Navigation Links
Results of the TRIGGER-PCI trial reported at TCT 2011
Date:11/9/2011

SAN FRANCISCO, CA NOVEMBER 9, 2011 A clinical trial comparing prasugrel to clopidogrel for patients with high on-clopidogrel platelet reactivity (HCPR) following percutaneous coronary intervention (PCI) was ended early due to relatively few occurrences of cardiac death or myocardial infarction the primary endpoint at six month follow up.

Results of the TRIGGER-PCI (Testing platelet Reactivity In patients underGoing elective stent placement on clopidogrel to Guide alternative thErapy with pRasugrel) trial were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

The risk of ischemic events after percutaneous coronary intervention (PCI) is elevated in patients with high on-clopidogrel platelet reactivity (HCPR). Novel P2Y12-receptor antagonists, such as prasugrel, are more potent than clopidogrel and may, thus, improve outcome with respect to ischemic events, but may also increase bleeding risk.

The trial was a multi-center, double-blind, randomized controlled trial. Platelet reactivity was assessed two to seven hours after the first maintenance dose of clopidogrel 75 mg on the day after PCI following loading with clopidogrel 600 mg and randomized to either prasugrel or clopidogrel. TRIGGER-PCI aimed to randomize 2,150 patients to have a 93% power for detecting a 50% relative risk reduction on prasugrel in the primary study endpoint (cardiovascular death or myocardial infarction within six months).

The study was terminated prematurely for futility at March 18, 2011 at which 236 patients completed the six-month follow up. Only one clinical endpoint, a peri-procedural myocardial infarction, was observed.

"High on-clopidogrel platelet reactivity (>208 PRU by VerifyNow P2Y12 test) was observed less frequently than expected," said Dietmar Trenk PhD. Dr. Trenk is Professor and Head of Clinical Pharmacology at Herz-
'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2009 Financial Results
2. SXC Health Solutions to Host Fiscal 2009 Fourth Quarter and Year End Results Conference Call
3. Team Health Holdings, Inc., Announces Fourth Quarter and Fiscal 2009 Financial Results
4. First blinded study of venous insufficiency prevalence in MS shows promising results
5. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
6. BioMed Realty Trust Reports Fourth Quarter and Full-Year 2009 Financial Results
7. Kaiser Foundation Health Plan and Hospitals Report Fourth Quarter and Fiscal Year 2009 Financial Results
8. United American Healthcare Corporation Announces Fiscal 2010 Second Quarter Results
9. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
10. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
11. WebMD Announces Fourth Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... York, New York (PRWEB) August 23, 2014 ... http://www.consumerinjurylawyers.com/wright-conserve-hip-replacement.html ) filed on behalf of individuals ... the Conserve hip replacement line continue to move ... of Georgia, Bernstein Liebhard LLP reports. According to ... established a bellwether trial program that would allow ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 GBI Research, ... research: “Critical Care Therapeutics in Major Developed Markets to ... Products to Drive Market”, which provides in-depth analysis of ... Germany, Italy, Spain, Japan and Canada. The report provides ... market forecasts to 2020. It covers critical care indications ...
(Date:8/23/2014)... 23, 2014 Pixel Film Studios, a leader ... the release of ProIntro Vol.3, a customizable title tool ... professional tile just by dragging ProIntro Vol.3 in their timeline" ... is a definite time saver and i think our users ... 30 beautifully designed titles made with Final Cut Pro X ...
(Date:8/23/2014)... Youth substance abuse is a serious problem across ... TX. Substance abuse can happen to people of all ... dependency in higher numbers than ever before. Many ... don’t know where to find professional youth rehab. ... because most treatment options are designed for adults. The ...
(Date:8/23/2014)... 23, 2014 Summer vacation is almost over ... back in session. While shopping for school supplies and a ... Batzner encourages parents and students to also spend some time ... are excellent hitchhikers and thrive in heavily populated places,” said ... classrooms and dorms the perfect settings for bed bugs to ...
Breaking Medicine News(10 mins):Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 2Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 3Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:Expert Advice for a Bed Bug-Free School Year 2
... Wound ... ... Medical Technologies , Inc. today announced that its new HemCon Nasal Plugs and Seal-On devices ... The nasal care products will be available from HemCon directly to consumers under ...
... to keep beach underfoot than to dig in it, survey ... the dangers that lurk in sand castles, researchers warn. , ... of North Carolina at Chapel Hill have found that beachgoers ... at higher risk of developing diarrhea and gastrointestinal diseases than ...
... mathematics to take the guesswork out of efforts to ensure ... body parts will have enough blood and oxygen to survive ... model of tissue transfer, mathematicians have shown that they can ... transfer from one part of the body to another location ...
... MONTCLAIR, N.J., July 14 Parentgiving.com, the only comprehensive online resource ... aging parents, announces the launch of the first annual Parentgivers ... honor six selfless caregivers who care for an aging adult while ... July 13 via the Parentgiving website ( www.Parentgiving.com ) ...
... , TOLOCHENAZ, Switzerland, July 14 ... Approval for Medtronic,s Reclaim(R) DBS Therapy for Treatment,of Chronic, ... today announced that Reclaim(R) Deep Brain Stimulation (DBS),Therapy has ... chronic, severe treatment-resistant obsessive-compulsive,disorder (OCD).* This is the first ...
... Users, Guide, a comprehensive resource for endovascular and ... both book and CD formats. This unique reference ... Radiology, a national organization of physicians, scientists and ... through disease management and minimally invasive, image-guided therapeutic ...
Cached Medicine News:Health News:New HemCon/Seal-On Nasal Plugs Control Nosebleeds Quickly, Effectively and Comfortably 2Health News:New HemCon/Seal-On Nasal Plugs Control Nosebleeds Quickly, Effectively and Comfortably 3Health News:Germs Hold Court in Sand Castles 2Health News:Mathematics taking guesswork out of plastic surgery tissue transfer 2Health News:Mathematics taking guesswork out of plastic surgery tissue transfer 3Health News:Mathematics taking guesswork out of plastic surgery tissue transfer 4Health News:Nominate the Parentgivers of the Year 2Health News:World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe 2Health News:World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe 3Health News:World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe 4Health News:New: Interventional radiology coding users' guide 2
(Date:8/22/2014)... On Aug. 20, at its annual meeting in ... voted on and approved a delegate resolution opposing the ... Cannabis Corp., a leading Canadian licensed producer of medicinal ... The CMA is quite right to point out that ... material, including medicinal cannabis. While some patients, particularly those ...
(Date:8/22/2014)... Equity Research highlights Epizyme (Nasdaq: EPZM - Free Report ... PNRA - Free Report ) as the Bear of the Day. ... FOLD - Free Report ), Sanofi (NYSE: SNY - ... ). Here is a synopsis of all five stocks: ... The biotech bull market is far from over due to ...
(Date:8/22/2014)... , Aug. 22, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, is pleased ... international medical cannabis conference taking place at the ... , on October 22, 2014.  The multilingual ... such as researchers, health professionals, and patients, to ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... ARBOR, Mich., Nov. 9 Thomson Reuters ... a leading clinical surveillance solution that enables hospitals to ... improve clinical quality and reduce total cost of treatment. ... at no additional cost. , CareFocus 2.0 ...
... Nov. 9 Arcadia Resources, Inc. (NYSE Amex: ... care services under the Arcadia HealthCare(SM) brand, has appointed ... will replace Tres Lund who announced his resignation from ... http://www.newscom.com/cgi-bin/prnh/20091109/DE07521 ) , Goldsmith is the Daniel ...
Cached Medicine Technology:Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 2Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 3Arcadia Resources Names Stephen Goldsmith to Board of Directors 2Arcadia Resources Names Stephen Goldsmith to Board of Directors 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: