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Resveratrol: Thousands of Bottles of Wine, High-Dose Pills Not Required; Mega-doses May Induce Side Effects
Date:6/3/2008

Dynamic Dosing Of Resveratrol Recommended For Optimal Health

SAN DIMAS, Calif., June 3 /PRNewswire/ -- While an earlier published rodent study showed that ultra-high doses of resveratrol (1565 milligram human dose), equivalent to 1500 bottles of wine or many dietary supplement capsules, successfully overcame the adverse effects of a high-fat diet, the lowest dose that genetically mimics a calorie restricted diet went undetermined, till now.

(Photo: http://www.newscom.com/cgi-bin/prnh/20080603/LATU039)

(Photo: http://www.newscom.com/cgi-bin/prnh/20080422/LATU004)

Now an authoritative gene array study, conducted by researchers at the William S. Middleton Memorial Veterans Hospital and Lifegen Technologies in Madison, Wisconsin, shows that a dose of resveratrol (rez-vair-aw-trawl) ~343 milligrams per day (4.9 mg per kilogram of body weight) produces a gene activation profile similar to a calorie restricted diet. Supra-high doses (greater than 500 milligrams) are not required and may produce side effects. [PLOS1, June 2008 available online http://www.plosone.org/home.action ]

Both calorie restriction and resveratrol have been shown to prolong the life of all life forms, ranging from single-cell organisms (yeast cells) to more complex forms of life (fruit flies, roundworms) and warm-blooded mammals (laboratory rats).

Consumers never heard that a far lower human equivalent dose than 1565 milligrams (~360 milligrams) was employed with undisclosed success in a landmark rodent study published in 2006. The lower-dose data were never published. [Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 Nov 16; 444: 337-42]

Drawbacks of supra-high doses

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SOURCE Resveratrol Partners LLC
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