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Resveratrol: Thousands of Bottles of Wine, High-Dose Pills Not Required; Mega-doses May Induce Side Effects
Date:6/3/2008

doses of resveratrol (more than 500 mg) began to be employed, side effects like anemia, Achilles heel tendonitis, anxiety reactions, numbness in the fingers, began to be reported," says Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), a leading brand resveratrol dietary supplement. "This is probably because resveratrol is a copper chelator and excessive chelation will impair the availability of copper which is needed for collagen formation and nerve regeneration," he says. "Resveratrol is relatively safe, but not absolutely safe at any dosage. There are drawbacks," he adds.

Some online suppliers of resveratrol pills, who have no medical training, irresponsibly recommend up to 7000 milligrams of resveratrol a day. There is also evidence that supra-high dose resveratrol inhibits the absorption of folic acid (vitamin B9), an essential nutrient needed for DNA repair. [European Journal Nutrition 46: 329-36, 2007] High doses have not been tested in humans for long-term use.

Advertising claims by resveratrol supplement makers that their pills exert greater stimulation of the Sirtuin 1 DNA-repair gene should also be regarded with caution since an animal study shows over-stimulation (greater than 7.5 fold) of this gene induces heart failure in animals. [Circulation Research 2007; 100: 1512-21]

Not just resveratrol

The health and longevity benefits of red wine are not easily explained by the low dose of resveratrol provided in a glass of wine, but are more easily explained by the total milligrams of polyphenolic molecules (resveratrol, quercetin, catechin, kaempferol, ferulic acid), about 60 milligrams per glass of aged red wine, says Sardi. The healthy range for red wine drinking is 3 to 5 glasses, or about 180 to 300 milligrams of polyphenols. Dietary supplements should provide about the same dosage range. Mega-doses are not required and may be problematic.

Red wine is a fermented concentrate of grape skin which provides an arr
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SOURCE Resveratrol Partners LLC
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