recently, iFitDress.com, a ... occasion gowns, has released its range of 2014 ... now offered at low prices. A large proportion of ... beautiful products from iFitDress.com are carefully made by the ... also offers bachelorette party gowns, ivory satin wedding gowns, ...
(Date:9/2/2014)... 2014 TCG, a leading government technology strategy ... one of the fastest-growing companies in America for the seventh ... was previously recognized in 2013, 2012, 2011, 2010, 2009, 2008, ... grown 86% from 2010 to 2013, ranking the company at ... in America - up 635 spots from 2013! More information ...
(Date:9/2/2014)... On August 30, 2014, Harper’s Bazaar ... You Should Wash Your Face .” According to ... population breathes air considered polluted by the World Health ... the skin’s pores destroying its natural oils. These oils ... that may cause cell damage, redness, aging skin ...
(Date:9/2/2014)... for their own spread throughout the body by coaxing ... according to a new report by Johns Hopkins scientists. ... Nature Communications , the researchers describe animal and cell-culture ... released by breast cancer cells. These molecules cause lymphatic ... to produce proteins called CCL5 and VEGF. CCL5 attracts ...
Breaking Medicine News(10 mins):Health News:Elegant Bridesmaid Dresses For 2014, Latest Designs From UWDress.com 2Health News:Discounted Seashell Wedding Dresses Currently Provided By iFitDress.com 2Health News:TCG One of the Fastest-Growing Companies in America – for the Eighth Time! 2Health News:Simon Ourian, Kim Kardashian’s Doctor: Air Pollution May Be Aging Your Skin 2Health News:‘Prepped’ by tumor cells, lymphatic cells encourage breast cancer cells to spread 2
... rely on outdated data when making ,off-label, decisions, study says ... always have complete or clear information when they prescribe cancer ... for, a new study finds. , According to ... Annals of Internal Medicine , the online and hard-copy ...
... SAN DIEGO, Feb. 17 Tracon Pharmaceuticals, a biotechnology ... diseases, announced today that its three clinical stage cancer ... the 100th Annual Meeting of the American Association for ... "Each program targets a unique pathway with the potential ...
... Upsher-Smith Laboratories,Inc. announced today the publication of results ... estradiol gel 0.1% is an,effective treatment for relief of ... objective of the study was to evaluate the efficacy ... 0.5 mg, and, 0.25 mg/day,including the lowest approved dose ...
... Feb. 17 HotHead Technologies, Inc. today,announced that the ... results by Kennesaw State University researchers as ... "It,s exciting news that research from a ... able to verify much earlier than we anticipated, in,the ...
... 17 Cancer may well surpass cardiovascular,diseases as the ... To prevent this from,happening, cancer therapeutics have to shift ... total cure, despite the complex, multifactorial nature,of cancer indications. ... , "As cancer spreads rapidly ...
... KEEP YOUR PLEDGES BUT DON,T DENY YOUR TASTE BUDS ... ... OAKS, Calif., Feb. 17 /PRNewswire/ -- Creative cooking ... when millions around the world fast and give up their ... lemons are high during the season providing flavor and favor ...
Cached Medicine News:Health News:Doctors' Guide to Cancer Drugs May Need Revising 2Health News:Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 2Health News:Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 3Health News:Newly Published Menopause Study: 'Bioidentical' and FDA-Approved Divigel(R) (estradiol gel) 0.1 Percent Safe and Effective Treatment for Moderate to Severe Hot Flashes Associated With Menopause 2Health News:Newly Published Menopause Study: 'Bioidentical' and FDA-Approved Divigel(R) (estradiol gel) 0.1 Percent Safe and Effective Treatment for Moderate to Severe Hot Flashes Associated With Menopause 3Health News:Newly Published Menopause Study: 'Bioidentical' and FDA-Approved Divigel(R) (estradiol gel) 0.1 Percent Safe and Effective Treatment for Moderate to Severe Hot Flashes Associated With Menopause 4Health News:HotHead Technologies' Heat Sensor Shows Exciting Potential by Kennesaw State University Researchers 2Health News:Frost & Sullivan Says, Innovative Therapies Needed to Deal With the Rapid Spread of Cancer in Europe 2Health News:Frost & Sullivan Says, Innovative Therapies Needed to Deal With the Rapid Spread of Cancer in Europe 3Health News:Frost & Sullivan Says, Innovative Therapies Needed to Deal With the Rapid Spread of Cancer in Europe 4Health News:Sunkist(R) Lemons Freshen Up Lenten Foods 2Health News:Sunkist(R) Lemons Freshen Up Lenten Foods 3
(Date:9/2/2014)...  On July 31, the Food and Drug Administration ... moving forward to regulate laboratory-developed tests (LDTs). The clock ... the U.S. will need to comply with a host ... may subscribe to the strategy to simply sit back ... place, it,s widely acknowledged that failure to answer key ...
(Date:9/2/2014)... Sept. 2, 2014 Reportlinker.com announces that a ... Asia - Pacific Minimally Invasive Surgery ... The growth rate of the ... will remain at double-digit levels throughout the forecast period. ... future of this field. The Asia-Pacific ...
(Date:9/2/2014)... , Sept. 2, 2014 Reportlinker.com announces ... in its catalogue: BRIC Bariatric ... http://www.reportlinker.com/p02343483/BRIC-Bariatric-Surgery-Devices-Market-Outlook-to-2020.html BRIC Bariatric ... Summary GlobalData,s new report, "BRIC ... key market data on the BRIC Bariatric Surgery ...
Breaking Medicine Technology:FDA Tells Congress It Intends to Regulate LDTs! Web Conference to Provide Straight Talk on Essential Steps Clinical Laboratories and Pathology Groups Will Need to Take to Comply 2FDA Tells Congress It Intends to Regulate LDTs! Web Conference to Provide Straight Talk on Essential Steps Clinical Laboratories and Pathology Groups Will Need to Take to Comply 3Asia - Pacific Minimally Invasive Surgery Spinal Device Market 2Asia - Pacific Minimally Invasive Surgery Spinal Device Market 3Asia - Pacific Minimally Invasive Surgery Spinal Device Market 4Asia - Pacific Minimally Invasive Surgery Spinal Device Market 5Asia - Pacific Minimally Invasive Surgery Spinal Device Market 6Asia - Pacific Minimally Invasive Surgery Spinal Device Market 7Asia - Pacific Minimally Invasive Surgery Spinal Device Market 8Asia - Pacific Minimally Invasive Surgery Spinal Device Market 9Asia - Pacific Minimally Invasive Surgery Spinal Device Market 10BRIC Bariatric Surgery Devices Market Outlook to 2020 2BRIC Bariatric Surgery Devices Market Outlook to 2020 3BRIC Bariatric Surgery Devices Market Outlook to 2020 4BRIC Bariatric Surgery Devices Market Outlook to 2020 5BRIC Bariatric Surgery Devices Market Outlook to 2020 6BRIC Bariatric Surgery Devices Market Outlook to 2020 7BRIC Bariatric Surgery Devices Market Outlook to 2020 8BRIC Bariatric Surgery Devices Market Outlook to 2020 9BRIC Bariatric Surgery Devices Market Outlook to 2020 10
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) announced ... of Directors. Mr. Ringo currently serves as Executive Partner at ... and as a Senior Advisor to Barclays Capital. ... expertise will be invaluable as we look to expand our ...
... CareFusion Corp. (NYSE: CFN ), a leading, ... and six months ended Dec. 31, 2010. "Our ... our Infusion, Dispensing and Infection Prevention businesses, and a benefit ... chairman and CEO, who had announced in November 2010 his ...
Cached Medicine Technology:Onyx Pharmaceuticals Appoints Bill Ringo to Board of Directors 2Onyx Pharmaceuticals Appoints Bill Ringo to Board of Directors 3CareFusion Reports Second Quarter Fiscal 2011 Results 2CareFusion Reports Second Quarter Fiscal 2011 Results 3CareFusion Reports Second Quarter Fiscal 2011 Results 4CareFusion Reports Second Quarter Fiscal 2011 Results 5CareFusion Reports Second Quarter Fiscal 2011 Results 6CareFusion Reports Second Quarter Fiscal 2011 Results 7CareFusion Reports Second Quarter Fiscal 2011 Results 8CareFusion Reports Second Quarter Fiscal 2011 Results 9CareFusion Reports Second Quarter Fiscal 2011 Results 10CareFusion Reports Second Quarter Fiscal 2011 Results 11CareFusion Reports Second Quarter Fiscal 2011 Results 12CareFusion Reports Second Quarter Fiscal 2011 Results 13CareFusion Reports Second Quarter Fiscal 2011 Results 14CareFusion Reports Second Quarter Fiscal 2011 Results 15
Versatility of the DFS Standard Fixator provides unsurpassed below-the-ring correction of angular, rotational and translational deformities. Length discrepancy can be precisely corrected in 1/4mm inc...
The PreFix™ temporary fixator prepares you for any situation that requires rapid stabilization of complex fractures....
Angulation, translation and rotation. A whole different point of view. The Sheffield Ring Fixation System is a design achievement that advances the possibilities of fracture management....
For radial/ulnar translation, angulation, dorsal/volar translation, and incremental longitudinal distraction, this advanced system is appropriate when incremental adjustment provides an adjunctive me...
Medicine Products: