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Resveratrol: Thousands of Bottles of Wine, High-Dose Pills Not Required; Mega-doses May Induce Side Effects
Date:6/3/2008

ay of beneficial molecules which magnify its effect, says Sardi. A resveratrol- based nutraceutical matrix that closely mimics the effect of red wine without the alcohol, calories and preservatives is what Longevinex(R) is.

Factors that determine safe dosage

Age, gender, diet and iron stores determine the resveratrol dosage required for optimal health. Red wine resveratrol pills are not appropriate for growing children or menstruating females, who have higher demand for minerals. However, Sardi explains that some consumers may benefit from a higher loading dose and a lower long-term maintenance dose.

Consumers need to recognize the health benefits of resveratrol and related molecules emanate from their mineral chelating (removal) properties, which then influence the genome, says Sardi. [BMC Genomics 8: 379, 2007; Biochmica Biophysica Acta 1619: 113-24, 2003] Middle-aged males and postmenopausal females have accumulated stores of excess iron and calcium which can be removed by natural mineral chelators, like those provided in Longevinex(R).

"A middle-aged male will typically have a higher load of stored iron and calcium and may benefit from a higher loading dose of mineral chelators, to speed along their removal, followed by a lower dose for long-term maintenance," says Sardi. He also suggests a relatively low iron and calcium diet to accompany a dietary supplement regimen intended to produce longevity. Humans live longer in countries where calcium and iron intake are low, such as Japan, he says.

When does aging begin?

Sardi explains a theory of why molecules like resveratrol slow the aging process. He says human aging begins only after full childhood growth is achieved. Until then, there are no observable aging changes in living cells. But once childhood growth ceases, iron, copper and calcium, which were directed towards building new bone and red blood cells, now begin to slowly accumulate, progressively "rusting and calcif
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SOURCE Resveratrol Partners LLC
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