Navigation Links
Resurrection of 3-billion-year-old antibiotic-resistance proteins
Date:2/27/2013

Scientists are reporting "laboratory resurrections" of several 2-3-billion-year-old proteins that are ancient ancestors of the enzymes that enable today's antibiotic-resistant bacteria to shrug off huge doses of penicillins, cephalosporins and other modern drugs. The achievement, reported in the Journal of the American Chemical Society, opens the door to a scientific "replay" of the evolution of antibiotic resistance with an eye to finding new ways to cope with the problem.

Jose M. Sanchez-Ruiz, Eric A. Gaucher, Valeria A. Risso and colleagues explain that antibiotic resistance existed long before Alexander Fleming discovered the first antibiotic in 1928. Genes that contain instructions for making the proteins responsible for antibiotic resistance have been found in 30,000-year-old permafrost sediment and other ancient sites. Their research focused on the so-called beta-lactamases, enzymes responsible for resistance to the family of antibiotics that includes penicillin, which scientists believe originated billions of years ago.

They describe using laboratory and statistical techniques to reconstruct the sequences of beta-lactamase proteins dating to Precambrian times, 2-3 billion years ago. The team also synthesized the inferred ancestral enzymes and conducted studies on their stability, structure and function. "The availability of laboratory resurrections of Precambrian beta-lactamases opens up new possibilities in the study of the emergence of antibiotic resistance," the report states. "For instance, it should now be possible to perform laboratory replays of the molecular tape of lactamase evolution and use such replays to probe the molecular determinants of the efficiency of lactamases to adapt to different types of antibiotics." The authors also note that the extreme stability and catalytic features displayed by the 2-3-billion-year-old lactamases suggest that resurrected Precambrian proteins have utility for the biotechnology industry.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related medicine news :

1. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
2. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
3. Pair of proteins gets brain cells into shape
4. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
5. G proteins regulate remodelling of blood vessels
6. Salk study finds diabetes raises levels of proteins linked to Alzheimers features
7. Toward medicines that recruit the bodys natural disease-fighting proteins
8. Enzymes implicated in disease processes attack one another instead of harming body proteins
9. New regulatory mechanism discovered in cell system for eliminating unneeded proteins
10. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
11. Regulation by proteins outside cancer cells points to potential new drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... April 21, 2017 , ... ... finds that youth violence is declining—and at noteworthy rates. Between 2002 and 2014, ... young people involved in violence in the United States. The study, Trends ...
(Date:4/21/2017)... ... 21, 2017 , ... Young Asset Protection, an insurance provider ... the greater Pittsburgh metropolitan region, is joining forces with the local chapter of ... children. , Variety the Children’s Charity is a national organization dedicated to empowering, ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... it’s been named Agency of Record (AOR) for Theravent, Inc. , the ... snoring. Theravent’s parent company, Foundation Consumer Healthcare, is now working to expand distribution ...
(Date:4/21/2017)... ... ... Alive for Wellness is a group of clinical professionals and ... Alive team uses advanced behavioral sciences treatment modalities to accomplish their goals. ... struggle is based on 10 modalities of treatment that include: , ...
(Date:4/21/2017)... , ... April 21, 2017 ... ... promoting quality-based imaging practices, is seeking candidates to serve on its Accreditation ... imaging. , “RadSite’s ultimate mission is improving image quality and reducing ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017 Research ... of the United States Molecular Imaging Equipment and Radiopharmaceuticals Market, ... ... in molecular imaging equipment revenues as well as growth in ... This will provide value to market participants that design and ...
(Date:4/18/2017)... , April 18, 2017 Recursion Pharmaceuticals ... science with machine learning techniques to discover treatments for ... Yolanda Chong as vice president of biology. ... & Johnson in Belgium , where ... focused on applying high-dimensional biological approaches to the small ...
(Date:4/18/2017)... , April 18, 2017 Research and ... Market 2017-2021" report to their offering. ... The global antiviral drugs market to grow at a ... report, Global Antiviral Drugs Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
Breaking Medicine Technology: